Abstract
This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen's laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule cells in the hippocampus of anaesthetized rabbits, I observed that brief trains of stimuli resulted in increased efficiency of transmission at the perforant path-granule cell synapses that could last for hours. In 1968, Tim Bliss came to Per Andersen's laboratory to learn about the hippocampus and field potential recording for studies of possible memory mechanisms. The two of us then followed up my preliminary results from 1966 and did the experiments that resulted in a paper that is now properly considered to be the basic reference for the discovery of LTP.
Full Text
The Full Text of this article is available as a PDF (97.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersen P., Holmqvist B., Voorhoeve P. E. Entorhinal activation of dentate granule cells. Acta Physiol Scand. 1966 Apr;66(4):448–460. doi: 10.1111/j.1748-1716.1966.tb03223.x. [DOI] [PubMed] [Google Scholar]
- Andersen P., Lomo T. Control of hippocampal output by afferent volley frequency. Prog Brain Res. 1967;27:400–412. doi: 10.1016/S0079-6123(08)63112-X. [DOI] [PubMed] [Google Scholar]
- Bezakova G., Lømo T. Muscle activity and muscle agrin regulate the organization of cytoskeletal proteins and attached acetylcholine receptor (AchR) aggregates in skeletal muscle fibers. J Cell Biol. 2001 Jun 25;153(7):1453–1463. doi: 10.1083/jcb.153.7.1453. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bliss T. V., Burns B. D., Uttley A. M. Factors affecting the conductivity of pathways in the cerebral cortex. J Physiol. 1968 Mar;195(2):339–367. doi: 10.1113/jphysiol.1968.sp008462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bliss T. V., Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol. 1973 Jul;232(2):331–356. doi: 10.1113/jphysiol.1973.sp010273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GLOOR P., VERA C. L., SPERTI L. ELECTROPHYSIOLOGICAL STUDIES OF HIPPOCAMPAL NEURONS. 3. RESPONSES OF HIPPOCAMPAL NEURONS TO REPETITIVE PERFORANT PATH VOLLEYS. Electroencephalogr Clin Neurophysiol. 1964 Oct;17:353–370. doi: 10.1016/0013-4694(64)90158-0. [DOI] [PubMed] [Google Scholar]
- GREEN J. D., ADEY W. R. Electrophysiological studies of hippocampal connections and excitability. Electroencephalogr Clin Neurophysiol. 1956 May;8(2):245–263. doi: 10.1016/0013-4694(56)90117-1. [DOI] [PubMed] [Google Scholar]
- Kandel E. R., Spencer W. A. Cellular neurophysiological approaches in the study of learning. Physiol Rev. 1968 Jan;48(1):65–134. doi: 10.1152/physrev.1968.48.1.65. [DOI] [PubMed] [Google Scholar]
- Lomo T. Patterns of activation in a monosynaptic cortical pathway: the perforant path input to the dentate area of the hippocampal formation. Exp Brain Res. 1971;12(1):18–45. [PubMed] [Google Scholar]
- Lomo T. Potentiation of monosynaptic EPSPs in the perforant path-dentate granule cell synapse. Exp Brain Res. 1971;12(1):46–63. [PubMed] [Google Scholar]
- Lomo T., Rosenthal J. Control of ACh sensitivity by muscle activity in the rat. J Physiol. 1972 Mar;221(2):493–513. doi: 10.1113/jphysiol.1972.sp009764. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lomo T., Westgaard R. H., Dahl H. A. Contractile properties of muscle: control by pattern of muscle activity in the rat. Proc R Soc Lond B Biol Sci. 1974 Aug 27;187(1086):99–103. doi: 10.1098/rspb.1974.0064. [DOI] [PubMed] [Google Scholar]