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. 1986 Jun;38(6):819–826.

Localization of the gene encoding human erythroid-potentiating activity to chromosome region Xp11.1----Xp11.4.

K Huebner, M Isobe, J C Gasson, D W Golde, C M Croce
PMCID: PMC1684855  PMID: 3460333

Abstract

We have localized the human gene for erythroid potentiating activity (EPA) to the X chromosome by analysis of its segregation pattern in mouse-human somatic cell hybrids. The EPA gene has been further localized to human chromosome region Xp11.1----Xp11.4 by in situ hybridization of a molecularly cloned EPA genomic fragment to metaphase chromosomes.

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Selected References

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  1. Cannizzaro L. A., Emanuel B. S. An improved method for G-banding chromosomes after in situ hybridization. Cytogenet Cell Genet. 1984;38(4):308–309. doi: 10.1159/000132079. [DOI] [PubMed] [Google Scholar]
  2. Croce C. M., Isobe M., Palumbo A., Puck J., Ming J., Tweardy D., Erikson J., Davis M., Rovera G. Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science. 1985 Mar 1;227(4690):1044–1047. doi: 10.1126/science.3919442. [DOI] [PubMed] [Google Scholar]
  3. Croce C. M., Koprowski H., Litwack G. Regulation of the corticosteroid inducibility of tyrosine aminotransferase in interspecific hybrid cells. Nature. 1974 Jun 28;249(460):839–841. doi: 10.1038/249839a0. [DOI] [PubMed] [Google Scholar]
  4. Dalla-Favera R., Bregni M., Erikson J., Patterson D., Gallo R. C., Croce C. M. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7824–7827. doi: 10.1073/pnas.79.24.7824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Danks D. M., Cartwright E., Campbell P. E., Mayne V. Is Menkes' syndrome a heritable disorder of connective tissue? Lancet. 1971 Nov 13;2(7733):1089–1089. doi: 10.1016/s0140-6736(71)90403-x. [DOI] [PubMed] [Google Scholar]
  6. Docherty A. J., Lyons A., Smith B. J., Wright E. M., Stephens P. E., Harris T. J., Murphy G., Reynolds J. J. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature. 1985 Nov 7;318(6041):66–69. doi: 10.1038/318066a0. [DOI] [PubMed] [Google Scholar]
  7. Erikson J., Williams D. L., Finan J., Nowell P. C., Croce C. M. Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias. Science. 1985 Aug 23;229(4715):784–786. doi: 10.1126/science.3875152. [DOI] [PubMed] [Google Scholar]
  8. Gasson J. C., Bersch N., Golde D. W. Characterization of purified human erythroid-potentiating activity. Prog Clin Biol Res. 1985;184:95–104. [PubMed] [Google Scholar]
  9. Gasson J. C., Golde D. W., Kaufman S. E., Westbrook C. A., Hewick R. M., Kaufman R. J., Wong G. G., Temple P. A., Leary A. C., Brown E. L. Molecular characterization and expression of the gene encoding human erythroid-potentiating activity. 1985 Jun 27-Jul 3Nature. 315(6022):768–771. doi: 10.1038/315768a0. [DOI] [PubMed] [Google Scholar]
  10. Golde D. W., Bersch N., Quan S. G., Lusis A. J. Production of erythroid-potentiating activity by a human T-lymphoblast cell line. Proc Natl Acad Sci U S A. 1980 Jan;77(1):593–596. doi: 10.1073/pnas.77.1.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harper M. E., Saunders G. F. Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization. Chromosoma. 1981;83(3):431–439. doi: 10.1007/BF00327364. [DOI] [PubMed] [Google Scholar]
  12. Huebner K., Palumbo A. P., Isobe M., Kozak C. A., Monaco S., Rovera G., Croce C. M., Curtis P. J. The alpha-spectrin gene is on chromosome 1 in mouse and man. Proc Natl Acad Sci U S A. 1985 Jun;82(11):3790–3793. doi: 10.1073/pnas.82.11.3790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ihle J. N., Keller J., Oroszlan S., Henderson L. E., Copeland T. D., Fitch F., Prystowsky M. B., Goldwasser E., Schrader J. W., Palaszynski E. Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity. J Immunol. 1983 Jul;131(1):282–287. [PubMed] [Google Scholar]
  14. Isobe M., Huebner K., Erikson J., Peterson R. C., Bollum F. J., Chang L. M., Croce C. M. Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5836–5840. doi: 10.1073/pnas.82.17.5836. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lyon M. F., Hawkes S. G. X-linked gene for testicular feminization in the mouse. Nature. 1970 Sep 19;227(5264):1217–1219. doi: 10.1038/2271217a0. [DOI] [PubMed] [Google Scholar]
  16. MENKES J. H., ALTER M., STEIGLEDER G. K., WEAKLEY D. R., SUNG J. H. A sex-linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration. Pediatrics. 1962 May;29:764–779. [PubMed] [Google Scholar]
  17. Migeon B. R., Brown T. R., Axelman J., Migeon C. J. Studies of the locus for androgen receptor: localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6339–6343. doi: 10.1073/pnas.78.10.6339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rigby P. W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977 Jun 15;113(1):237–251. doi: 10.1016/0022-2836(77)90052-3. [DOI] [PubMed] [Google Scholar]
  19. Ropers H. H., Wieacker P., Wienker T. F., Davies K., Williamson R. On the genetic length of the short arm of the human X chromosome. Hum Genet. 1983;65(1):53–55. doi: 10.1007/BF00285028. [DOI] [PubMed] [Google Scholar]
  20. Rowe D. W., McGoodwin E. B., Martin G. R., Sussman M. D., Grahn D., Faris B., Franzblau C. A sex-linked defect in the cross-linking of collagen and elastin associated with the mottled locus in mice. J Exp Med. 1974 Jan 1;139(1):180–192. doi: 10.1084/jem.139.1.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  22. Westbrook C. A., Gasson J. C., Gerber S. E., Selsted M. E., Golde D. W. Purification and characterization of human T-lymphocyte-derived erythroid-potentiating activity. J Biol Chem. 1984 Aug 25;259(16):9992–9996. [PubMed] [Google Scholar]
  23. Wienker T. F., Wieacker P., Cooke H. J., Horn N., Ropers H. H. Evidence that the Menkes locus maps on proximal Xp. Hum Genet. 1983;65(1):72–73. doi: 10.1007/BF00285032. [DOI] [PubMed] [Google Scholar]

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