Skip to main content
NCBI home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1976 May;28(3):262–269.

The frequency of "rare" protein variants in Marshall islanders and other Micronesians.

J V Neel, R E Ferrell, R A Conard
PMCID: PMC1685014  PMID: 1266854

Abstract

Blood specimens from a sample of 373 Marshall Islanders were studied with reference to variants of 23 serum proteins and erythrocyte enzymes. Six of the traits studied exhibited genetic polymorphisms (adenosine deaminase, phosphoglucomutase1, acid phosphatase, 6-phosphogluconate dehydrogenase, haptoglobin, and group specific component). There were in addition four "rare" variants (albumin, transferrin, lactate dehydrogenase, and galactose-1-phosphate uridylyltransferase) involving nine persons, among 8,503 determinations. The frequency of rare variants in Micronesians was compared with the frequencies in West European Caucasians and Amerindians. There are many difficulties in such comparisons, and although the observed values for the three ethnic groups differ by a factor of three (the Micronesians exhibiting the lowest frequency), it is felt that no firm conclusions concerning differences between ethnic groups can be drawn at this time.

Full text

PDF
262

Images in this article

265Fig. 1
on p.265
266Fig. 2
on p.266

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ananthakrishnan R., Blake N. M., Kirk R. L., Baxi A. J. Further studies on the distribution of genetic variants of lactate dehydrogenase in India. Med J Aust. 1970 Oct 24;2(17):787–789. doi: 10.5694/j.1326-5377.1970.tb63171.x. [DOI] [PubMed] [Google Scholar]
  2. Bajatzadeh M., Walter H. Studies on the population genetics of the ceruloplasmin polymorphism. Humangenetik. 1969 Oct;8(2):134–136. doi: 10.1007/BF00295836. [DOI] [PubMed] [Google Scholar]
  3. Blake N. M., Omoto K., Kirk R. L., Gajdusek D. C. Variation in red cell enzyme groups among populations of the Western Caroline Islands, Micronesia. Am J Hum Genet. 1973 Jul;25(4):413–421. [PMC free article] [PubMed] [Google Scholar]
  4. Chen S. H., Anderson J. E., Giblett E. R. 2,3-diphosphoglycerate mutase: Its demonstration by electrophoresis and the detection of a genetic variant. Biochem Genet. 1971 Oct;5(5):481–486. doi: 10.1007/BF00487137. [DOI] [PubMed] [Google Scholar]
  5. DOUGLAS R., JACOBS J., SHERLIKER J., STAVELEY J. M. Blood groups, serum genetic factors, and haemoglobins in Gilbert Islanders. N Z Med J. 1961 Apr;60:146–152. [PubMed] [Google Scholar]
  6. Edwards Y. H., Hopkinson D. A., Harris H. Inherited variants of human nucleoside phosphorylase. Ann Hum Genet. 1971 May;34(4):395–408. doi: 10.1111/j.1469-1809.1971.tb00252.x. [DOI] [PubMed] [Google Scholar]
  7. Harris H., Hopkinson D. A., Robson E. B. The incidence of rare alleles determining electrophoretic variants: data on 43 enzyme loci in man. Ann Hum Genet. 1974 Jan;37(3):237–253. doi: 10.1111/j.1469-1809.1974.tb01832.x. [DOI] [PubMed] [Google Scholar]
  8. Hopkinson D. A., Corney G., Cook P. J., Robson E. B., Harris H. Genetically determined electrophoretic variants of human red cell NADH diaphorase. Ann Hum Genet. 1970 Jul;34(1):1–10. doi: 10.1111/j.1469-1809.1970.tb00214.x. [DOI] [PubMed] [Google Scholar]
  9. Morton N. E., Yamamoto M. Blood groups and haptoglobins in the Eastern Carolines. Am J Phys Anthropol. 1973 May;38(3):695–698. doi: 10.1002/ajpa.1330380306. [DOI] [PubMed] [Google Scholar]
  10. Peters J., Hopkinson D. A., Harris H. Genetic and non-genetic variation of triose phosphate isomerase isozymes in human tissues. Ann Hum Genet. 1973 Jan;36(3):297–312. doi: 10.1111/j.1469-1809.1973.tb00592.x. [DOI] [PubMed] [Google Scholar]
  11. Plato C. C., Cruz M. Blood group and haptoglobin frequencies of the Chamorros of Guam. Am J Hum Genet. 1967 Nov;19(6):722–731. [PMC free article] [PubMed] [Google Scholar]
  12. Plato C. C., Cruz M. Blood group and haptoglobin frequencies of the Trukese of Micronesia. Acta Genet Stat Med. 1966;16(1):74–83. doi: 10.1159/000151951. [DOI] [PubMed] [Google Scholar]
  13. SPENCER N., HOPKINSON D. A., HARRIS H. PHOSPHOGLUCOMUTASE POLYMORPHISM IN MAN. Nature. 1964 Nov 21;204:742–745. doi: 10.1038/204742a0. [DOI] [PubMed] [Google Scholar]
  14. Shreffler D. C., Brewer G. J., Gall J. C., Honeyman M. S. Electrophoretic variation in human serum ceruloplasmin: a new genetic polymorphism. Biochem Genet. 1967 Sep;1(2):101–115. doi: 10.1007/BF00486512. [DOI] [PubMed] [Google Scholar]
  15. Sick K., Beale D., Irvine D., Lehmann H., Goodall P. T., MacDougall S. Haemoglobin G Copenhagen and haemoglobin J Cambridge. Two new beta-chain variants of haemoglobin A. Biochim Biophys Acta. 1967 Jun 27;140(2):231–242. doi: 10.1016/0005-2795(67)90463-1. [DOI] [PubMed] [Google Scholar]
  16. Tanis R. J., Neel J. V., Dovey H., Morrow M. The genetic structure of a tribal population, the Yanomama Indians. IX. Gene frequencies for 18 serum protein and erythrocyte enzyme systems in the Yanomama and five neighboring tribes: nine new variants. Am J Hum Genet. 1973 Nov;25(6):655–676. [PMC free article] [PubMed] [Google Scholar]
  17. Tanis R., Ferrell R. E., Nell J. V., Morrow M. Albumin Yanomama-2, a 'private' polymorphism of serum albumin. Ann Hum Genet. 1974 Oct;38(2):179–190. doi: 10.1111/j.1469-1809.1974.tb01949.x. [DOI] [PubMed] [Google Scholar]
  18. Weitkamp L. R., Salzano F. M., Neel J. V., Porta F., Geerdink R. A., Tárnoky A. L. Human serum albumin: twenty-three genetic variants and their population distribution. Ann Hum Genet. 1973 Apr;36(4):381–392. doi: 10.1111/j.1469-1809.1973.tb00602.x. [DOI] [PubMed] [Google Scholar]
  19. Yamamoto M., Fu L. Red cell isozymes in the Eastern Carolines. Am J Phys Anthropol. 1973 May;38(3):703–707. doi: 10.1002/ajpa.1330380308. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES