Skip to main content
PMC home page
The Canadian Veterinary Journal logoLink to The Canadian Veterinary Journal
. 1994 Feb;35(2):86–92.

Pathogenicity of porcine respiratory coronavirus isolated in Québec.

A Jabrane 1, C Girard 1, Y Elazhary 1
PMCID: PMC1686726  PMID: 8069830

Abstract

Porcine respiratory coronavirus (PRCV) is present in many countries, including Canada, but controversy still exists concerning its pathogenicity. Eight-week-old piglets were inoculated intratracheally with a Quebec PRCV isolate (1Q90). Two contact piglets were kept with the inoculated animals. Three animals served as control. Polypnea and dyspnea were the main clinical signs observed. Diffuse bronchioloalveolar damage occurred 24 hours postinoculation. Changes compatible with bronchointerstitial pneumonia were present six days postinoculation. The inoculated virus was recovered from the respiratory tract and mesenteric lymph nodes, but not from the digestive tract, of the inoculated as well as the contact piglets. No virus was isolated from the control piglets. The development of clinical signs and histopathological changes in inoculated as well as in contact piglets and the reisolation of the inoculated virus demonstrated that PRCV can be an important respiratory pathogen.

Full text

PDF
86

Images in this article

88Figure 1.
on p.88
88Figure 2.
on p.88
88Figure 3.
on p.88
88Figure 4.
on p.88

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernard S., Bottreau E., Aynaud J. M., Have P., Szymansky J. Natural infection with the porcine respiratory coronavirus induces protective lactogenic immunity against transmissible gastroenteritis. Vet Microbiol. 1989 Nov;21(1):1–8. doi: 10.1016/0378-1135(89)90013-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown I., Cartwright S. New porcine coronavirus? Vet Rec. 1986 Sep 13;119(11):282–283. doi: 10.1136/vr.119.11.282. [DOI] [PubMed] [Google Scholar]
  3. Callebaut P., Correa I., Pensaert M., Jiménez G., Enjuanes L. Antigenic differentiation between transmissible gastroenteritis virus of swine and a related porcine respiratory coronavirus. J Gen Virol. 1988 Jul;69(Pt 7):1725–1730. doi: 10.1099/0022-1317-69-7-1725. [DOI] [PubMed] [Google Scholar]
  4. Callebaut P., Pensaert M. B., Hooyberghs J. A competitive inhibition ELISA for the differentiation of serum antibodies from pigs infected with transmissible gastroenteritis virus (TGEV) or with the TGEV-related porcine respiratory coronavirus. Vet Microbiol. 1989 May;20(1):9–19. doi: 10.1016/0378-1135(89)90003-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cox E., Hooyberghs J., Pensaert M. B. Sites of replication of a porcine respiratory coronavirus related to transmissible gastroenteritis virus. Res Vet Sci. 1990 Mar;48(2):165–169. doi: 10.1016/S0034-5288(18)30984-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Elazhary Y., Jabrane A., Talbot B. G. Porcine respiratory coronavirus isolated from young piglets in Quebec. Vet Rec. 1992 May 30;130(22):500–500. doi: 10.1136/vr.130.22.500-a. [DOI] [PubMed] [Google Scholar]
  7. Garwes D. J., Stewart F., Cartwright S. F., Brown I. Differentiation of porcine coronavirus from transmissible gastroenteritis virus. Vet Rec. 1988 Jan 23;122(4):86–87. doi: 10.1136/vr.122.4.86. [DOI] [PubMed] [Google Scholar]
  8. Gottschalk M., Higgins R., Jacques M., Beaudoin M., Henrichsen J. Isolation and characterization of Streptococcus suis capsular types 9-22. J Vet Diagn Invest. 1991 Jan;3(1):60–65. doi: 10.1177/104063879100300113. [DOI] [PubMed] [Google Scholar]
  9. Gottschalk M., Higgins R., Jacques M., Mittal K. R., Henrichsen J. Description of 14 new capsular types of Streptococcus suis. J Clin Microbiol. 1989 Dec;27(12):2633–2636. doi: 10.1128/jcm.27.12.2633-2636.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Higgins R., Gottschalk M., Mittal K. R., Beaudoin M. Streptococcus suis infection in swine. A sixteen month study. Can J Vet Res. 1990 Jan;54(1):170–173. [PMC free article] [PubMed] [Google Scholar]
  11. Hooper B. E., Haelterman E. O. Lesions of the gastrointestinal tract of pigs infected with transmissible gastroenteritis. Can J Comp Med. 1969 Jan;33(1):29–36. [PMC free article] [PubMed] [Google Scholar]
  12. Jabrane A., Elazhary Y., Talbot B. G., Ethier R., Dubuc C., Assaf R. Porcine respiratory coronavirus in Quebec: Serological studies using a competitive inhibition enzyme-linked immunosorbent assay. Can Vet J. 1992 Nov;33(11):727–733. [PMC free article] [PubMed] [Google Scholar]
  13. Kemeny L. J., Wiltsey V. L., Riley J. L. Upper respiratory infection of lactating sows with transmissible gastroenteritis virus following contact exposure to infected piglets. Cornell Vet. 1975 Jul;65(3):352–362. [PubMed] [Google Scholar]
  14. O'Toole D., Brown I., Bridges A., Cartwright S. F. Pathogenicity of experimental infection with 'pneumotropic' porcine coronavirus. Res Vet Sci. 1989 Jul;47(1):23–29. doi: 10.1016/S0034-5288(18)31226-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Onno M., Jestin A., Cariolet R., Vannier P. Rapid diagnosis of TGEV-like coronavirus in fattened pigs by indirect immunofluorescence labelling in nasal cells. Zentralbl Veterinarmed B. 1989 Oct;36(8):629–634. doi: 10.1111/j.1439-0450.1989.tb00654.x. [DOI] [PubMed] [Google Scholar]
  16. Pensaert M., Callebaut P., Vergote J. Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis. Vet Q. 1986 Jul;8(3):257–261. doi: 10.1080/01652176.1986.9694050. [DOI] [PubMed] [Google Scholar]
  17. Siddell S., Wege H., Ter Meulen V. The biology of coronaviruses. J Gen Virol. 1983 Apr;64(Pt 4):761–776. doi: 10.1099/0022-1317-64-4-761. [DOI] [PubMed] [Google Scholar]
  18. Wesley R. D., Woods R. D., Hill H. T., Biwer J. D. Evidence for a porcine respiratory coronavirus, antigenically similar to transmissible gastroenteritis virus, in the United States. J Vet Diagn Invest. 1990 Oct;2(4):312–317. doi: 10.1177/104063879000200411. [DOI] [PubMed] [Google Scholar]
  19. Yus E., Laviada M. D., Moreno L., Castro J. M., Escribano J. M., Simarro I. Prevalencia de anticuerpos frente a virus influenza y coronavirus respiratorio en cerdos de cebo en España. Zentralbl Veterinarmed B. 1989 Sep;36(7):551–556. [PubMed] [Google Scholar]
  20. van Nieuwstadt A. P., Pol J. M. Isolation of a TGE virus-related respiratory coronavirus causing fatal pneumonia in pigs. Vet Rec. 1989 Jan 14;124(2):43–44. doi: 10.1136/vr.124.2.43. [DOI] [PubMed] [Google Scholar]

Articles from The Canadian Veterinary Journal are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES