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. 1976 Sep 11;2(6036):612–615. doi: 10.1136/bmj.2.6036.612

Bleeding in renal failure: a possible cause.

M Kazatchkine, Y Sultan, J P Caen, J Bariety
PMCID: PMC1688205  PMID: 786433

Abstract

Increased concentrations of factor VIII-related antigen (VIIIRA), factor VIII-procoagulant activity (VIIC), and decreased factor VII-von Willebrand activity (VIIIVWF) were found in the plasma of patients with chronic renal failure (CRF). This functional abnormality of the factor VII protein may partly explain the prolonged bleeding time commonly found in CRF. It was not improved by dialysis, but it was no longer found in patients with normally functioning grafted kidneys after the sixth month after transplantation. VIIIVWF levels remained decreased when compared with VIIIRA or VIIIC in transplanted patients undergoing acute reversible rejection soon after transplantation. Yet, not only VIIIC and VIIIRA but also VIIIVWF were greatly increased in patients with hyperacute irreversible rejection. Possibly a high VIIIVWF level in these patients is a thrombogenic factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boneu B., Abbal M., Plante J., Bierme R. Letter: Factor-VIII complex and endothelial damage. Lancet. 1975 Jun 28;1(7922):1430–1430. doi: 10.1016/s0140-6736(75)92650-1. [DOI] [PubMed] [Google Scholar]
  2. Bouma B. N., Wiegerinck Y., Sixma J. J., Van Mourik J. A., Mochtar I. A. Immunological characterization of purified anti-haemophilic factor A (factor VIII) which corrects abnormal platelet retention in Von Willebrand's disease. Nat New Biol. 1972 Mar 29;236(65):104–106. doi: 10.1038/newbio236104a0. [DOI] [PubMed] [Google Scholar]
  3. Castaldi P. A., Rozenberg M. C., Stewart J. H. The bleeding disorder of uraemia. A qualitative platelet defect. Lancet. 1966 Jul 9;2(7454):66–69. doi: 10.1016/s0140-6736(66)91802-2. [DOI] [PubMed] [Google Scholar]
  4. Evans E. P., Branch R. A., Bloom A. L. A clinical and experimental study of platelet function in chronic renal failure. J Clin Pathol. 1972 Sep;25(9):745–753. doi: 10.1136/jcp.25.9.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Holmberg L., Nilsson I. M. AHF related protein in clinical praxis. Scand J Haematol. 1974;12(3):221–231. doi: 10.1111/j.1600-0609.1974.tb00202.x. [DOI] [PubMed] [Google Scholar]
  6. Horowitz H. I., Stein I. M., Cohen B. D., White J. G. Further studies on the platelet-inhibitory effect of guanidinosuccinic acid and its role in uremic bleeding. Am J Med. 1970 Sep;49(3):336–345. doi: 10.1016/s0002-9343(70)80025-0. [DOI] [PubMed] [Google Scholar]
  7. Hoyer J. R., Michael A. F., Hoyer L. W. Immunofluorescent localization of antihemophilic factor antigen and fibrinogen in human renal diseases. J Clin Invest. 1974 May;53(5):1375–1384. doi: 10.1172/JCI107686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jaffe E. A., Nachman R. L. Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells. J Clin Invest. 1975 Sep;56(3):698–702. doi: 10.1172/JCI108140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Marchesi S. L., Shulman N. R., Gralnick H. R. Studies on the purification and characterization of human factor 8. J Clin Invest. 1972 Aug;51(8):2151–2161. doi: 10.1172/JCI107022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sultan Y., Simeon J., Caen J. P. Detection of heterozygotes in both parents of homozygous patients with Von Willebrand's disease. J Clin Pathol. 1975 Apr;28(4):309–316. doi: 10.1136/jcp.28.4.309. [DOI] [PMC free article] [PubMed] [Google Scholar]

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