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Philosophical Transactions of the Royal Society B: Biological Sciences logoLink to Philosophical Transactions of the Royal Society B: Biological Sciences
. 2000 Dec 29;355(1404):1771–1788. doi: 10.1098/rstb.2000.0734

Abnormalities in the awareness and control of action.

C D Frith 1, S J Blakemore 1, D M Wolpert 1
PMCID: PMC1692910  PMID: 11205340

Abstract

Much of the functioning of the motor system occurs without awareness. Nevertheless, we are aware of some aspects of the current state of the system and we can prepare and make movements in the imagination. These mental representations of the actual and possible states of the system are based on two sources: sensory signals from skin and muscles, and the stream of motor commands that have been issued to the system. Damage to the neural substrates of the motor system can lead to abnormalities in the awareness of action as well as defects in the control of action. We provide a framework for understanding how these various abnormalities of awareness can arise. Patients with phantom limbs or with anosognosia experience the illusion that they can move their limbs. We suggest that these representations of movement are based on streams of motor commands rather than sensory signals. Patients with utilization behaviour or with delusions of control can no longer properly link their intentions to their actions. In these cases the impairment lies in the representation of intended movements. The location of the neural damage associated with these disorders suggests that representations of the current and predicted state of the motor system are in parietal cortex, while representations of intended actions are found in prefrontal and premotor cortex.

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Selected References

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  1. Aglioti S., Bonazzi A., Cortese F. Phantom lower limb as a perceptual marker of neural plasticity in the mature human brain. Proc Biol Sci. 1994 Mar 22;255(1344):273–278. doi: 10.1098/rspb.1994.0039. [DOI] [PubMed] [Google Scholar]
  2. Aglioti S., DeSouza J. F., Goodale M. A. Size-contrast illusions deceive the eye but not the hand. Curr Biol. 1995 Jun 1;5(6):679–685. doi: 10.1016/s0960-9822(95)00133-3. [DOI] [PubMed] [Google Scholar]
  3. Andersen R. A., Snyder L. H., Bradley D. C., Xing J. Multimodal representation of space in the posterior parietal cortex and its use in planning movements. Annu Rev Neurosci. 1997;20:303–330. doi: 10.1146/annurev.neuro.20.1.303. [DOI] [PubMed] [Google Scholar]
  4. Ball T., Schreiber A., Feige B., Wagner M., Lücking C. H., Kristeva-Feige R. The role of higher-order motor areas in voluntary movement as revealed by high-resolution EEG and fMRI. Neuroimage. 1999 Dec;10(6):682–694. doi: 10.1006/nimg.1999.0507. [DOI] [PubMed] [Google Scholar]
  5. Banks G., Short P., Martinez J., Latchaw R., Ratcliff G., Boller F. The alien hand syndrome. Clinical and postmortem findings. Arch Neurol. 1989 Apr;46(4):456–459. doi: 10.1001/archneur.1989.00520400116030. [DOI] [PubMed] [Google Scholar]
  6. Blakemore S. J., Frith C. D., Wolpert D. M. Spatio-temporal prediction modulates the perception of self-produced stimuli. J Cogn Neurosci. 1999 Sep;11(5):551–559. doi: 10.1162/089892999563607. [DOI] [PubMed] [Google Scholar]
