Abstract
Huntington disease, one of the longest established and most serious human genetic disorders, has been the subject of considerable abuse during the present century in relation to the application of genetic knowledge, most notably in Nazi Germany but also in other countries. This disorder provides a valuable example of how abuses in the past need to be recognized and confronted, if we are to avoid their recurrence in relation to new molecular and computing techniques in genetics.
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Selected References
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- Brandt J., Quaid K. A., Folstein S. E., Garber P., Maestri N. E., Abbott M. H., Slavney P. R., Franz M. L., Kasch L., Kazazian H. H., Jr Presymptomatic diagnosis of delayed-onset disease with linked DNA markers. The experience in Huntington's disease. JAMA. 1989 Jun 2;261(21):3108–3114. [PubMed] [Google Scholar]
- Conneally P. M., Haines J. L., Tanzi R. E., Wexler N. S., Penchaszadeh G. K., Harper P. S., Folstein S. E., Cassiman J. J., Myers R. H., Young A. B. Huntington disease: no evidence for locus heterogeneity. Genomics. 1989 Aug;5(2):304–308. doi: 10.1016/0888-7543(89)90062-1. [DOI] [PubMed] [Google Scholar]
- Meyer J. E. The fate of the mentally ill in Germany during the Third Reich. Psychol Med. 1988 Aug;18(3):575–581. doi: 10.1017/s0033291700008254. [DOI] [PubMed] [Google Scholar]
- Morris M. J., Tyler A., Lazarou L., Meredith L., Harper P. S. Problems in genetic prediction for Huntington's disease. Lancet. 1989 Sep 9;2(8663):601–603. doi: 10.1016/s0140-6736(89)90721-6. [DOI] [PubMed] [Google Scholar]
- Morris M., Tyler A., Harper P. S. Adoption and genetic prediction for Huntington's disease. Lancet. 1988 Nov 5;2(8619):1069–1070. doi: 10.1016/s0140-6736(88)90078-5. [DOI] [PubMed] [Google Scholar]
- Nolan K. Human immunodeficiency virus infection, women, and pregnancy. Ethical issues. Obstet Gynecol Clin North Am. 1990 Sep;17(3):651–668. [PubMed] [Google Scholar]