Abstract
The demographic data of children with Cooley's anemia seen at the thalassemia center in Ferrara were analyzed. Survival was studied as a function of several variables, the most interesting being the distance between birthplaces of the parents of affected children. This distance was considered an indicator of genetic distance, and therefore an indicator of residual hybridity of the children. The significant regression of survival on interparental distance might be interpreted as an indicator of increased survival due to residual hybridity. The significant correlation of survival with expected hybridity supports this interpretation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Necheles T. F., Chung S., Sabbah R., Whitten D. Intensive transfusion therapy in thalassemia major: an eight-year follow-up. Ann N Y Acad Sci. 1974;232(0):179–185. doi: 10.1111/j.1749-6632.1974.tb20583.x. [DOI] [PubMed] [Google Scholar]
- WOLMAN I. J. TRANSFUSION THERAPY IN COOLEY'S ANEMIA: GROWTH AND HEALTH AS RELATED TO LONG-RANGE HEMOGLOBIN LEVELS. A PROGRESS REPORT. Ann N Y Acad Sci. 1964 Oct 7;119:736–747. doi: 10.1111/j.1749-6632.1965.tb54075.x. [DOI] [PubMed] [Google Scholar]
- Zanardi P., Dell'Acqua G., Menini C., Barrai I. Population genetics in the province of Ferrara. I. Genetic distances and geographic distances. Am J Hum Genet. 1977 Mar;29(2):169–177. [PMC free article] [PubMed] [Google Scholar]