Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1976 Nov;28(6):597–601.

Distribution of complement C3 variants in individuals with cystic fibrosis.

S Lederberg, D Sackett
PMCID: PMC1685191  PMID: 1008062

Abstract

The gene frequency for slow and fast electrophoretic variants of complement C3 in Caucasian individuals with cystic fibrosis was similar to the values expected for unaffected controls, thereby ruling out a suspected differential involvement of these phenotypes with the disease. In one family, cystic fibrosis and complement C3 phenotypes segregated independently.

Full text

PDF
597

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alper C. A., Propp R. P. Genetic polymorphism of the third component of human complement (C'3). J Clin Invest. 1968 Sep;47(9):2181–2191. doi: 10.1172/JCI105904. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arvilommi H., Berg K., Eriksson A. W. C3 types and their inheritance in Finnish Lapps, Maris (Cheremisses) and Greenland Eskimos. Humangenetik. 1973 May 25;18(3):253–259. doi: 10.1007/BF00290605. [DOI] [PubMed] [Google Scholar]
  3. Azen E. A., Smithies O. Genetic polymorphism of C'3(beta1C-globulin) in human serum. Science. 1968 Nov 22;162(3856):905–907. doi: 10.1126/science.162.3856.905. [DOI] [PubMed] [Google Scholar]
  4. Bowman B. H., Lockhart L. H., McCombs M. L. Oyster ciliary inhibition by cystic fibrosis factor. Science. 1969 Apr 18;164(3877):325–326. doi: 10.1126/science.164.3877.325. [DOI] [PubMed] [Google Scholar]
  5. Conover J. H., Conod E. J., Hirschhorn K. Letter: Complement components in cystic fibrosis. Lancet. 1973 Dec 29;2(7844):1501–1501. doi: 10.1016/s0140-6736(73)92768-2. [DOI] [PubMed] [Google Scholar]
  6. Conover J. H., Conod E. J., Hirschhorn K. Studies on ciliary dyskinesia factor in cystic fibrosis. IV. Its possible identification as anaphylatoxin (C3a)-IgG complex. Life Sci. 1974 Jan 16;14(2):253–266. doi: 10.1016/0024-3205(74)90055-1. [DOI] [PubMed] [Google Scholar]
  7. Conover J. H., Conod E. J. Letter: Complement in cystic fibrosis. Lancet. 1975 Jan 4;1(7897):47–48. doi: 10.1016/s0140-6736(75)92419-8. [DOI] [PubMed] [Google Scholar]
  8. DAVIS B. J. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. Ann N Y Acad Sci. 1964 Dec 28;121:404–427. doi: 10.1111/j.1749-6632.1964.tb14213.x. [DOI] [PubMed] [Google Scholar]
  9. Di Sant'Agnese P. A., Talamo R. D. Pathogenesis and physiopathology of cystic fibrosis of the pancreas. Fibrocystic disease of the pancreas (Mucoviscidosis). N Engl J Med. 1967 Dec 28;277(26):1399+–1399+. doi: 10.1056/NEJM196712282772605. [DOI] [PubMed] [Google Scholar]
  10. Eriksson A. W. Genetic polymorphisms in Finno-Ugrian populations. Finns, Lapps and Maris. Isr J Med Sci. 1973 Sep-Oct;9(9):1156–1170. [PubMed] [Google Scholar]
  11. Farhud D. D., Ananthakrishnan R., Walter H. Association between C'3 phenotypes and various diseases. Humangenetik. 1972;17(1):57–60. [PubMed] [Google Scholar]
  12. Holzhauer R. J., Van Ess J. D., Schwartz R. H. Third component of complement in cystic fibrosis. Am J Hum Genet. 1976 Nov;28(6):602–606. [PMC free article] [PubMed] [Google Scholar]
  13. Kaiser D., Drack E., Rossi E. Effect of cystic-fibrosis sweat on sodium reabsorption by the normao sweat-gland. Lancet. 1970 May 9;1(7654):1003–1003. doi: 10.1016/s0140-6736(70)91130-x. [DOI] [PubMed] [Google Scholar]
  14. Kulczycki L. L., Schauf V. Cystic fibrosis in blacks in Washington, DC: incidence and characteristics. Am J Dis Child. 1974 Jan;127(1):64–67. doi: 10.1001/archpedi.1974.02110200066009. [DOI] [PubMed] [Google Scholar]
  15. Lieberman J. Letter: Complement components in cystic fibrosis. Lancet. 1974 Jun 15;1(7868):1230–1230. doi: 10.1016/s0140-6736(74)91044-7. [DOI] [PubMed] [Google Scholar]
  16. Lieberman J. Plasma arginine esterase activity in cystic fibrosis. Am Rev Respir Dis. 1974 Mar;109(3):399–401. doi: 10.1164/arrd.1974.109.3.399. [DOI] [PubMed] [Google Scholar]
  17. Mangos J. A., McSherry N. R. Sodium transport: inhibitory factor in sweat of patients with cystic fibrosis. Science. 1967 Oct 6;158(3797):135–136. doi: 10.1126/science.158.3797.135. [DOI] [PubMed] [Google Scholar]
  18. Müller-Eberhard H. J. Complement. Annu Rev Biochem. 1975;44:697–724. doi: 10.1146/annurev.bi.44.070175.003405. [DOI] [PubMed] [Google Scholar]
  19. Polley M. J., Bearn A. G. Cystic fibrosis: current concepts. J Med Genet. 1974 Sep;11(3):249–252. doi: 10.1136/jmg.11.3.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rao G. J., Nadler H. L. Arginine esterase in cystic fibrosis of the pancreas. Pediatr Res. 1974 Jun;8(6):684–686. doi: 10.1203/00006450-197406000-00010. [DOI] [PubMed] [Google Scholar]
  21. Rao G. J., Nadler H. L. Deficiency of trypsin-like activity in saliva of patients with cystic fibrosis. J Pediatr. 1972 Apr;80(4):573–576. doi: 10.1016/s0022-3476(72)80052-0. [DOI] [PubMed] [Google Scholar]
  22. Spock A., Heick H. M., Cress H., Logan W. S. Abnormal serum factor in patients with cystic fibrosis of the pancreas. Pediatr Res. 1967 May;1(3):173–177. doi: 10.1203/00006450-196705000-00003. [DOI] [PubMed] [Google Scholar]
  23. Wilson G. B., Fudenberg H. H. Studies on cystic fibrosis using isoelectric focusing. II. Demonstration of deficient proteolytic cleavage of alpha2-macroglobulin in cystic fibrosis plasma. Pediatr Res. 1976 Feb;10(2):87–96. doi: 10.1203/00006450-197602000-00003. [DOI] [PubMed] [Google Scholar]
  24. Wright S. W., Morton N. E. Genetic studies on cystic fibrosis in Hawaii. Am J Hum Genet. 1968 Mar;20(2):157–169. [PMC free article] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES