Skip to main content
NCBI home page
American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1983 Jan;35(1):58–66.

Studies on the radiosensitivity of cells from patients with basal cell naevus syndrome.

T Featherstone, A M Taylor, D G Harnden
PMCID: PMC1685490  PMID: 6823972

Abstract

No difference in survival was observed between cultured cells from basal cell naevus syndrome (BCNS) patients and normal controls following exposure of fibroblasts to ionizing radiation. Potential lethal damage repair in BCNS cells, measured by holding experiments, was also no different from normal. G0-irradiated lymphocytes from BCNS patients were found to have a significantly higher level of X-ray-induced chromosome aberrations compared with normals. This increase is, however, small, and, taken together with the survival data, suggests that increased cell killing as a measure of the unusual clinical radiosensitivity is not the major effect of the BCNS gene.

Full text

PDF
58

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arlett C. F., Harcourt S. A. Survey of radiosensitivity in a variety of human cell strains. Cancer Res. 1980 Mar;40(3):926–932. [PubMed] [Google Scholar]
  2. Cleaver J. E. Defective repair replication of DNA in xeroderma pigmentosum. Nature. 1968 May 18;218(5142):652–656. doi: 10.1038/218652a0. [DOI] [PubMed] [Google Scholar]
  3. Cox R., Masson W. K., Weichselbaum R. R., Nove J., Little J. B. The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts. Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Apr;39(4):357–365. doi: 10.1080/09553008114550461. [DOI] [PubMed] [Google Scholar]
  4. Cunlift P. N., Mann J. R., Cameron A. H., Roberts K. D., Ward H. N. Radiosensitivity in ataxia-telangiectasia. Br J Radiol. 1975 May;48(569):374–376. doi: 10.1259/0007-1285-48-569-374. [DOI] [PubMed] [Google Scholar]
  5. Inoue T., Hirano K., Yokoiyama A., Kada T., Kato H. DNA repair enzymes in ataxia telangiectasia and Bloom's syndrome fibroblasts. Biochim Biophys Acta. 1977 Dec 14;479(4):497–500. doi: 10.1016/0005-2787(77)90042-9. [DOI] [PubMed] [Google Scholar]
  6. Lehmann A. R. Cancer-associated human genetic diseases with defects in DNA repair. J Cancer Res Clin Oncol. 1981;100(2):117–124. doi: 10.1007/BF00403361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Morten J. E., Harnden D. G., Taylor A. M. Chromosome damage in G0 X-irradiated lymphocytes from patients with hereditary retinoblastoma. Cancer Res. 1981 Sep;41(9 Pt 1):3635–3638. [PubMed] [Google Scholar]
  8. Parrington J. M., Delhanty J. D., Baden H. P. Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV 40 transformation in cultured cells from xeroderma pigmentosum. Ann Hum Genet. 1971 Oct;35(2):149–160. doi: 10.1111/j.1469-1809.1956.tb01387.x. [DOI] [PubMed] [Google Scholar]
  9. Paterson M. C., Smith B. P., Lohman P. H., Anderson A. K., Fishman L. Defective excision repair of gamma-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts. Nature. 1976 Apr 1;260(5550):444–447. doi: 10.1038/260444a0. [DOI] [PubMed] [Google Scholar]
  10. Taylor A. M., Harnden D. G., Arlett C. F., Harcourt S. A., Lehmann A. R., Stevens S., Bridges B. A. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature. 1975 Dec 4;258(5534):427–429. doi: 10.1038/258427a0. [DOI] [PubMed] [Google Scholar]
  11. Taylor A. M., Metcalfe J. A., Oxford J. M., Harnden D. G. Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair? Nature. 1976 Apr 1;260(5550):441–443. doi: 10.1038/260441a0. [DOI] [PubMed] [Google Scholar]
  12. Taylor A. M. Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations. Mutat Res. 1978 Jun;50(3):407–418. doi: 10.1016/0027-5107(78)90045-3. [DOI] [PubMed] [Google Scholar]
  13. Weichselbaum R. R., Nove J., Little J. B. Deficient recovery from potentially lethal radiation damage in ataxia telengiectasia and xeroderma pigmentosum. Nature. 1978 Jan 19;271(5642):261–262. doi: 10.1038/271261a0. [DOI] [PubMed] [Google Scholar]
  14. Weichselbaum R. R., Nove J., Little J. B. X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders. Cancer Res. 1980 Mar;40(3):920–925. [PubMed] [Google Scholar]

Articles from American Journal of Human Genetics are provided here courtesy of American Society of Human Genetics

RESOURCES