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. 1987 Nov;41(5):742–760.

A controlled study of Tourette syndrome. II. Conduct.

D E Comings 1, B G Comings 1
PMCID: PMC1684337  PMID: 3479013

Abstract

To assess conduct in Tourette syndrome (TS), 47 controls, 246 TS patients, 17 attention-deficit-disorder (ADD), and 15 ADD patients with minor tics or a family history of TS (ADD 2(0) TS) were compared for the following behaviors: running away from home, lying, stealing, starting fires, vandalism, being in trouble with the law, fighting, shouting at parents or peers, attacking others, lack of respect for adults, short temper, hurting animals, feeling full of hate, being unable to stop fighting, and problems with drugs and alcohol. With the exception of running away from home and being in trouble with the law, TS patients were significantly different from controls in all other behaviors. When the components were combined for a total conduct score, only one (2.1%) of the controls had a score greater than 13, and he had TS. By contrast, 35% of the TS patients had scores greater than 13 (P less than .0005). The correlation coefficient between the total conduct score and ADD score was .48. Although the presence of ADD was an important factor in determining conduct in TS, other factors such as depression and compulsive behavior also played a contributing role. There was little correlation between the total conduct score and the number of tics. It is estimated that among non-economically disadvantaged children, 10%-30% of conduct disorder may be due to the presence of a TS gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abou-Saleh M. T., Coppen A. The prognosis of depression in old age: the case for lithium therapy. Br J Psychiatry. 1983 Nov;143:527–528. doi: 10.1192/bjp.143.5.527. [DOI] [PubMed] [Google Scholar]
  2. Comings D. E., Comings B. G., Devor E. J., Cloninger C. R. Detection of major gene for Gilles de la Tourette syndrome. Am J Hum Genet. 1984 May;36(3):586–600. [PMC free article] [PubMed] [Google Scholar]
  3. Comings D. E., Comings B. G. Tourette's syndrome and attention deficit disorder with hyperactivity: are they genetically related? J Am Acad Child Psychiatry. 1984 Mar;23(2):138–146. doi: 10.1097/00004583-198403000-00004. [DOI] [PubMed] [Google Scholar]
  4. Gittelman R., Mannuzza S., Shenker R., Bonagura N. Hyperactive boys almost grown up. I. Psychiatric status. Arch Gen Psychiatry. 1985 Oct;42(10):937–947. doi: 10.1001/archpsyc.1985.01790330017002. [DOI] [PubMed] [Google Scholar]
  5. McMahon T. Bipolar affective symptoms associated with use of captopril and abrupt withdrawal of pargyline and propranolol. Am J Psychiatry. 1985 Jun;142(6):759–760. doi: 10.1176/ajp.142.6.759. [DOI] [PubMed] [Google Scholar]
  6. Moldofsky H., Tullis C., Lamon R. Multiple tic syndrome (Giles de la Tourette's syndrome). J Nerv Ment Dis. 1974 Oct;159(4):282–292. doi: 10.1097/00005053-197410000-00007. [DOI] [PubMed] [Google Scholar]
  7. Pauls D. L., Leckman J. F. The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission. N Engl J Med. 1986 Oct 16;315(16):993–997. doi: 10.1056/NEJM198610163151604. [DOI] [PubMed] [Google Scholar]
  8. Prinz R. J., Connor P. A., Wilson C. C. Hyperactive and aggressive behaviors in childhood: intertwined dimensions. J Abnorm Child Psychol. 1981 Jun;9(2):191–202. doi: 10.1007/BF00919114. [DOI] [PubMed] [Google Scholar]
  9. Shapiro A. K., Shapiro E. Subcategorizing Gilles de la Tourett's syndrome. Am J Psychiatry. 1977 Jul;134(7):818–819. doi: 10.1176/ajp.134.7.aj1347818. [DOI] [PubMed] [Google Scholar]
  10. Stefl M. E. Mental health needs associated with Tourette syndrome. Am J Public Health. 1984 Dec;74(12):1310–1313. doi: 10.2105/ajph.74.12.1310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Stewart M. A., Cummings C., Singer S., deBlois C. S. The overlap between hyperactive and unsocialized aggressive children. J Child Psychol Psychiatry. 1981 Jan;22(1):35–45. doi: 10.1111/j.1469-7610.1981.tb00529.x. [DOI] [PubMed] [Google Scholar]
  12. Twito T. J., Stewart M. A. A half-sibling study of aggressive conduct disorder. Prevalence of disorders in parents, brothers and sisters. Neuropsychobiology. 1982;8(3):144–150. doi: 10.1159/000117890. [DOI] [PubMed] [Google Scholar]
  13. Wilson R. S., Garron D. C., Tanner C. M., Klawans H. L. Behavior disturbance in children with Tourette syndrome. Adv Neurol. 1982;35:329–333. [PubMed] [Google Scholar]

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