Skip to main content
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1982 Mar;34(2):245–249.

Anterior segment mesenchymal dysgenesis: Probable linkage to the MNS blood group on chromosome 4

Robert E Ferrell, Helen M Hittner, Frank L Kretzer, James H Antoszyk
PMCID: PMC1685280  PMID: 6978612

Abstract

Thirty-seven blood samples were analyzed for linkage from members of a single family with an anterior segment mesenchymal dysgenesis (ASMD1) with variable expressivity affecting members of at least six generations. Maximum-likelihood analysis for linkage between ASMD1 and 14 biochemical and serological markers in the family showed a probable linkage between ASMD1 and the MNS blood group on the long arm of chromosome 4 (Z = 2.36 at a recombination fraction of .09).

Full text

PDF
245

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker R. F., Hopkinson D. A. Genetic polymorphism of human phosphoglycolate phosphatase (PGP). Ann Hum Genet. 1978 Oct;42(2):143–151. doi: 10.1111/j.1469-1809.1978.tb00644.x. [DOI] [PubMed] [Google Scholar]
  2. Bootsma D., McAlpine P. J. Report of the committee on the genetic constitution of chromosomes 2, 3, 4, and 5. Cytogenet Cell Genet. 1979;25(1-4):21–31. doi: 10.1159/000131396. [DOI] [PubMed] [Google Scholar]
  3. Constans J., Viau M. Group-specific component: evidence for two subtypes of the Gc1 gene. Science. 1977 Dec 9;198(4321):1070–1071. doi: 10.1126/science.73222. [DOI] [PubMed] [Google Scholar]
  4. Ferrell R. E., Bertin T., Barton S. A., Rothhammer F., Schull W. J. The Multinational Andean Genetic and Health Program. IX. Gene frequencies and rare variants of 20 serum proteins and erythrocyte enzymes in the Aymara of Chile. Am J Hum Genet. 1980 Jan;32(1):92–102. [PMC free article] [PubMed] [Google Scholar]
  5. Hittner H. M., Kretzer F. L., Antoszyk J. H., Ferrell R. E., Mehta R. S. Variable expressivity of autosomal dominant anterior segment mesenchymal dysgenesis in six generations. Am J Ophthalmol. 1982 Jan;93(1):57–70. doi: 10.1016/0002-9394(82)90700-0. [DOI] [PubMed] [Google Scholar]
  6. Kenyon K. R., Maumenee A. E. Further studies of congenital hereditary endothelial dystrophy of the cornea. Am J Ophthalmol. 1973 Oct;76(4):419–439. doi: 10.1016/0002-9394(73)90726-5. [DOI] [PubMed] [Google Scholar]
  7. MORTON N. E. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am J Hum Genet. 1956 Jun;8(2):80–96. [PMC free article] [PubMed] [Google Scholar]
  8. Morton N. E. Analysis of crossingover in man. Cytogenet Cell Genet. 1978;22(1-6):15–36. doi: 10.1159/000130916. [DOI] [PubMed] [Google Scholar]
  9. Ott J. Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet. 1974 Sep;26(5):588–597. [PMC free article] [PubMed] [Google Scholar]
  10. Townsend W. M. Congenital corneal leukomas. 1. Central defect in Descemet's membrane. Am J Ophthalmol. 1974 Jan;77(1):80–86. [PubMed] [Google Scholar]
  11. Waring G. O., 3rd, Rodrigues M. M., Laibson P. R. Anterior chamber cleavage syndrome. A stepladder classification. Surv Ophthalmol. 1975 Jul-Aug;20(1):3–27. doi: 10.1016/0039-6257(75)90034-x. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES