Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1981 Nov;33(6):894–899.

Evidence for heterosis in the HLA system

Francis L Black, Francisco M Salzano
PMCID: PMC1685167  PMID: 7325154

Abstract

The number of persons with homozygous HLA haplotypes in several groups of South American Indians was 39% less than that expected assuming unmodified equilibrium. In a subpopulation of 122 persons whose parents' HLA constitutions were known, there were 56% fewer homozygous persons than expected. This deficit was widely distributed in different haplotypes and different tribal groups.

Full text

PDF
894

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black F. L., Berman L. L., Gabbay Y. HLA antigens in South American Indians. Tissue Antigens. 1980 Nov;16(5):368–376. doi: 10.1111/j.1399-0039.1980.tb00317.x. [DOI] [PubMed] [Google Scholar]
  2. Black F. L., Salzano F. M., Layrisse Z., Franco M. H., Harris N. S., Weimer T. A. Restriction and persistence of polymorphisms of HLA and other blood genetic traits in the Parakanã Indians of Brazil. Am J Phys Anthropol. 1980 Jan;52(1):119–132. doi: 10.1002/ajpa.1330520115. [DOI] [PubMed] [Google Scholar]
  3. Degos L., Colombani J., Chaventre A., Bengtson B., Jacquard A. Selective pressure on HL-A polymorphism. Nature. 1974 May 3;249(452):62–63. doi: 10.1038/249062a0. [DOI] [PubMed] [Google Scholar]
  4. Layrisse Z., Layrisse M., Heinen H. D., Wilbert J. The histocompatibility system in the Warao indians of venezuela. Science. 1976 Dec 10;194(4270):1135–1138. doi: 10.1126/science.136748. [DOI] [PubMed] [Google Scholar]
  5. Lewontin R. C., Ginzburg L. R., Tuljapurkar S. D. Heterosis as an explanation for large amounts of genic polymorphism. Genetics. 1978 Jan;88(1):149–169. doi: 10.1093/genetics/88.1.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Neel J. V., Gershowitz H., Mohrenweiser H. W., Amos B., Kostyu D. D., Salzano F. M., Mestriner M. A., Lawrence D., Simões A. L., Smouse P. E. Genetic studies on the Ticuna, an enigmatic tribe of Central Amazonas. Ann Hum Genet. 1980 Jul;44(Pt 1):37–54. doi: 10.1111/j.1469-1809.1980.tb00944.x. [DOI] [PubMed] [Google Scholar]
  7. Neel J. V., Ward R. H. Village and tribal genetic distances among American Indians, and the possible implications for human evolution. Proc Natl Acad Sci U S A. 1970 Feb;65(2):323–330. doi: 10.1073/pnas.65.2.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Salzano F. M. Demographic and genetic interrelationships among the Cayapo Indians of Brazil. Soc Biol. 1971 Jun;18(2):148–157. doi: 10.1080/19485565.1971.9987911. [DOI] [PubMed] [Google Scholar]
  9. Salzano F. M., Gershowitz H., Junqueira P. C., Woodall J. P., Black F. L., Hierholzer W. Blood groups and H-Le a salivary secretion of Brazilian Cayapo Indians. Am J Phys Anthropol. 1972 May;36(3):417–425. doi: 10.1002/ajpa.1330360313. [DOI] [PubMed] [Google Scholar]
  10. Salzano F. M., Neel J. V., Weitkamp L. R., Woodall J. P. Serum proteins, hemoglobins and erythrocyte enzymes of Brazilian Cayapo Indians. Hum Biol. 1972 Sep;44(3):443–458. [PubMed] [Google Scholar]
  11. Salzano F. M., Steinberg A. G., Tepfenhart M. A. Gm and Inv allotypes of Brazilian Cayapo Indians. Am J Hum Genet. 1973 Mar;25(2):167–177. [PMC free article] [PubMed] [Google Scholar]
  12. Salzano F. M., Woodall J. P., Black F. L., Weitkamp L. R., Franco M. H. Blood groups, serum proteins and hemoglobins of Brazilian Tiriyo Indians. Hum Biol. 1974 Feb;46(1):81–87. [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES