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. 1976 May;28(3):270–279.

A new look at the protection of hemoglobin AS and AC genotypes against plasmodium falciparum infection: a census tract approach.

B Ringelhann, M K Hathorn, P Jilly, F Grant, G Parniczky
PMCID: PMC1685008  PMID: 773175

Abstract

A total of 4,097 randomly selected children under 5 years in Accra, Ghana were investigated for Hb type, malarial parasite species, and parasite density. Even though malarial infection rates in this metropolitan population were lower as compared to holoendemic areas, the differential survival of Hb S carriers was confirmed. In addition, similar but less pronounced survival effects were seen in Hb C heterozygotes. Hb S carriers had the highest infection rates. More females than males were infected. Individuals with a moderate parasite count (less than 50,000/ml) were seen more commonly amoung AS and AC individuals as compared to AA controls. It is postulated that heterozygotes have a better immunological defense against the deleterious effects of P. falciparum infection because persistent parasitemia stimulates antibody production.

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Selected References

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  1. ALLISON A. C. Genetic factors in resistance to malaria. Ann N Y Acad Sci. 1961 Jun 7;91:710–729. doi: 10.1111/j.1749-6632.1961.tb31102.x. [DOI] [PubMed] [Google Scholar]
  2. ALLISON A. C. Protection afforded by sickle-cell trait against subtertian malareal infection. Br Med J. 1954 Feb 6;1(4857):290–294. doi: 10.1136/bmj.1.4857.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bienzle U., Okoye V. C., Gögler H. Haemoglobin and glucose-6-phosphate dehydrogenase variants: distribution in relation to malaria endemicity in a Togolese population. Z Tropenmed Parasitol. 1972 Mar;23(1):56–62. [PubMed] [Google Scholar]
  4. Boyo A. E. Malariometric indices and hemoglobin type. Am J Trop Med Hyg. 1972 Nov;21(6):863–867. doi: 10.4269/ajtmh.1972.21.863. [DOI] [PubMed] [Google Scholar]
  5. COLBOURNE M. J., EDINGTON G. M. Mortality from malaria in Accra. J Trop Med Hyg. 1954 Sep;57(9):203–210. [PubMed] [Google Scholar]
  6. EDINGTON G. M., LAING W. N. Relationship between haemoglobins C and S and malaria in Ghana. Br Med J. 1957 Jul 20;2(5037):143–145. doi: 10.1136/bmj.2.5037.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FOY H., BRASS W., MOORE R. A., TIMMS G. L., KONDI A., OLUOCH T. Two surveys to investigate the relation of sickle-cell trait and malaria. Br Med J. 1955 Nov 5;2(4948):1116–1119. doi: 10.1136/bmj.2.4948.1116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gilles H. M., Fletcher K. A., Hendrickse R. G., Lindner R., Reddy S., Allan N. Glucose-6-phosphate-dehydrogenase deficiency, sickling, and malaria in African children in South Western Nigeria. Lancet. 1967 Jan 21;1(7482):138–140. doi: 10.1016/s0140-6736(67)91037-9. [DOI] [PubMed] [Google Scholar]
  9. LAMBOTTE-LEGRAND J., LAMBOTTE-LEGRAND C. Notes complémentaires sur la drépanocytose. I. Sicklémie et malaria. Ann Soc Belg Med Trop (1920) 1958 Feb 28;38(1):45–53. [PubMed] [Google Scholar]
  10. Luzzatto L., Nwachuku-Jarrett E. S., Reddy S. Increased sickling of parasitised erythrocytes as mechanism of resistance against malaria in the sickle-cell trait. Lancet. 1970 Feb 14;1(7642):319–321. doi: 10.1016/s0140-6736(70)90700-2. [DOI] [PubMed] [Google Scholar]
  11. MOORE R. A., BRASS W., FOY H. Sickling and malaria. Br Med J. 1954 Sep 11;2(4888):630–631. doi: 10.1136/bmj.2.4888.630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MOTULSKY A. G. HEREDITARY RED CELL TRAITS AND MALARIA. Am J Trop Med Hyg. 1964 Jan;13:SUPPL147–SUPPL158. doi: 10.4269/ajtmh.1964.13.147. [DOI] [PubMed] [Google Scholar]
  13. McGregor I. A. Immunity and malaria in man. Trop Doct. 1974 Jul;4(3):104–109. doi: 10.1177/004947557400400304. [DOI] [PubMed] [Google Scholar]
  14. Motulsky A. G., Vandepitte J., Fraser G. R. Population genetic studies in the Congo. I. Glucose-6-phosphate dehydrogenase deficiency, hemoglobin S, and malaria. Am J Hum Genet. 1966 Nov;18(6):514–537. [PMC free article] [PubMed] [Google Scholar]
  15. RAPER A. B. Malaria and the sickling trait. Br Med J. 1955 May 14;1(4923):1186–1189. doi: 10.1136/bmj.1.4923.1186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. ROBERTS D. F., BOYO A. E. On the stability of haemoglobin gene frequencies in West Africa. Ann Hum Genet. 1960 Dec;24:375–387. doi: 10.1111/j.1469-1809.1960.tb01750.x. [DOI] [PubMed] [Google Scholar]
  17. STRESS and corticotrophin. Br Med J. 1956 Jul 7;2(4983):33–34. [PMC free article] [PubMed] [Google Scholar]
  18. THOMPSON G. R. MALARIA AND STRESS IN RELATION TO HAEMOGLOBINS S AND C. Br Med J. 1963 Oct 19;2(5363):976–978. doi: 10.1136/bmj.2.5363.976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. THOMPSON G. R. Significance of haemoglobins S and C in Ghana. Br Med J. 1962 Mar 10;1(5279):682–685. doi: 10.1136/bmj.1.5279.682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. VANDEPITTE J., DELAISSE J. Sicklémie et paludisme; aperçu de problème et contribution personnelle. Ann Soc Belg Med Trop (1920) 1957 Oct 31;37(5):703–735. [PubMed] [Google Scholar]
  21. VANDEPITTE J., DHERTE P. [Inquiry on abnormal hemoglobins in Stanleyville]. Ann Soc Belg Med Trop (1920) 1959 Oct 31;39:711–715. [PubMed] [Google Scholar]
  22. WALTERS J. H., LEHMANN H. Distribution of the S and C haemoglobin variants in two Nigerian communities. Trans R Soc Trop Med Hyg. 1956 May;50(3):204–208. doi: 10.1016/0035-9203(56)90024-4. [DOI] [PubMed] [Google Scholar]
  23. WENT L. N. Segregation-ratio advantage of abnormal haemoglobins. Nature. 1961 Oct 28;192:382–383. doi: 10.1038/192382a0. [DOI] [PubMed] [Google Scholar]

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