  7. Blakemore S. J., Goodbody S. J., Wolpert D. M. Predicting the consequences of our own actions: the role of sensorimotor context estimation. J Neurosci. 1998 Sep 15;18(18):7511–7518. doi: 10.1523/JNEUROSCI.18-18-07511.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Blakemore S. J., Wolpert D. M., Frith C. D. Central cancellation of self-produced tickle sensation. Nat Neurosci. 1998 Nov;1(7):635–640. doi: 10.1038/2870. [DOI] [PubMed] [Google Scholar]
  9. Bridgemen B., Kirch M., Sperling A. Segregation of cognitive and motor aspects of visual function using induced motion. Percept Psychophys. 1981 Apr;29(4):336–342. doi: 10.3758/bf03207342. [DOI] [PubMed] [Google Scholar]
  10. Castiello U., Paulignan Y., Jeannerod M. Temporal dissociation of motor responses and subjective awareness. A study in normal subjects. Brain. 1991 Dec;114(Pt 6):2639–2655. doi: 10.1093/brain/114.6.2639. [DOI] [PubMed] [Google Scholar]
  11. Clower D. M., Hoffman J. M., Votaw J. R., Faber T. L., Woods R. P., Alexander G. E. Role of posterior parietal cortex in the recalibration of visually guided reaching. Nature. 1996 Oct 17;383(6601):618–621. doi: 10.1038/383618a0. [DOI] [PubMed] [Google Scholar]
  12. Colby C. L., Duhamel J. R., Goldberg M. E. Oculocentric spatial representation in parietal cortex. Cereb Cortex. 1995 Sep-Oct;5(5):470–481. doi: 10.1093/cercor/5.5.470. [DOI] [PubMed] [Google Scholar]
  13. Colby C. L., Duhamel J. R. Spatial representations for action in parietal cortex. Brain Res Cogn Brain Res. 1996 Dec;5(1-2):105–115. doi: 10.1016/s0926-6410(96)00046-8. [DOI] [PubMed] [Google Scholar]
  14. Corbetta M. Frontoparietal cortical networks for directing attention and the eye to visual locations: identical, independent, or overlapping neural systems? Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):831–838. doi: 10.1073/pnas.95.3.831. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Corbetta M., Miezin F. M., Shulman G. L., Petersen S. E. A PET study of visuospatial attention. J Neurosci. 1993 Mar;13(3):1202–1226. doi: 10.1523/JNEUROSCI.13-03-01202.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Daprati E., Franck N., Georgieff N., Proust J., Pacherie E., Dalery J., Jeannerod M. Looking for the agent: an investigation into consciousness of action and self-consciousness in schizophrenic patients. Cognition. 1997 Dec;65(1):71–86. doi: 10.1016/s0010-0277(97)00039-5. [DOI] [PubMed] [Google Scholar]
  17. De Renzi E., Faglioni P., Sorgato P. Modality-specific and supramodal mechanisms of apraxia. Brain. 1982 Jun;105(Pt 2):301–312. doi: 10.1093/brain/105.2.301. [DOI] [PubMed] [Google Scholar]
  18. De Renzi E., Lucchelli F. Ideational apraxia. Brain. 1988 Oct;111(Pt 5):1173–1185. doi: 10.1093/brain/111.5.1173. [DOI] [PubMed] [Google Scholar]
  19. Decety J., Jeannerod M., Germain M., Pastene J. Vegetative response during imagined movement is proportional to mental effort. Behav Brain Res. 1991 Jan 31;42(1):1–5. doi: 10.1016/s0166-4328(05)80033-6. [DOI] [PubMed] [Google Scholar]
  20. Decety J., Perani D., Jeannerod M., Bettinardi V., Tadary B., Woods R., Mazziotta J. C., Fazio F. Mapping motor representations with positron emission tomography. Nature. 1994 Oct 13;371(6498):600–602. doi: 10.1038/371600a0. [DOI] [PubMed] [Google Scholar]
