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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1980 Nov;32(6):890–897.

HeLa cell identification by analysis of ribosomal DNA segment patterns generated by endonuclease restriction.

R D Schmickel, J R Waterson, M Knoller, L L Szura, G N Wilson
PMCID: PMC1686143  PMID: 6255797

Abstract

Restriction endonuclease analysis of HeLa cells and cells in which origins have been questioned provides evidence in favor of a HeLa cell origin for the questioned cells. Digestion of cellular human DNA reveals a variable ribosomal DNA (rDNA) fragment that is present in up to four discrete sizes. Cell lines of known and suspected HeLa origin contain only two size variants. This pattern of variability serves to distinguish HeLa-derived cells from others. Despite repeated passage and divergence of the HeLa phenotype and karyotype, the restriction pattern is remarkably constant.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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