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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1987 Aug;41(2):168–179.

Huntington disease in Maryland: clinical aspects of racial variation.

S E Folstein, G A Chase, W E Wahl, A M McDonnell, M F Folstein
PMCID: PMC1684204  PMID: 2956881

Abstract

In a Maryland survey of Huntington disease, the prevalence in blacks was unexpectedly high and equal to that in whites. Age at onset was earlier in blacks, and their clinical features, at all ages at onset, were similar to those seen in juvenile-onset Huntington disease. Blacks had more severe bradykinesia and abnormalities of eye movement and less frequent psychiatric disorder, particularly depression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bird E. D., Caro A. J., Pilling J. B. A sex related factor in the inheritance of Huntington's chorea. Ann Hum Genet. 1974 Jan;37(3):255–260. doi: 10.1111/j.1469-1809.1974.tb01833.x. [DOI] [PubMed] [Google Scholar]
  2. Farrer L. A., Conneally P. M. A genetic model for age at onset in Huntington disease. Am J Hum Genet. 1985 Mar;37(2):350–357. [PMC free article] [PubMed] [Google Scholar]
  3. Folstein S. E., Abbott M. H., Franz M. L., Huang S., Chase G. A., Folstein M. F. Phenotypic heterogeneity in Huntington disease. J Neurogenet. 1984 Apr;1(2):175–184. doi: 10.3109/01677068409107083. [DOI] [PubMed] [Google Scholar]
  4. Folstein S. E., Folstein M. F. Psychiatric features of Huntington's disease: recent approaches and findings. Psychiatr Dev. 1983 Summer;1(2):193–205. [PubMed] [Google Scholar]
  5. Folstein S. E., Jensen B., Leigh R. J., Folstein M. F. The measurement of abnormal movement: methods developed for Huntington's disease. Neurobehav Toxicol Teratol. 1983 Nov-Dec;5(6):605–609. [PubMed] [Google Scholar]
  6. Folstein S. E., Leigh R. J., Parhad I. M., Folstein M. F. The diagnosis of Huntington's disease. Neurology. 1986 Oct;36(10):1279–1283. doi: 10.1212/wnl.36.10.1279. [DOI] [PubMed] [Google Scholar]
  7. Folstein S. E., Phillips J. A., 3rd, Meyers D. A., Chase G. A., Abbott M. H., Franz M. L., Waber P. G., Kazazian H. H., Jr, Conneally P. M., Hobbs W. Huntington's disease: two families with differing clinical features show linkage to the G8 probe. Science. 1985 Aug 23;229(4715):776–779. doi: 10.1126/science.2992086. [DOI] [PubMed] [Google Scholar]
  8. Folstein S., Abbott M. H., Chase G. A., Jensen B. A., Folstein M. F. The association of affective disorder with Huntington's disease in a case series and in families. Psychol Med. 1983 Aug;13(3):537–542. doi: 10.1017/s0033291700047966. [DOI] [PubMed] [Google Scholar]
  9. Glass J., Saffer D. S. Huntington's chorea in a black family: a report of 2 cases. S Afr Med J. 1979 Oct 20;56(17):685–688. [PubMed] [Google Scholar]
  10. Gusella J. F., Wexler N. S., Conneally P. M., Naylor S. L., Anderson M. A., Tanzi R. E., Watkins P. C., Ottina K., Wallace M. R., Sakaguchi A. Y. A polymorphic DNA marker genetically linked to Huntington's disease. Nature. 1983 Nov 17;306(5940):234–238. doi: 10.1038/306234a0. [DOI] [PubMed] [Google Scholar]
  11. HUTTON P. W. Neurological disease in Uganda. East Afr Med J. 1956 Jun;33(6):209–223. [PubMed] [Google Scholar]
