Abstract
Effects of parental consanguinity on morbidity and mortality can be estimated from observations on families ascertained through a child with a disease or defect, provided that appropriate corrections are made for the ascertainment bias. The risk of first-cousin parents having a child with a recessively inherited disease appears to be low (less than 1%). Data obtained by this approach suggest that the increased infant mortality associated with inbreeding (upon which calculations of lethal equivalents are based) may result in part from environmental differences between consanguineous and nonconsanguineous matings, which may be changing. Thus estimates of the number of lethal equivalents in a population can change as the environment changes.
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Selected References
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- Fried K., Davies A. M. Some effects on the offspring of uncle-niece marriage in the Moroccan Jewish community in Jerusalem. Am J Hum Genet. 1974 Jan;26(1):65–72. [PMC free article] [PubMed] [Google Scholar]
- Morton N. E., Crow J. F., Muller H. J. AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A. 1956 Nov;42(11):855–863. doi: 10.1073/pnas.42.11.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts D. F. Cousin marriage. Practitioner. 1974 Nov;213(1277):675–683. [PubMed] [Google Scholar]
- SLATIS H. M., REIS R. H., HOENE R. E. Consanguineous marriages in the Chicago region. Am J Hum Genet. 1958 Dec;10(4):446–464. [PMC free article] [PubMed] [Google Scholar]
- SUTTER J. Recherches sur les effets de la consanguinité chez l'homme. Biol Med (Paris) 1958 Sep-Oct;47(5):563–660. [PubMed] [Google Scholar]
- Schull W. J., Nagano H., Yamamoto M., Komatsu I. The effects of parental consanguinity and inbreeding in Hirado, Japan. I. Stillbirths and prereproductive mortality. Am J Hum Genet. 1970 May;22(3):239–262. [PMC free article] [PubMed] [Google Scholar]
- Yamaguchi M., Yanase T., Nagano H., Nakamoto N. Effects of inbreeding on mortlaity in Fukuoka population. Am J Hum Genet. 1970 Mar;22(2):145–159. [PMC free article] [PubMed] [Google Scholar]