Abstract
Ventricular fibrillation is the major cause of sudden cardiac death, the leading cause of death in the industrialized world; however, the mechanisms for its onset are not well understood. To further understand the dynamics of fibrillation at and near its onset, we compared spatial and temporal variability of mean interactivation intervals in a stable canine model for ventricular fibrillation. Temporal variability was very small, suggesting that the relevant physiological parameters remained constant during our experiments. Spatial variability was usually significantly larger and appeared incompatible with the dynamics of a single, meandering spiral wave. This confirmed recent results that a single spiral wave cannot generate ventricular fibrillation. Thus the onset of fibrillation is a multistage process, with spiral-wave breakdown providing a crucial step in the quasi-periodic route to fibrillation.
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Selected References
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- Barkley D. Linear stability analysis of rotating spiral waves in excitable media. Phys Rev Lett. 1992 Mar 30;68(13):2090–2093. doi: 10.1103/PhysRevLett.68.2090. [DOI] [PubMed] [Google Scholar]
- Bayly P. V., Johnson E. E., Wolf P. D., Greenside H. S., Smith W. M., Ideker R. E. A quantitative measurement of spatial order in ventricular fibrillation. J Cardiovasc Electrophysiol. 1993 Oct;4(5):533–546. doi: 10.1111/j.1540-8167.1993.tb01242.x. [DOI] [PubMed] [Google Scholar]
- Damle R. S., Kanaan N. M., Robinson N. S., Ge Y. Z., Goldberger J. J., Kadish A. H. Spatial and temporal linking of epicardial activation directions during ventricular fibrillation in dogs. Evidence for underlying organization. Circulation. 1992 Nov;86(5):1547–1558. doi: 10.1161/01.cir.86.5.1547. [DOI] [PubMed] [Google Scholar]
- Fenton Flavio, Karma Alain. Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation. Chaos. 1998 Mar;8(1):20–47. doi: 10.1063/1.166311. [DOI] [PubMed] [Google Scholar]
- Gray R. A., Jalife J., Panfilov A. V., Baxter W. T., Cabo C., Davidenko J. M., Pertsov A. M. Mechanisms of cardiac fibrillation. Science. 1995 Nov 17;270(5239):1222–1225. [PubMed] [Google Scholar]
- Gray R. A., Pertsov A. M., Jalife J. Spatial and temporal organization during cardiac fibrillation. Nature. 1998 Mar 5;392(6671):75–78. doi: 10.1038/32164. [DOI] [PubMed] [Google Scholar]
- Karma A. Meandering transition in two-dimensional excitable media. Phys Rev Lett. 1990 Nov 26;65(22):2824–2827. doi: 10.1103/PhysRevLett.65.2824. [DOI] [PubMed] [Google Scholar]
- Nwasokwa O. N., Bodenheimer M. M. Global analysis of myocardial isotonic shortening: comparison with isometric dynamics. Am J Physiol. 1991 Feb;260(2 Pt 2):H486–H498. doi: 10.1152/ajpheart.1991.260.2.H486. [DOI] [PubMed] [Google Scholar]
- Nwasokwa O. N. Dynamics of cardiac muscle: analysis of isotonic, isometric, and isochronal curves. Am J Physiol. 1987 Sep;253(3 Pt 2):H645–H653. doi: 10.1152/ajpheart.1987.253.3.H645. [DOI] [PubMed] [Google Scholar]
- Panfilov A. V., Hogeweg P. Mechanisms of cardiac fibrillation. Science. 1995 Nov 17;270(5239):1223–1225. [PubMed] [Google Scholar]
- Witkowski F. X., Leon L. J., Penkoske P. A., Giles W. R., Spano M. L., Ditto W. L., Winfree A. T. Spatiotemporal evolution of ventricular fibrillation. Nature. 1998 Mar 5;392(6671):78–82. doi: 10.1038/32170. [DOI] [PubMed] [Google Scholar]