  21. Degos J. D., da Fonseca N., Gray F., Cesaro P. Severe frontal syndrome associated with infarcts of the left anterior cingulate gyrus and the head of the right caudate nucleus. A clinico-pathological case. Brain. 1993 Dec;116(Pt 6):1541–1548. doi: 10.1093/brain/116.6.1541. [DOI] [PubMed] [Google Scholar]
  22. Deiber M. P., Passingham R. E., Colebatch J. G., Friston K. J., Nixon P. D., Frackowiak R. S. Cortical areas and the selection of movement: a study with positron emission tomography. Exp Brain Res. 1991;84(2):393–402. doi: 10.1007/BF00231461. [DOI] [PubMed] [Google Scholar]
  23. Dettmers C., Fink G. R., Lemon R. N., Stephan K. M., Passingham R. E., Silbersweig D., Holmes A., Ridding M. C., Brooks D. J., Frackowiak R. S. Relation between cerebral activity and force in the motor areas of the human brain. J Neurophysiol. 1995 Aug;74(2):802–815. doi: 10.1152/jn.1995.74.2.802. [DOI] [PubMed] [Google Scholar]
  24. Duhamel J. R., Colby C. L., Goldberg M. E. The updating of the representation of visual space in parietal cortex by intended eye movements. Science. 1992 Jan 3;255(5040):90–92. doi: 10.1126/science.1553535. [DOI] [PubMed] [Google Scholar]
  25. Fink G. R., Marshall J. C., Halligan P. W., Frith C. D., Driver J., Frackowiak R. S., Dolan R. J. The neural consequences of conflict between intention and the senses. Brain. 1999 Mar;122(Pt 3):497–512. doi: 10.1093/brain/122.3.497. [DOI] [PubMed] [Google Scholar]
  26. Fletcher P., McKenna P. J., Friston K. J., Frith C. D., Dolan R. J. Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. Neuroimage. 1999 Mar;9(3):337–342. doi: 10.1006/nimg.1998.0411. [DOI] [PubMed] [Google Scholar]
  27. Fourneret P., Jeannerod M. Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia. 1998 Nov;36(11):1133–1140. doi: 10.1016/s0028-3932(98)00006-2. [DOI] [PubMed] [Google Scholar]
  28. Frith C. D., Done D. J. Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action. Psychol Med. 1989 May;19(2):359–363. doi: 10.1017/s003329170001240x. [DOI] [PubMed] [Google Scholar]
  29. Frith C. D. The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychol Med. 1987 Aug;17(3):631–648. doi: 10.1017/s0033291700025873. [DOI] [PubMed] [Google Scholar]
  30. Galletti C., Battaglini P. P., Fattori P. Parietal neurons encoding spatial locations in craniotopic coordinates. Exp Brain Res. 1993;96(2):221–229. doi: 10.1007/BF00227102. [DOI] [PubMed] [Google Scholar]
  31. Gentilucci M., Chieffi S., Deprati E., Saetti M. C., Toni I. Visual illusion and action. Neuropsychologia. 1996 May;34(5):369–376. doi: 10.1016/0028-3932(95)00128-x. [DOI] [PubMed] [Google Scholar]
  32. Geschwind N. Disconnexion syndromes in animals and man. I. Brain. 1965 Jun;88(2):237–294. doi: 10.1093/brain/88.2.237. [DOI] [PubMed] [Google Scholar]
  33. Ghahramani Z., Wolpert D. M. Modular decomposition in visuomotor learning. Nature. 1997 Mar 27;386(6623):392–395. doi: 10.1038/386392a0. [DOI] [PubMed] [Google Scholar]
  34. Goldberg G., Mayer N. H., Toglia J. U. Medial frontal cortex infarction and the alien hand sign. Arch Neurol. 1981 Nov;38(11):683–686. doi: 10.1001/archneur.1981.00510110043004. [DOI] [PubMed] [Google Scholar]
  35. Goodale M. A., Pelisson D., Prablanc C. Large adjustments in visually guided reaching do not depend on vision of the hand or perception of target displacement. Nature. 1986 Apr 24;320(6064):748–750. doi: 10.1038/320748a0. [DOI] [PubMed] [Google Scholar]
