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. 1984 Mar;36(2):329–337.

c-Ha-ras-1 oncogene lies between beta-globin and insulin loci on human chromosome 11p.

E R Fearon, S E Antonarakis, D A Meyers, M A Levine
PMCID: PMC1684411  PMID: 6324580

Abstract

DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey ras 1 oncogene (c-Ha-ras-1), beta-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the beta-globin locus (theta = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (theta = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-beta globin-c-Ha-ras-1-insulin.

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Selected References

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