Abstract
In the mid-1960s, it was generally agreed that the engram, the neural trace of previously experienced events, must be encoded by Hebb-like neurons in which synaptic efficacy could be modified by activity. Here, I describe my attempts as a PhD student at McGill University, Montreal, to find rules governing cortical plasticity in the neocortex, and having failed, why the hippocampus seemed to offer a far better prospect.
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Selected References
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- Bliss T. V., Burns B. D., Uttley A. M. Factors affecting the conductivity of pathways in the cerebral cortex. J Physiol. 1968 Mar;195(2):339–367. doi: 10.1113/jphysiol.1968.sp008462. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bliss T. V., Gardner-Medwin A. R. Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path. J Physiol. 1973 Jul;232(2):357–374. doi: 10.1113/jphysiol.1973.sp010274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bliss T. V., Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol. 1973 Jul;232(2):331–356. doi: 10.1113/jphysiol.1973.sp010273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ECCLES J. C., McINTYRE A. K. The effects of disuse and of activity on mammalian spinal reflexes. J Physiol. 1953 Sep;121(3):492–516. doi: 10.1113/jphysiol.1953.sp004961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAMLYN L. H. An electron microscope study of pyramidal neurons in the Ammon's horn of the rabbit. J Anat. 1963 Apr;97:189–201. [PMC free article] [PubMed] [Google Scholar]
- Kandel E. R., Tauc L. Heterosynaptic facilitation in neurones of the abdominal ganglion of Aplysia depilans. J Physiol. 1965 Nov;181(1):1–27. doi: 10.1113/jphysiol.1965.sp007742. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LLOYD D. P. C. Post-tetanic potentiation of response in monosynaptic reflex pathways of the spinal cord. J Gen Physiol. 1949 Nov;33(2):147–170. doi: 10.1085/jgp.33.2.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCOVILLE W. B., MILNER B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11–21. doi: 10.1136/jnnp.20.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]