  36. Greeno J. G. Gibson's affordances. Psychol Rev. 1994 Apr;101(2):336–342. doi: 10.1037/0033-295x.101.2.336. [DOI] [PubMed] [Google Scholar]
  37. Haggard P., Eimer M. On the relation between brain potentials and the awareness of voluntary movements. Exp Brain Res. 1999 May;126(1):128–133. doi: 10.1007/s002210050722. [DOI] [PubMed] [Google Scholar]
  38. Haggard P., Magno E. Localising awareness of action with transcranial magnetic stimulation. Exp Brain Res. 1999 Jul;127(1):102–107. doi: 10.1007/s002210050778. [DOI] [PubMed] [Google Scholar]
  39. Haggard P., Newman C., Magno E. On the perceived time of voluntary actions. Br J Psychol. 1999 May;90(Pt 2):291–303. doi: 10.1348/000712699161413. [DOI] [PubMed] [Google Scholar]
  40. Hari R., Hänninen R., Mäkinen T., Jousmäki V., Forss N., Seppä M., Salonen O. Three hands: fragmentation of human bodily awareness. Neurosci Lett. 1998 Jan 16;240(3):131–134. doi: 10.1016/s0304-3940(97)00945-2. [DOI] [PubMed] [Google Scholar]
  41. Heilman K. M., Barrett A. M., Adair J. C. Possible mechanisms of anosognosia: a defect in self-awareness. Philos Trans R Soc Lond B Biol Sci. 1998 Nov 29;353(1377):1903–1909. doi: 10.1098/rstb.1998.0342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Ito M. Neurophysiological aspects of the cerebellar motor control system. Int J Neurol. 1970;7(2):162–176. [PubMed] [Google Scholar]
  43. Jeannerod M., Arbib M. A., Rizzolatti G., Sakata H. Grasping objects: the cortical mechanisms of visuomotor transformation. Trends Neurosci. 1995 Jul;18(7):314–320. [PubMed] [Google Scholar]
  44. Jeannerod M., Decety J., Michel F. Impairment of grasping movements following a bilateral posterior parietal lesion. Neuropsychologia. 1994 Apr;32(4):369–380. doi: 10.1016/0028-3932(94)90084-1. [DOI] [PubMed] [Google Scholar]
  45. Jeannerod M., Michel F., Prablanc C. The control of hand movements in a case of hemianaesthesia following a parietal lesion. Brain. 1984 Sep;107(Pt 3):899–920. doi: 10.1093/brain/107.3.899. [DOI] [PubMed] [Google Scholar]
  46. Jueptner M., Stephan K. M., Frith C. D., Brooks D. J., Frackowiak R. S., Passingham R. E. Anatomy of motor learning. I. Frontal cortex and attention to action. J Neurophysiol. 1997 Mar;77(3):1313–1324. doi: 10.1152/jn.1997.77.3.1313. [DOI] [PubMed] [Google Scholar]
  47. Kalaska J. F., Crammond D. J. Cerebral cortical mechanisms of reaching movements. Science. 1992 Mar 20;255(5051):1517–1523. doi: 10.1126/science.1549781. [DOI] [PubMed] [Google Scholar]
  48. Kew J. J., Halligan P. W., Marshall J. C., Passingham R. E., Rothwell J. C., Ridding M. C., Marsden C. D., Brooks D. J. Abnormal access of axial vibrotactile input to deafferented somatosensory cortex in human upper limb amputees. J Neurophysiol. 1997 May;77(5):2753–2764. doi: 10.1152/jn.1997.77.5.2753. [DOI] [PubMed] [Google Scholar]
  49. Krams M., Rushworth M. F., Deiber M. P., Frackowiak R. S., Passingham R. E. The preparation, execution and suppression of copied movements in the human brain. Exp Brain Res. 1998 Jun;120(3):386–398. doi: 10.1007/s002210050412. [DOI] [PubMed] [Google Scholar]
  50. Lhermitte F. 'Utilization behaviour' and its relation to lesions of the frontal lobes. Brain. 1983 Jun;106(Pt 2):237–255. doi: 10.1093/brain/106.2.237. [DOI] [PubMed] [Google Scholar]
