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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1984 May;36(3):704–709.

Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission.

E J Devor
PMCID: PMC1684450  PMID: 6587775

Abstract

A sample of 35 published pedigrees of Gilles de la Tourette syndrome is studied using complex segregation analysis with pointers. Results indicate the presence of a rare, semidominant, incompletely penetrant allele leading to affection. This result is consistent with that previously reported by Comings et al. on a larger, independent sample.

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Selected References

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  1. CHAPEL J. L., BROWN N., JENKINS R. L. TOURETTE'S DISEASE: SYMPTOMATIC RELIEF WITH HALOPERIDOL. Am J Psychiatry. 1964 Dec;121:608–610. doi: 10.1176/ajp.121.6.608. [DOI] [PubMed] [Google Scholar]
  2. Comings D. E., Comings B. G., Devor E. J., Cloninger C. R. Detection of major gene for Gilles de la Tourette syndrome. Am J Hum Genet. 1984 May;36(3):586–600. [PMC free article] [PubMed] [Google Scholar]
  3. Eldridge R., Sweet R., Lake R., Ziegler M., Shapiro A. K. Gilles de la Tourette's syndrome: clinical, genetic, psychologic, and biochemical aspects in 21 selected families. Neurology. 1977 Feb;27(2):115–124. doi: 10.1212/wnl.27.2.115. [DOI] [PubMed] [Google Scholar]
  4. Heston L. L., Mastri A. R., Anderson V. E., White J. Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions. Arch Gen Psychiatry. 1981 Oct;38(10):1085–1090. doi: 10.1001/archpsyc.1981.01780350019001. [DOI] [PubMed] [Google Scholar]
  5. Kidd K. K., Prusoff B. A., Cohen D. J. Familial pattern of Gilles de la Tourette syndrome. Arch Gen Psychiatry. 1980 Dec;37(12):1336–1339. doi: 10.1001/archpsyc.1980.01780250022001. [DOI] [PubMed] [Google Scholar]
  6. Lalouel J. M., Morton N. E. Complex segregation analysis with pointers. Hum Hered. 1981;31(5):312–321. doi: 10.1159/000153231. [DOI] [PubMed] [Google Scholar]
  7. Lalouel J. M., Morton N. E., MacLean C. J., Jackson J. Recurrence risks in complex inheritance with special regard to pyloric stenosis. J Med Genet. 1977 Dec;14(6):408–414. doi: 10.1136/jmg.14.6.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lalouel J. M., Rao D. C., Morton N. E., Elston R. C. A unified model for complex segregation analysis. Am J Hum Genet. 1983 Sep;35(5):816–826. [PMC free article] [PubMed] [Google Scholar]
  9. Moldofsky H., Tullis C., Lamon R. Multiple tic syndrome (Giles de la Tourette's syndrome). J Nerv Ment Dis. 1974 Oct;159(4):282–292. doi: 10.1097/00005053-197410000-00007. [DOI] [PubMed] [Google Scholar]
  10. Morton N. E. Analysis of family resemblance. I. Introduction. Am J Hum Genet. 1974 May;26(3):318–330. [PMC free article] [PubMed] [Google Scholar]
  11. Morton N. E., MacLean C. J. Analysis of family resemblance. 3. Complex segregation of quantitative traits. Am J Hum Genet. 1974 Jul;26(4):489–503. [PMC free article] [PubMed] [Google Scholar]
  12. Nee L. E., Caine E. D., Polinsky R. J., Eldridge R., Ebert M. H. Gilles de la Tourette syndrome: clinical and family study of 50 cases. Ann Neurol. 1980 Jan;7(1):41–49. doi: 10.1002/ana.410070109. [DOI] [PubMed] [Google Scholar]
  13. Wassman E. R., Eldridge R., Abuzzahab S., Sr, Nee L. Gilles de la Tourette syndrome: clinical and genetic studies in a midwestern city. Neurology. 1978 Mar;28(3):304–307. doi: 10.1212/wnl.28.3.304. [DOI] [PubMed] [Google Scholar]

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