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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1978 May;30(3):262–270.

Ethnic variation of genetic disease: roles of drift for recessive lethal genes.

D Wagener, L L Cavalli-Sforza, R Barakat
PMCID: PMC1685590  PMID: 677123

Abstract

Using Wright's distribution of gene frequencies for a recessive lethal gene, a method is given to analyze the probability that any particular gene frequency is greater than a given threshold gene frequency. The method is introduced to analyze the plausibility of drift for explaining observed data.

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Selected References

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  1. Chase G. A., McKusick V. A. Controversy in human genetics: founder effect in Tay-Sachs disease. Am J Hum Genet. 1972 May;24(3):339–340. [PMC free article] [PubMed] [Google Scholar]
  2. Conneally P. M., Merritt A. D., Yu P. L. Cystic fibrosis: population genetics. Tex Rep Biol Med. 1973 Winter;31(4):639–650. [PubMed] [Google Scholar]
  3. Fraikor A. L. Tay-Sachs disease: genetic drift among the Ashkenazim Jews. Soc Biol. 1977 Summer;24(2):117–134. doi: 10.1080/19485565.1977.9988272. [DOI] [PubMed] [Google Scholar]
  4. KOZINN P. J., WIENER H., COHEN P. Infantile amaurotic family idiocy; a genetic approach. J Pediatr. 1957 Jul;51(1):58–64. doi: 10.1016/s0022-3476(57)80282-0. [DOI] [PubMed] [Google Scholar]
  5. McKusick V. A. Clinical genetics at a populational level. The ethnicity of disease in the United States. Ala J Med Sci. 1966 Oct;3(4):408–424. [PubMed] [Google Scholar]
  6. McKusick V. A. Ethnic distribution of disease in non-Jews. Isr J Med Sci. 1973 Sep-Oct;9(9):1375–1382. [PubMed] [Google Scholar]
  7. McKusick V. A. The ethnic distribution of disease in the United States. J Chronic Dis. 1967 Mar;20(3):115–118. doi: 10.1016/0021-9681(67)90045-8. [DOI] [PubMed] [Google Scholar]
  8. Myrianthopoulos N. C., Aronson S. M. Population dynamics of Tay-Sachs disease. I. Reproductive fitness and selection. Am J Hum Genet. 1966 Jul;18(4):313–327. [PMC free article] [PubMed] [Google Scholar]
  9. Myrianthopoulos N. C., Naylor A. F., Aronson S. M. Tay-Sachs disease is probably not increasing. Nature. 1970 Aug 8;227(5258):609–609. doi: 10.1038/227609a0. [DOI] [PubMed] [Google Scholar]
  10. Rao D. C., Morton N. E. Large deviations in the distribution of rare genes. Am J Hum Genet. 1973 Nov;25(6):594–597. [PMC free article] [PubMed] [Google Scholar]
  11. Shaw R. F., Smith A. P. Is Tay-Sachs disease increasing? Nature. 1969 Dec 20;224(5225):1214–1215. doi: 10.1038/2241214b0. [DOI] [PubMed] [Google Scholar]
  12. Shaw R. F., Smith A. P. Is Tay-Sachs disease increasing? Nature. 1969 Dec 20;224(5225):1214–1215. doi: 10.1038/2241214b0. [DOI] [PubMed] [Google Scholar]
  13. Wagener D. K., Cavalli-Sforza L. L. Ethnic variation in genetic disease: possible roles of hitchhiking and epistasis. Am J Hum Genet. 1975 May;27(3):348–364. [PMC free article] [PubMed] [Google Scholar]
  14. Wright S. W., Morton N. E. Genetic studies on cystic fibrosis in Hawaii. Am J Hum Genet. 1968 Mar;20(2):157–169. [PMC free article] [PubMed] [Google Scholar]
  15. Wright S. The Distribution of Gene Frequencies in Populations. Proc Natl Acad Sci U S A. 1937 Jun;23(6):307–320. doi: 10.1073/pnas.23.6.307. [DOI] [PMC free article] [PubMed] [Google Scholar]

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