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. 1983 Mar;35(2):201–213.

Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system.

N E Morton, A Green, T Dunsworth, A Svejgaard, J Barbosa, S S Rich, L Iselius, P Platz, L P Ryder
PMCID: PMC1685540  PMID: 6573128

Abstract

HLA phenotypes of cases with insulin-dependent diabetes mellitus (IDDM) and identity by descent of HLA haplotypes in affected sib-pairs support an intermediate model in which morbid risk is increased by one HLA-linked IDDM determinant, and greatly increased by two determinants, which may be qualitatively different in DR3 and DR4 haplotypes. Linkage analysis allowing for gametic disequilibrium reveals no recombination in pedigrees with a DR3/DR4 propositus, but spurious recombination in the remaining pedigrees. This evidence favors interaction of unlinked IDDM determinants to produce affection in a small proportion of heterozygotes for an HLA-linked determinant. Partition of data by HLA type of the propositus (ideally by DR and the complement types jointly) is a powerful method to resolve etiological heterogeneity for HLA-associated diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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