  51. Lhermitte F. Human autonomy and the frontal lobes. Part II: Patient behavior in complex and social situations: the "environmental dependency syndrome". Ann Neurol. 1986 Apr;19(4):335–343. doi: 10.1002/ana.410190405. [DOI] [PubMed] [Google Scholar]
  52. Libet B., Gleason C. A., Wright E. W., Pearl D. K. Time of conscious intention to act in relation to onset of cerebral activity (readiness-potential). The unconscious initiation of a freely voluntary act. Brain. 1983 Sep;106(Pt 3):623–642. doi: 10.1093/brain/106.3.623. [DOI] [PubMed] [Google Scholar]
  53. Lu M. T., Preston J. B., Strick P. L. Interconnections between the prefrontal cortex and the premotor areas in the frontal lobe. J Comp Neurol. 1994 Mar 15;341(3):375–392. doi: 10.1002/cne.903410308. [DOI] [PubMed] [Google Scholar]
  54. Malenka R. C., Angel R. W., Hampton B., Berger P. A. Impaired central error-correcting behavior in schizophrenia. Arch Gen Psychiatry. 1982 Jan;39(1):101–107. doi: 10.1001/archpsyc.1982.04290010073013. [DOI] [PubMed] [Google Scholar]
  55. McCloskey D. I., Colebatch J. G., Potter E. K., Burke D. Judgements about onset of rapid voluntary movements in man. J Neurophysiol. 1983 Apr;49(4):851–863. doi: 10.1152/jn.1983.49.4.851. [DOI] [PubMed] [Google Scholar]
  56. Miall R. C., Weir D. J., Wolpert D. M., Stein J. F. Is the cerebellum a smith predictor? J Mot Behav. 1993 Sep;25(3):203–216. doi: 10.1080/00222895.1993.9942050. [DOI] [PubMed] [Google Scholar]
  57. Milner A. D., Paulignan Y., Dijkerman H. C., Michel F., Jeannerod M. A paradoxical improvement of misreaching in optic ataxia: new evidence for two separate neural systems for visual localization. Proc Biol Sci. 1999 Nov 7;266(1434):2225–2229. doi: 10.1098/rspb.1999.0912. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Mlakar J., Jensterle J., Frith C. D. Central monitoring deficiency and schizophrenic symptoms. Psychol Med. 1994 Aug;24(3):557–564. doi: 10.1017/s0033291700027719. [DOI] [PubMed] [Google Scholar]
  59. Nobre A. C., Sebestyen G. N., Gitelman D. R., Mesulam M. M., Frackowiak R. S., Frith C. D. Functional localization of the system for visuospatial attention using positron emission tomography. Brain. 1997 Mar;120(Pt 3):515–533. doi: 10.1093/brain/120.3.515. [DOI] [PubMed] [Google Scholar]
  60. Noice H., Noice T. Two approaches to learning a theatrical script. Memory. 1996 Jan;4(1):1–17. doi: 10.1080/741940662. [DOI] [PubMed] [Google Scholar]
  61. Pascual-Leone A., Nguyet D., Cohen L. G., Brasil-Neto J. P., Cammarota A., Hallett M. Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. J Neurophysiol. 1995 Sep;74(3):1037–1045. doi: 10.1152/jn.1995.74.3.1037. [DOI] [PubMed] [Google Scholar]
  62. Paus T., Kalina M., Patocková L., Angerová Y., Cerný R., Mecir P., Bauer J., Krabec P. Medial vs lateral frontal lobe lesions and differential impairment of central-gaze fixation maintenance in man. Brain. 1991 Oct;114(Pt 5):2051–2067. doi: 10.1093/brain/114.5.2051. [DOI] [PubMed] [Google Scholar]
  63. Pause M., Kunesch E., Binkofski F., Freund H. J. Sensorimotor disturbances in patients with lesions of the parietal cortex. Brain. 1989 Dec;112(Pt 6):1599–1625. doi: 10.1093/brain/112.6.1599. [DOI] [PubMed] [Google Scholar]
  64. Perenin M. T., Rossetti Y. Grasping without form discrimination in a hemianopic field. Neuroreport. 1996 Feb 29;7(3):793–797. doi: 10.1097/00001756-199602290-00027. [DOI] [PubMed] [Google Scholar]
