Abstract
A brother and sister have been detected who are homozygous for the bromodeoxyuridine (BrdU)-requiring fragile site at 10q25. The children are phenotypically normal, indicating that homozygosity for this fragile site is harmless, at least during childhood.
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- Berg J. M., Faunch J. A., Pendrey M. J., Penrose L. S., Ridler M. A., Shapiro A. A homozygous chromosomal variant. Lancet. 1969 Mar 8;1(7593):531–531. doi: 10.1016/s0140-6736(69)91627-4. [DOI] [PubMed] [Google Scholar]
- Scheres J. M., Hustinx T. W. Heritable fragile sites and lymphocyte culture medium containing BrdU. Am J Hum Genet. 1980 Jul;32(4):628–629. [PMC free article] [PubMed] [Google Scholar]
- Schmid M., Klett C., Niederhofer A. Demonstration of a heritable fragile site in human chromosome 16 with distamycin A. Cytogenet Cell Genet. 1980;28(1-2):87–94. doi: 10.1159/000131516. [DOI] [PubMed] [Google Scholar]
- Sutherland G. R., Baker E., Seshadri R. S. Heritable fragile sites on human chromosomes. V. A new class of fragile site requiring BrdU for expression. Am J Hum Genet. 1980 Jul;32(4):542–548. [PMC free article] [PubMed] [Google Scholar]
- Sutherland G. R. Heritable fragile sites on human chromosomes II. Distribution, phenotypic effects, and cytogenetics. Am J Hum Genet. 1979 Mar;31(2):136–148. [PMC free article] [PubMed] [Google Scholar]
- Turner G., Brookwell R., Daniel A., Selikowitz M., Zilibowitz M. Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27). N Engl J Med. 1980 Sep 18;303(12):662–664. doi: 10.1056/NEJM198009183031202. [DOI] [PubMed] [Google Scholar]