  12. Hayden M. R., Beighton P. Huntington's chorea in the Cape coloured community of South Africa. S Afr Med J. 1977 Nov 19;52(22):886–888. [PubMed] [Google Scholar]
  13. Hayden M. R., MacGregor J. M., Saffer D. S., Beighton P. H. The high frequency of juvenile Huntington's chorea in South Africa. J Med Genet. 1982 Apr;19(2):94–97. doi: 10.1136/jmg.19.2.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Heathfield K. W. Huntington's chorea. Investigation into the prevalence of this disease in the area covered by the North East Metropolitan Regional Hospital Board. Brain. 1967 Mar;90(1):203–232. doi: 10.1093/brain/90.1.203. [DOI] [PubMed] [Google Scholar]
  15. Jones M. B., Phillips C. R. Affected parent and age of onset in Huntington's chorea. J Med Genet. 1970 Mar;7(1):20–21. doi: 10.1136/jmg.7.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. KLINTWORTH G. K. Huntington's chorea in South Africa. A preliminary communication drawing attention to its frequent occurrence. S Afr Med J. 1962 Oct 27;36:896–898. [PubMed] [Google Scholar]
  17. Leigh R. J., Newman S. A., Folstein S. E., Lasker A. G., Jensen B. A. Abnormal ocular motor control in Huntington's disease. Neurology. 1983 Oct;33(10):1268–1275. doi: 10.1212/wnl.33.10.1268. [DOI] [PubMed] [Google Scholar]
  18. Newcombe R. G., Walker D. A., Harper P. S. Factors influencing age at onset and duration of survival in Huntington's chorea. Ann Hum Genet. 1981 Oct;45(Pt 4):387–396. doi: 10.1111/j.1469-1809.1981.tb00352.x. [DOI] [PubMed] [Google Scholar]
  19. REED T. E., CHANDLER J. H. Huntington's chorea in Michigan. I. Demography and genetics. Am J Hum Genet. 1958 Jun;10(2):201–225. [PMC free article] [PubMed] [Google Scholar]
  20. Robins L. N., Helzer J. E., Weissman M. M., Orvaschel H., Gruenberg E., Burke J. D., Jr, Regier D. A. Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry. 1984 Oct;41(10):949–958. doi: 10.1001/archpsyc.1984.01790210031005. [DOI] [PubMed] [Google Scholar]
  21. Saffer D. S., Nathan D. C., Kahle P. A., Steingo B. Huntington's disease in a Coloured family. S Afr Med J. 1974 Nov 30;48(58):2399–2402. [PubMed] [Google Scholar]
  22. Samuels B. L., Gelfand M. Huntington's chorea in a black Rhodesian family. S Afr Med J. 1978 Oct 14;54(16):648–651. [PubMed] [Google Scholar]
  23. Still C. N. Huntington's chorea in South Carolina: natural history and clinical features. Neurol Neurocir Psiquiatr. 1977;18(2-3):193–198. [PubMed] [Google Scholar]
  24. Wallace D. C., Hall A. C. Evidence of genetic heterogeneity in Huntington's chorea. J Neurol Neurosurg Psychiatry. 1972 Dec;35(6):789–800. doi: 10.1136/jnnp.35.6.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wallace D. C. Huntington's chorea in Queensland. A not uncommon disease. Med J Aust. 1972 Feb 12;1(7):299–307. [PubMed] [Google Scholar]
  26. Went L. N., Vegter-van der Vlis M., Bruyn G. W., Volkers W. S. Huntington's Chorea in the Netherlands. The problem of genetic heterogeneity. Ann Hum Genet. 1983 Jul;47(Pt 3):205–214. doi: 10.1111/j.1469-1809.1983.tb00989.x. [DOI] [PubMed] [Google Scholar]
  27. Wright H. H., Still C. N., Abramson R. K. Huntington's disease in black kindreds in South Carolina. Arch Neurol. 1981 Jul;38(7):412–414. doi: 10.1001/archneur.1981.00510070046005. [DOI] [PubMed] [Google Scholar]

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