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. 1985 Jan;37(1):199–207.

Genes controlling gp25/30 cell-surface molecules map to chromosomes X and Y and escape X-inactivation.

N C Dracopoli, W J Rettig, A P Albino, D Esposito, N Archidiacono, M Rocchi, M Siniscalco, L J Old
PMCID: PMC1684553  PMID: 4038849

Abstract

The monoclonal antibody AbO13 defines a cell-surface antigen that is expressed on most cultured human cells, but not on rodent cells. AbO13 precipitates glycoproteins of 25,000 and 30,000 mol. wt. from lysates of [3H]glucosamine-labeled human cells. Results of the serological typing of a panel of 25 rodent-human somatic cell hybrid clones show that reactivity with AbO13 segregates with the human X and Y chromosomes. The presence of either of these chromosomes is sufficient for O13 expression on the hybrid cell surface. Analysis of hybrid clones containing human X chromosomes with karyotypically defined deletions permitted the regional assignment of the X-linked gene locus controlling the expression of O13 to Xp22-pter. In addition, AbO13 is reactive with Chinese hamster-human hybrids derived from fibroblasts of a 49,XXXXX individual that contained only inactivated copies of the human X chromosome. These results suggest that the X-linked locus determining the expression of O13 is not subject to X-inactivation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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