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Philosophical Transactions of the Royal Society B: Biological Sciences logoLink to Philosophical Transactions of the Royal Society B: Biological Sciences
. 1997 Nov 29;352(1362):1747–1754. doi: 10.1098/rstb.1997.0157

Transient global amnesia and functional retrograde amnesia: contrasting examples of episodic memory loss.

M Kritchevsky 1, J Zouzounis 1, L R Squire 1
PMCID: PMC1692097  PMID: 9415927

Abstract

We studied 11 patients with transient global amnesia (TGA) and ten patients with functional retrograde amnesia (FRA). Patients with TGA had a uniform clinical picture: a severe, relatively isolated amnesic syndrome that started suddenly, persisted for 4-12 h, and then gradually improved to essentially normal over the next 12-24 h. During the episode, the patients had severe anterograde amnesia for verbal and non-verbal material and retrograde amnesia that typically covered at least two decades. Thirty hours to 42 days after the episode, the patients had recovered completely and performed normally on tests of anterograde and retrograde amnesia. By contrast, patients with FRA had a sudden onset of memory problems that were characterized by severe retrograde amnesia without associated anterograde amnesia and with a clinical presentation that otherwise varied considerably. The episodes persisted from several weeks to more than two years, and some of the patients had not recovered at the time of our last contact with them. The uniform clinical picture of TGA and the variable clinical picture of FRA presumably reflect their respective neurologic ('organic') and psychogenic ('non-organic') aetiologies.

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Selected References

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  1. COURJON J., GUYOTAT J. Les ictus amnésiques. J Med Lyon. 1956 Oct 5;37(882):697–701. [PubMed] [Google Scholar]
  2. Campodonico J. R., Rediess S. Dissociation of implicit and explicit knowledge in a case of psychogenic retrograde amnesia. J Int Neuropsychol Soc. 1996 Mar;2(2):146–158. doi: 10.1017/s1355617700001004. [DOI] [PubMed] [Google Scholar]
  3. Catalano F. L. A preliminary report on a new memory scale. Percept Mot Skills. 1968 Aug;27(1):277–278. doi: 10.2466/pms.1968.27.1.277. [DOI] [PubMed] [Google Scholar]
  4. De Renzi E., Lucchelli F., Muggia S., Spinnler H. Persistent retrograde, amnesia following a minor trauma. Cortex. 1995 Sep;31(3):531–542. doi: 10.1016/s0010-9452(13)80064-0. [DOI] [PubMed] [Google Scholar]
  5. Donaldson I. M. "Psychometric" assessment during transient global amnesia. Cortex. 1985 Mar;21(1):149–152. doi: 10.1016/s0010-9452(85)80022-8. [DOI] [PubMed] [Google Scholar]
  6. Evans J., Wilson B., Wraight E. P., Hodges J. R. Neuropsychological and SPECT scan findings during and after transient global amnesia: evidence for the differential impairment of remote episodic memory. J Neurol Neurosurg Psychiatry. 1993 Nov;56(11):1227–1230. doi: 10.1136/jnnp.56.11.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fisher C. M. Transient global amnesia. Precipitating activities and other observations. Arch Neurol. 1982 Oct;39(10):605–608. doi: 10.1001/archneur.1982.00510220003001. [DOI] [PubMed] [Google Scholar]
  8. Frederiks J. A. Transient global amnesia. Clin Neurol Neurosurg. 1993 Dec;95(4):265–283. doi: 10.1016/0303-8467(93)90102-m. [DOI] [PubMed] [Google Scholar]
  9. Gallassi R., Lorusso S., Stracciari A. Neuropsychological findings during a transient global amnesia attack and its follow-up. Ital J Neurol Sci. 1986 Feb;7(1):45–49. doi: 10.1007/BF02230416. [DOI] [PubMed] [Google Scholar]
  10. Gallassi R., Stracciari A., Morreale A., Lorusso S., Rebucci G. G., Lugaresi E. Transient global amnesia: neuropsychological findings after single and multiple attacks. Eur Neurol. 1993;33(4):294–298. doi: 10.1159/000116957. [DOI] [PubMed] [Google Scholar]
  11. Goldenberg G., Podreka I., Pfaffelmeyer N., Wessely P., Deecke L. Thalamic ischemia in transient global amnesia: a SPECT study. Neurology. 1991 Nov;41(11):1748–1752. doi: 10.1212/wnl.41.11.1748. [DOI] [PubMed] [Google Scholar]
  12. Gordon B., Marin O. S. Transient global amnesia: an extensive case report. J Neurol Neurosurg Psychiatry. 1979 Jun;42(6):572–575. doi: 10.1136/jnnp.42.6.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hinge H. H., Jensen T. S., Kjaer M., Marquardsen J., de Fine Olivarius B. The prognosis of transient global amnesia. Results of a multicenter study. Arch Neurol. 1986 Jul;43(7):673–676. doi: 10.1001/archneur.1986.00520070031013. [DOI] [PubMed] [Google Scholar]
  14. Hodges J. R., Oxbury S. M. Persistent memory impairment following transient global amnesia. J Clin Exp Neuropsychol. 1990 Dec;12(6):904–920. doi: 10.1080/01688639008401030. [DOI] [PubMed] [Google Scholar]
  15. Hodges J. R. Semantic memory and frontal executive function during transient global amnesia. J Neurol Neurosurg Psychiatry. 1994 May;57(5):605–608. doi: 10.1136/jnnp.57.5.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hodges J. R., Ward C. D. Observations during transient global amnesia. A behavioural and neuropsychological study of five cases. Brain. 1989 Jun;112(Pt 3):595–620. doi: 10.1093/brain/112.3.595. [DOI] [PubMed] [Google Scholar]
  17. Hodges J. R., Warlow C. P. The aetiology of transient global amnesia. A case-control study of 114 cases with prospective follow-up. Brain. 1990 Jun;113(Pt 3):639–657. doi: 10.1093/brain/113.3.639. [DOI] [PubMed] [Google Scholar]
  18. Kapur N., Ellison D., Parkin A. J., Hunkin N. M., Burrows E., Sampson S. A., Morrison E. A. Bilateral temporal lobe pathology with sparing of medial temporal lobe structures: lesion profile and pattern of memory disorder. Neuropsychologia. 1994 Jan;32(1):23–38. doi: 10.1016/0028-3932(94)90066-3. [DOI] [PubMed] [Google Scholar]
  19. Kapur N., Ellison D., Smith M. P., McLellan D. L., Burrows E. H. Focal retrograde amnesia following bilateral temporal lobe pathology. A neuropsychological and magnetic resonance study. Brain. 1992 Feb;115(Pt 1):73–85. doi: 10.1093/brain/115.1.73. [DOI] [PubMed] [Google Scholar]
  20. Kapur N. Focal retrograde amnesia in neurological disease: a critical review. Cortex. 1993 Jun;29(2):217–234. doi: 10.1016/s0010-9452(13)80177-3. [DOI] [PubMed] [Google Scholar]
  21. Kaszniak A. W., Nussbaum P. D., Berren M. R., Santiago J. Amnesia as a consequence of male rape: a case report. J Abnorm Psychol. 1988 Feb;97(1):100–104. doi: 10.1037//0021-843x.97.1.100. [DOI] [PubMed] [Google Scholar]
  22. Kelly D. Clinical review of beta-blockers in anxiety. Pharmakopsychiatr Neuropsychopharmakol. 1980 Sep;13(5):259–266. doi: 10.1055/s-2007-1019643. [DOI] [PubMed] [Google Scholar]
  23. Kopelman M. D., Christensen H., Puffett A., Stanhope N. The great escape: a neuropsychological study of psychogenic amnesia. Neuropsychologia. 1994 Jun;32(6):675–691. doi: 10.1016/0028-3932(94)90028-0. [DOI] [PubMed] [Google Scholar]
  24. Kopelman M. D., Wilson B. A., Baddeley A. D. The autobiographical memory interview: a new assessment of autobiographical and personal semantic memory in amnesic patients. J Clin Exp Neuropsychol. 1989 Oct;11(5):724–744. doi: 10.1080/01688638908400928. [DOI] [PubMed] [Google Scholar]
  25. Koski K. J., Marttila R. J. Transient global amnesia: incidence in an urban population. Acta Neurol Scand. 1990 Apr;81(4):358–360. doi: 10.1111/j.1600-0404.1990.tb01571.x. [DOI] [PubMed] [Google Scholar]
  26. Kritchevsky M., Squire L. R. Transient global amnesia: evidence for extensive, temporally graded retrograde amnesia. Neurology. 1989 Feb;39(2 Pt 1):213–218. doi: 10.1212/wnl.39.2.213. [DOI] [PubMed] [Google Scholar]
  27. Kritchevsky M., Squire L. R., Zouzounis J. A. Transient global amnesia: characterization of anterograde and retrograde amnesia. Neurology. 1988 Feb;38(2):213–219. doi: 10.1212/wnl.38.2.213. [DOI] [PubMed] [Google Scholar]
  28. Kritchevsky M. Transient global amnesia. When memory temporarily disappears. Postgrad Med. 1987 Jul;82(1):95-7, 100. doi: 10.1080/00325481.1987.11699897. [DOI] [PubMed] [Google Scholar]
  29. Lin K. N., Liu R. S., Yeh T. P., Wang S. J., Liu H. C. Posterior ischemia during an attack of transient global amnesia. Stroke. 1993 Jul;24(7):1093–1095. doi: 10.1161/01.str.24.7.1093. [DOI] [PubMed] [Google Scholar]
  30. Lucchelli F., Muggia S., Spinnler H. The 'Petites Madeleines' phenomenon in two amnesic patients. sudden recovery of forgotten memories. Brain. 1995 Feb;118(Pt 1):167–183. doi: 10.1093/brain/118.1.167. [DOI] [PubMed] [Google Scholar]
  31. Markowitsch H. J., Calabrese P., Haupts M., Durwen H. F., Liess J., Gehlen W. Searching for the anatomical basis of retrograde amnesia. J Clin Exp Neuropsychol. 1993 Nov;15(6):947–967. doi: 10.1080/01688639308402610. [DOI] [PubMed] [Google Scholar]
  32. Meador K. J., Loring D. W., King D. W., Nichols F. T. The P3 evoked potential and transient global amnesia. Arch Neurol. 1988 Apr;45(4):465–467. doi: 10.1001/archneur.1988.00520280119029. [DOI] [PubMed] [Google Scholar]
  33. Miller J. W., Petersen R. C., Metter E. J., Millikan C. H., Yanagihara T. Transient global amnesia: clinical characteristics and prognosis. Neurology. 1987 May;37(5):733–737. doi: 10.1212/wnl.37.5.733. [DOI] [PubMed] [Google Scholar]
  34. Nausieda P. A., Sherman I. V. Long-term prognosis in transient global amnesia. JAMA. 1979 Jan 26;241(4):392–393. [PubMed] [Google Scholar]
  35. Patten B. M. Transient global amnesia syndrome. JAMA. 1971 Aug 2;217(5):690–690. [PubMed] [Google Scholar]
  36. Regard M., Landis T. Transient global amnesia: neuropsychological dysfunction during attack and recovery in two "pure" cases. J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):668–672. doi: 10.1136/jnnp.47.7.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Rempel-Clower N. L., Zola S. M., Squire L. R., Amaral D. G. Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation. J Neurosci. 1996 Aug 15;16(16):5233–5255. doi: 10.1523/JNEUROSCI.16-16-05233.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Schacter D. L., Wang P. L., Tulving E., Freedman M. Functional retrograde amnesia: a quantitative case study. Neuropsychologia. 1982;20(5):523–532. doi: 10.1016/0028-3932(82)90026-4. [DOI] [PubMed] [Google Scholar]
  39. Shuping J. R., Rollinson R. D., Toole J. F. Transient global amnesia. Ann Neurol. 1980 Mar;7(3):281–285. doi: 10.1002/ana.410070313. [DOI] [PubMed] [Google Scholar]
  40. Shuttleworth E. C., Wise G. R. Transient global amnesia due to arterial embolism. Arch Neurol. 1973 Nov;29(5):340–342. doi: 10.1001/archneur.1973.00490290080011. [DOI] [PubMed] [Google Scholar]
  41. Squire L. R., Haist F., Shimamura A. P. The neurology of memory: quantitative assessment of retrograde amnesia in two groups of amnesic patients. J Neurosci. 1989 Mar;9(3):828–839. doi: 10.1523/JNEUROSCI.09-03-00828.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Squire L. R., Shimamura A. P. Characterizing amnesic patients for neurobehavioral study. Behav Neurosci. 1986 Dec;100(6):866–877. doi: 10.1037//0735-7044.100.6.866. [DOI] [PubMed] [Google Scholar]
  43. Stillhard G., Landis T., Schiess R., Regard M., Sialer G. Bitemporal hypoperfusion in transient global amnesia: 99m-Tc-HM-PAO SPECT and neuropsychological findings during and after an attack. J Neurol Neurosurg Psychiatry. 1990 Apr;53(4):339–342. doi: 10.1136/jnnp.53.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Stracciari A., Rebucci G. G., Gallassi R. Transient global amnesia: neuropsychological study of a "pure" case. J Neurol. 1987 Feb;234(2):126–127. doi: 10.1007/BF00314119. [DOI] [PubMed] [Google Scholar]
  45. Zola-Morgan S., Cohen N. J., Squire L. R. Recall of remote episodic memory in amnesia. Neuropsychologia. 1983;21(5):487–500. doi: 10.1016/0028-3932(83)90005-2. [DOI] [PubMed] [Google Scholar]
  46. Zorzon M., Antonutti L., Masè G., Biasutti E., Vitrani B., Cazzato G. Transient global amnesia and transient ischemic attack. Natural history, vascular risk factors, and associated conditions. Stroke. 1995 Sep;26(9):1536–1542. doi: 10.1161/01.str.26.9.1536. [DOI] [PubMed] [Google Scholar]

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