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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1977 Jan;29(1):31–36.

Comparison of GdA and GdB activities in Nigerians. A study of the variation of the G6PD activity.

G Battistuzzi, G J Esan, F A Fasuan, G Modiano, L Luzzatto
PMCID: PMC1685233  PMID: 835573

Abstract

We report a comparison between G6PD enzyme activities in lysates from GdA and GdB Nigerian healthy males. We confirm the previously reported higher mean activity of G6PD B. An analysis of the enzyme activity variation has been performed: the relative amount of variation found to be associated with this polymorphism is about 8%. A comparison has been made with other genetic polymorphisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Afolayan A., Luzzatto L. Genetic variants of human erythrocyte glucose 6-phosphate dehydrogenase. I. Regulation of activity by oxidized and reduced nicotinamide-adenine dinucleotide phosphate. Biochemistry. 1971 Feb 2;10(3):415–419. doi: 10.1021/bi00779a009. [DOI] [PubMed] [Google Scholar]
  2. Babalola O., Cancedda R., Luzzatto L. Genetic variants of glucose 6-phosphate dehydrogenase from human erythrocytes: unique properties of the A - variant isolated from "deficient" cells. Proc Natl Acad Sci U S A. 1972 Apr;69(4):946–950. doi: 10.1073/pnas.69.4.946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Battistuzzi G., Scozzari R., Santolamazza P., Terrenato L., Modiano G. Comparative activity of red cell adenosine deaminase allelic forms. Nature. 1974 Oct 25;251(5477):711–713. doi: 10.1038/251711a0. [DOI] [PubMed] [Google Scholar]
  4. Bienzle U., Okoye V. C., Gögler H. Haemoglobin and glucose-6-phosphate dehydrogenase variants: distribution in relation to malaria endemicity in a Togolese population. Z Tropenmed Parasitol. 1972 Mar;23(1):56–62. [PubMed] [Google Scholar]
  5. DAVIDSON R. G., CHILDS B., SINISCALCO M. GENETIC VARIATIONS IN THE QUANTITATIVE CONTROL OF ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY. Ann Hum Genet. 1964 Sep;28:61–70. doi: 10.1111/j.1469-1809.1964.tb00460.x. [DOI] [PubMed] [Google Scholar]
  6. Harris H. Enzyme polymorphisms in man. Proc R Soc Lond B Biol Sci. 1966 Mar 22;164(995):298–310. doi: 10.1098/rspb.1966.0032. [DOI] [PubMed] [Google Scholar]
  7. Luzzatto L., Afolayan A. Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants. J Clin Invest. 1968 Aug;47(8):1833–1842. doi: 10.1172/JCI105873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Luzzatto L., Afolayan A. Genetic variants of human erythrocyte glucose 6-phosphate dehydrogenase. II. In vitro and in vivo function of the A- variant. Biochemistry. 1971 Feb 2;10(3):420–423. doi: 10.1021/bi00779a010. [DOI] [PubMed] [Google Scholar]
  9. Luzzatto L., Allan N. C. Relationship between the genes for glucose-6-phosphate dehydrogenase and for haemoglobin in a Nigerian population. Nature. 1968 Sep 7;219(5158):1041–1042. doi: 10.1038/2191041a0. [DOI] [PubMed] [Google Scholar]
  10. Luzzatto L. Genetic factors in malaria. Bull World Health Organ. 1974;50(3-4):195–202. [PMC free article] [PubMed] [Google Scholar]
  11. Luzzatto L. New developments in glucose-6-phosphate dehydrogenase deficiency. Isr J Med Sci. 1973 Sep-Oct;9(9):1484–1498. [PubMed] [Google Scholar]
  12. Luzzatto L. Studies of polymorphic traits for the characterization of populations. African populations south of the Sahara. Isr J Med Sci. 1973 Sep-Oct;9(9):1181–1194. [PubMed] [Google Scholar]
  13. Motulsky A. G., Yoshida A., Stamatoyannopoulos G. Variants of glucose-6-phosphate dehydrogenase. Ann N Y Acad Sci. 1971 Jul 6;179:636–643. doi: 10.1111/j.1749-6632.1971.tb46939.x. [DOI] [PubMed] [Google Scholar]
  14. Panich V., Sungnate T. Characterization of glucose-6-phosphate dehydrogenase in Thailand. The occurrence of 6 variants among 50 G-6-PD deficient Thai. Humangenetik. 1973 Mar 23;18(1):39–46. [PubMed] [Google Scholar]
  15. Siniscalco M., Bernini L., Filippi G., Latte B., Meera Khan P., Piomelli S., Rattazzi M. Population genetics of haemoglobin variants, thalassaemia and glucose-6-phosphate dehydrogenase deficiency, with particular reference to the malaria hypothesis. Bull World Health Organ. 1966;34(3):379–393. [PMC free article] [PubMed] [Google Scholar]
  16. Stamatoyannopoulos G., Kotsakis P., Voigtlander V., Akrivakis A., Moutulsky A. G. Electrophoretic diversity of glucose-6-phosphate dehydrogenase among Greeks. Am J Hum Genet. 1970 Sep;22(5):587–596. [PMC free article] [PubMed] [Google Scholar]
  17. Yoshida A. A single amino Acid substitution (asparagine to aspartic Acid) between normal (b+) and the common negro variant (a+) of human glucose-6-phosphate dehydrogenase. Proc Natl Acad Sci U S A. 1967 Mar;57(3):835–840. doi: 10.1073/pnas.57.3.835. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. van KAMPEN E., ZIJLSTRA W. G. Standardization of hemoglobinometry. II. The hemiglobincyanide method. Clin Chim Acta. 1961 Jul;6:538–544. doi: 10.1016/0009-8981(61)90145-0. [DOI] [PubMed] [Google Scholar]

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