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. 1983 Sep;35(5):938–950.

Genetic regulation of plasma and red blood cell magnesium concentration in man. II. Segregation analysis.

J M Lalouel, P Darlu, J G Henrotte, D C Rao
PMCID: PMC1685821  PMID: 6614008

Abstract

A previous paper in this series reported that genetic factors play a major role in the familial transmission of plasma (P) and red blood cell (RBC) magnesium (Mg) concentrations. We report here the results of commingling analysis based on a random sample of unrelated individuals, and complex segregation analysis of a random sample of nuclear families. For RBC Mg, there is evidence for a mixture of two distributions, but not for three. For P Mg, there is no evidence for commingling. Complex segregation analysis under a mixed model yielded significant support for a major gene effect on RBC Mg, but not on P Mg. Parameter estimates indicated that the data are compatible with a rather common major gene (q = .23) for elevated RBC Mg, roughly 5% of the population being homozygotes for this gene, that the nonfamilial factors account for a small fraction of the total variance, and that the overlap of distributions of homozygotes is not large.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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