Abstract
In a population with overlapping generations, intense selection can perturb the age distribution and thus affect the rate of increase of an advantageous allele. We found that the age-specific nature of intense selection, such as that generated by many diseases, can affect the outcome of selection on loci, such as those conferring disease resistance. We also found that the temporal dynamics of selection alter the speed of evolution, particularly when selection is intense, and even more so when it is age-specific. We relate our model and results to selection for disease resistance, although the results have broader implications for inferences about past selection pressures in general.
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Selected References
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- Bauch Chris T., Earn David J. D. Transients and attractors in epidemics. Proc Biol Sci. 2003 Aug 7;270(1524):1573–1578. doi: 10.1098/rspb.2003.2410. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ferguson Neil M., Galvani Alison P., Bush Robin M. Ecological and immunological determinants of influenza evolution. Nature. 2003 Mar 27;422(6930):428–433. doi: 10.1038/nature01509. [DOI] [PubMed] [Google Scholar]
- Galvani Alison P., Lei Xiudong, Jewell Nicholas P. Severe acute respiratory syndrome: temporal stability and geographic variation in case-fatality rates and doubling times. Emerg Infect Dis. 2003 Aug;9(8):991–994. doi: 10.3201/eid0908.030334. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keyfitz N. On the momentum of population growth. Demography. 1971 Feb;8(1):71–80. [PubMed] [Google Scholar]
- Reid A. H., Fanning T. G., Hultin J. V., Taubenberger J. K. Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1651–1656. doi: 10.1073/pnas.96.4.1651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stephens J. C., Reich D. E., Goldstein D. B., Shin H. D., Smith M. W., Carrington M., Winkler C., Huttley G. A., Allikmets R., Schriml L. Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet. 1998 Jun;62(6):1507–1515. doi: 10.1086/301867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tognetti K. Some extensions of the Keyfitz momentum relationship. Demography. 1976 Nov;13(4):507–512. [PubMed] [Google Scholar]