  65. Perenin M. T., Vighetto A. Optic ataxia: a specific disruption in visuomotor mechanisms. I. Different aspects of the deficit in reaching for objects. Brain. 1988 Jun;111(Pt 3):643–674. doi: 10.1093/brain/111.3.643. [DOI] [PubMed] [Google Scholar]
  66. Picard N., Strick P. L. Motor areas of the medial wall: a review of their location and functional activation. Cereb Cortex. 1996 May-Jun;6(3):342–353. doi: 10.1093/cercor/6.3.342. [DOI] [PubMed] [Google Scholar]
  67. Ramachandran V. S., Hirstein W. The perception of phantom limbs. The D. O. Hebb lecture. Brain. 1998 Sep;121(Pt 9):1603–1630. doi: 10.1093/brain/121.9.1603. [DOI] [PubMed] [Google Scholar]
  68. Ramachandran V. S., Rogers-Ramachandran D., Stewart M. Perceptual correlates of massive cortical reorganization. Science. 1992 Nov 13;258(5085):1159–1160. doi: 10.1126/science.1439826. [DOI] [PubMed] [Google Scholar]
  69. Ramachandran V. S., Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996 Apr 22;263(1369):377–386. doi: 10.1098/rspb.1996.0058. [DOI] [PubMed] [Google Scholar]
  70. Ramachandran V. S. What neurological syndromes can tell us about human nature: some lessons from phantom limbs, capgras syndrome, and anosognosia. Cold Spring Harb Symp Quant Biol. 1996;61:115–134. [PubMed] [Google Scholar]
  71. Rizzolatti G., Fogassi L., Gallese V. Parietal cortex: from sight to action. Curr Opin Neurobiol. 1997 Aug;7(4):562–567. doi: 10.1016/s0959-4388(97)80037-2. [DOI] [PubMed] [Google Scholar]
  72. Rizzolatti G., Riggio L., Dascola I., Umiltá C. Reorienting attention across the horizontal and vertical meridians: evidence in favor of a premotor theory of attention. Neuropsychologia. 1987;25(1A):31–40. doi: 10.1016/0028-3932(87)90041-8. [DOI] [PubMed] [Google Scholar]
  73. Rossetti Y. Implicit short-lived motor representations of space in brain damaged and healthy subjects. Conscious Cogn. 1998 Sep;7(3):520–558. doi: 10.1006/ccog.1998.0370. [DOI] [PubMed] [Google Scholar]
  74. Rothwell J. C., Traub M. M., Day B. L., Obeso J. A., Thomas P. K., Marsden C. D. Manual motor performance in a deafferented man. Brain. 1982 Sep;105(Pt 3):515–542. doi: 10.1093/brain/105.3.515. [DOI] [PubMed] [Google Scholar]
  75. Rushworth M. F., Nixon P. D., Passingham R. E. Parietal cortex and movement. I. Movement selection and reaching. Exp Brain Res. 1997 Nov;117(2):292–310. doi: 10.1007/s002210050224. [DOI] [PubMed] [Google Scholar]
  76. SPERRY R. W. Neural basis of the spontaneous optokinetic response produced by visual inversion. J Comp Physiol Psychol. 1950 Dec;43(6):482–489. doi: 10.1037/h0055479. [DOI] [PubMed] [Google Scholar]
  77. Sirigu A., Daprati E., Pradat-Diehl P., Franck N., Jeannerod M. Perception of self-generated movement following left parietal lesion. Brain. 1999 Oct;122(Pt 10):1867–1874. doi: 10.1093/brain/122.10.1867. [DOI] [PubMed] [Google Scholar]
  78. Sirigu A., Duhamel J. R., Cohen L., Pillon B., Dubois B., Agid Y. The mental representation of hand movements after parietal cortex damage. Science. 1996 Sep 13;273(5281):1564–1568. doi: 10.1126/science.273.5281.1564. [DOI] [PubMed] [Google Scholar]
  79. Spence S. A., Brooks D. J., Hirsch S. R., Liddle P. F., Meehan J., Grasby P. M. A PET study of voluntary movement in schizophrenic patients experiencing passivity phenomena (delusions of alien control). Brain. 1997 Nov;120(Pt 11):1997–2011. doi: 10.1093/brain/120.11.1997. [DOI] [PubMed] [Google Scholar]
