Abstract
Fluorescent markers on chromosome 13 have been used to study familial retinoblastoma. One family showed concordant segregation of a particular chromosome 13 and retinoblastoma from the affected parent to the affected children. In three other families, segregation was discordant. Meiotic crossing over with recombination is proposed as the explanation.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brockhurst R. J., Donaldson D. D. Spontaneous resolution of probable retinoblastoma. Arch Ophthalmol. 1970 Sep;84(3):388–389. doi: 10.1001/archopht.1970.00990040390025. [DOI] [PubMed] [Google Scholar]
- Caspersson T., Lomakka G., Zech L. The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability. Hereditas. 1972;67(1):89–102. doi: 10.1111/j.1601-5223.1971.tb02363.x. [DOI] [PubMed] [Google Scholar]
- Ellsworth R. M. The practical management of retinoblastoma. Trans Am Ophthalmol Soc. 1969;67:462–534. [PMC free article] [PubMed] [Google Scholar]
- Knight L. A., Gardner H. A., Gallie B. L. Segregation of chromosome 13 in retinoblastoma. Lancet. 1978 May 6;1(8071):989–989. doi: 10.1016/s0140-6736(78)90277-5. [DOI] [PubMed] [Google Scholar]
- Knudson A. G., Jr, Meadows A. T., Nichols W. W., Hill R. Chromosomal deletion and retinoblastoma. N Engl J Med. 1976 Nov 11;295(20):1120–1123. doi: 10.1056/NEJM197611112952007. [DOI] [PubMed] [Google Scholar]
- LELE K. P., PENROSE L. S., STALLARD H. B. CHROMOSOME DELETION IN A CASE OF RETINOBLASTOMA. Ann Hum Genet. 1963 Nov;27:171–174. doi: 10.1111/j.1469-1809.1963.tb00209.x. [DOI] [PubMed] [Google Scholar]
- Lin C. C., Gedeon M. M., Griffith P., Smink W. K., Newton D. R., Wilkie L., Sewell L. M. Chromosome analysis on 930 consecutive newborn children using quinacrine fluorescent banding technique. Hum Genet. 1976 Mar 12;31(3):315–328. doi: 10.1007/BF00270861. [DOI] [PubMed] [Google Scholar]
- Sparkes R. S., Muller H., Klisak I. Retinoblastoma with 13q- chromosomal deletion associated with maternal paracentric inversion of 13q. Science. 1979 Mar 9;203(4384):1027–1029. doi: 10.1126/science.424728. [DOI] [PubMed] [Google Scholar]
- Yunis J. J., Ramsay N. Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child. 1978 Feb;132(2):161–163. doi: 10.1001/archpedi.1978.02120270059012. [DOI] [PubMed] [Google Scholar]