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. 1976 Nov 27;2(6047):1284–1287. doi: 10.1136/bmj.2.6047.1284

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods.

F A Drasar, W Farrell, J Maskell, J D Williams
PMCID: PMC1690042  PMID: 1000196

Abstract

Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crowe C. C., Sanders E. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3(1):24–28. doi: 10.1128/aac.3.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. George R. H., Healing D. E. Letter: Gentamicin resistance. Lancet. 1976 Jan 31;1(7953):258–258. doi: 10.1016/s0140-6736(76)91391-x. [DOI] [PubMed] [Google Scholar]
  3. Klastersky J., Henri A., Hensgens C., Vandenborre L., Daneau D. Antipseudomonal drugs: comparative study of gentamicin, sisomicin and tobramycin in vitro and in human volunteers. Eur J Cancer. 1973 Sep;9(9):641–648. doi: 10.1016/0014-2964(73)90006-6. [DOI] [PubMed] [Google Scholar]
  4. Meyer R. D., Lewis R. P., Carmalt E. D., Finegold S. M. Amikacin therapy for serious gram-negative bacillary infections. Ann Intern Med. 1975 Dec;83(6):790–800. doi: 10.7326/0003-4819-83-6-790. [DOI] [PubMed] [Google Scholar]
  5. Meyer R. D., Lewis R. P., Halter J., White M. Gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens in a general hospital. Lancet. 1976 Mar 13;1(7959):580–583. doi: 10.1016/s0140-6736(76)90370-6. [DOI] [PubMed] [Google Scholar]
  6. Price K. E., Godfrey J. C. Effect of structural modifications on the biological properties of aminoglycoside antibiotics containing 2-deoxystreptamine. Adv Appl Microbiol. 1974;18(0):191–307. doi: 10.1016/s0065-2164(08)70572-0. [DOI] [PubMed] [Google Scholar]
  7. Reynolds A. V., Hamilton-Miller J. M., Brumfitt W. Newer aminoglycosides--amikacin and tobramycin: an in-vitro comparison with kanamycin and gentamicin. Br Med J. 1974 Sep 28;3(5934):778–780. doi: 10.1136/bmj.3.5934.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Roe E., Lowbury E. J. Changes in antibiotic sensitivity patterns of Gram-negative bacilli in burns. J Clin Pathol. 1972 Feb;25(2):176–178. doi: 10.1136/jcp.25.2.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Waitz J. A., Moss E. L., Jr, Drube C. G., Weinstein M. J. Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin. Antimicrob Agents Chemother. 1972 Dec;2(6):431–437. doi: 10.1128/aac.2.6.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Waterworth P. M. The in-vitro activity of tobramycin compared with that of other aminoglycosides. J Clin Pathol. 1972 Nov;25(11):979–983. doi: 10.1136/jcp.25.11.979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Weinstein R. J., Young L. S., Hewitt W. L. Activity of three aminoglycosides and two penicillins against four species of gram-negative bacilli. Antimicrob Agents Chemother. 1975 Feb;7(2):172–178. doi: 10.1128/aac.7.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]

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