  80. Stephan K. M., Fink G. R., Passingham R. E., Silbersweig D., Ceballos-Baumann A. O., Frith C. D., Frackowiak R. S. Functional anatomy of the mental representation of upper extremity movements in healthy subjects. J Neurophysiol. 1995 Jan;73(1):373–386. doi: 10.1152/jn.1995.73.1.373. [DOI] [PubMed] [Google Scholar]
  81. Stirling J. D., Hellewell J. S., Quraishi N. Self-monitoring dysfunction and the schizophrenic symptoms of alien control. Psychol Med. 1998 May;28(3):675–683. doi: 10.1017/s0033291798006679. [DOI] [PubMed] [Google Scholar]
  82. Vallar G., Perani D. The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia. 1986;24(5):609–622. doi: 10.1016/0028-3932(86)90001-1. [DOI] [PubMed] [Google Scholar]
  83. Vetter P., Goodbody S. J., Wolpert D. M. Evidence for an eye-centered spherical representation of the visuomotor map. J Neurophysiol. 1999 Feb;81(2):935–939. doi: 10.1152/jn.1999.81.2.935. [DOI] [PubMed] [Google Scholar]
  84. Vogt S. On relations between perceiving, imagining and performing in the learning of cyclical movement sequences. Br J Psychol. 1995 May;86(Pt 2):191–216. doi: 10.1111/j.2044-8295.1995.tb02556.x. [DOI] [PubMed] [Google Scholar]
  85. Vuilleumier P., Reverdin A., Landis T. Four legs. Illusory reduplication of the lower limbs after bilateral parietal lobe damage. Arch Neurol. 1997 Dec;54(12):1543–1547. doi: 10.1001/archneur.1997.00550240091017. [DOI] [PubMed] [Google Scholar]
  86. Wegner D. M., Wheatley T. Apparent mental causation. Sources of the experience of will. Am Psychol. 1999 Jul;54(7):480–492. doi: 10.1037//0003-066x.54.7.480. [DOI] [PubMed] [Google Scholar]
  87. Weiller C., Jüptner M., Fellows S., Rijntjes M., Leonhardt G., Kiebel S., Müller S., Diener H. C., Thilmann A. F. Brain representation of active and passive movements. Neuroimage. 1996 Oct;4(2):105–110. doi: 10.1006/nimg.1996.0034. [DOI] [PubMed] [Google Scholar]
  88. Weiskrantz L., Elliott J., Darlington C. Preliminary observations on tickling oneself. Nature. 1971 Apr 30;230(5296):598–599. doi: 10.1038/230598a0. [DOI] [PubMed] [Google Scholar]
  89. Wolpert D. M., Ghahramani Z., Jordan M. I. An internal model for sensorimotor integration. Science. 1995 Sep 29;269(5232):1880–1882. doi: 10.1126/science.7569931. [DOI] [PubMed] [Google Scholar]
  90. Wolpert D. M., Goodbody S. J., Husain M. Maintaining internal representations: the role of the human superior parietal lobe. Nat Neurosci. 1998 Oct;1(6):529–533. doi: 10.1038/2245. [DOI] [PubMed] [Google Scholar]
  91. Wolpert D. M., Kawato M. Multiple paired forward and inverse models for motor control. Neural Netw. 1998 Oct;11(7-8):1317–1329. doi: 10.1016/s0893-6080(98)00066-5. [DOI] [PubMed] [Google Scholar]
  92. Wolpert D. M., Miall R. C. Forward Models for Physiological Motor Control. Neural Netw. 1996 Nov;9(8):1265–1279. doi: 10.1016/s0893-6080(96)00035-4. [DOI] [PubMed] [Google Scholar]
  93. Yue G., Cole K. J. Strength increases from the motor program: comparison of training with maximal voluntary and imagined muscle contractions. J Neurophysiol. 1992 May;67(5):1114–1123. doi: 10.1152/jn.1992.67.5.1114. [DOI] [PubMed] [Google Scholar]

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