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. 1981 May;33(3):396–406.

Some epistatic two-locus models of disease. II. The confounding of linkage and association

Susan E Hodge, M Anne Spence
PMCID: PMC1685039  PMID: 6941696

Abstract

This paper continues to examine the model discussed in the preceding paper. Specifically, it will be shown how a linkage analysis performed in the presence of a disease-marker association can give rise to erroneous and misleading results.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbosa J., Chern M. M., Noreen H., Anderson V. E. Analysis of linkage between the major histocompatibility system and juvenile, insulin-dependent diabetes in multiplex families. Reanalysis of data. J Clin Invest. 1978 Aug;62(2):492–495. doi: 10.1172/JCI109151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Darsee J. R., Heymsfield S. B., Nutter D. O. Hypertrophic cardiomyopathy and human leukocyte antigen linkage: differentiation of two forms of hypertrophic cardiomyopathy. N Engl J Med. 1979 Apr 19;300(16):877–882. doi: 10.1056/NEJM197904193001602. [DOI] [PubMed] [Google Scholar]
  3. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hodge S. E. Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs. Am J Hum Genet. 1981 May;33(3):381–395. [PMC free article] [PubMed] [Google Scholar]
  5. Hodge S. E., Spence M. A., Cederbaum S. D. Hypertrophic myocardiopathy. N Engl J Med. 1979 Aug 23;301(8):442–443. doi: 10.1056/NEJM197908233010829. [DOI] [PubMed] [Google Scholar]
  6. Kravitz K., Skolnick M., Cannings C., Carmelli D., Baty B., Amos B., Johnson A., Mendell N., Edwards C., Cartwright G. Genetic linkage between hereditary hemochromatosis and HLA. Am J Hum Genet. 1979 Sep;31(5):601–619. [PMC free article] [PubMed] [Google Scholar]
  7. MORTON N. E. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am J Hum Genet. 1956 Jun;8(2):80–96. [PMC free article] [PubMed] [Google Scholar]
  8. Ott J. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet. 1974 Sep;26(5):588–597. [PMC free article] [PubMed] [Google Scholar]
  9. Sachs J. A., Brewerton D. A. HLA, ankylosing spondylitis and rheumatoid arthritis. Br Med Bull. 1978 Sep;34(3):275–278. doi: 10.1093/oxfordjournals.bmb.a071511. [DOI] [PubMed] [Google Scholar]
  10. Seager K., Bashir H. V., Geczy A. F., Edmonds J., de Vere-Tyndall A. Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature. 1979 Jan 4;277(5691):68–70. doi: 10.1038/277068a0. [DOI] [PubMed] [Google Scholar]
  11. Suarez B., Hodge S. E., Reich T. Is juvenile diabetes determined by a single gene closely linked to HLA? Diabetes. 1979 Jun;28(6):527–532. doi: 10.2337/diab.28.6.527. [DOI] [PubMed] [Google Scholar]
  12. Tiwari J. L., Hodge S. E., Terasaki P. I., Spence M. A. HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees. Am J Hum Genet. 1980 Jan;32(1):103–111. [PMC free article] [PubMed] [Google Scholar]

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