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. 1984 Jul;36(4):760–768.

The genes coding for A alpha-, B beta-, and gamma-chains of fibrinogen map to 4q2.

I Henry, G Uzan, D Weil, H Nicolas, J C Kaplan, C Marguerie, A Kahn, C Junien
PMCID: PMC1684488  PMID: 6089549

Abstract

We used cloned cDNA probes for the A alpha-, B beta-, and gamma-chains of human fibrinogen and Southern blotting techniques to analyze DNA from a series of rodent X human somatic cell hybrids for the presence of specific fibrinogen-related sequences. Our results provide evidence for the assignment of the three genes for fibrinogen to chromosome 4. Moreover, by direct gene-dosage determination in two patients with chromosome 4 unbalanced rearrangements, we refined the regional chromosomal assignment to 4q2, thus suggesting that these three genes whose expression is coordinately regulated are closely linked.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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