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. 1977 May;29(3):256–271.

Inheritance of F cell frequency in heterocellular hereditary persistence of fetal hemoglobin: an example of allelic exclusion.

S H Boyer, L Margolet, M L Boyer, T H Huisman, W A Schroeder, W G Wood, D J Weatherall, J B Clegg, R Cartner
PMCID: PMC1685306  PMID: 868872

Abstract

Two kindreds are described in which F cell frequency is inherited. These families differ in ethnic origin, the mean quantity of HbF per F cell, and in G gamma: A gamma ratios. Heterozygotes have approximately 50% F cells while homozygotes have close to 100%. Semiquantitative single cell immunodiffusion assays establish that F cells contain all of the HbF found in heterozygotes. Our finding that the gene for this heterocellular form of hereditary persistence of fetal hemoglobin is expressed in only half the cells provides the first example of allelic exclusion known apart from immunoglobulin expression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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