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Philosophical Transactions of the Royal Society B: Biological Sciences logoLink to Philosophical Transactions of the Royal Society B: Biological Sciences
. 2003 Apr 29;358(1432):629–634. doi: 10.1098/rstb.2002.1231

Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history.

Bruce L McNaughton 1
PMCID: PMC1693161  PMID: 12740107

Abstract

The early history of the experimental work leading to the discovery that long-term potentiation (LTP) embodies Hebb's principle of association is described. In addition, the fallacy underlying the sometimes presumed distinction between 'cooperativity' and 'associativity' in the induction of LTP is pointed out.

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Selected References

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  1. Collingridge G. L., Kehl S. J., McLennan H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol. 1983 Jan;334:33–46. doi: 10.1113/jphysiol.1983.sp014478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Douglas R. M., Goddard G. V. Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus. Brain Res. 1975 Mar 21;86(2):205–215. doi: 10.1016/0006-8993(75)90697-6. [DOI] [PubMed] [Google Scholar]
  3. Douglas R. M., Goddard G. V., Riives M. Inhibitory modulation of long-term potentiation: evidence for a postsynaptic locus of control. Brain Res. 1982 May 27;240(2):259–272. doi: 10.1016/0006-8993(82)90221-9. [DOI] [PubMed] [Google Scholar]
  4. Goddard G. V. Development of epileptic seizures through brain stimulation at low intensity. Nature. 1967 Jun 3;214(5092):1020–1021. doi: 10.1038/2141020a0. [DOI] [PubMed] [Google Scholar]
  5. Goddard G. V., McIntyre D. C., Leech C. K. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol. 1969 Nov;25(3):295–330. doi: 10.1016/0014-4886(69)90128-9. [DOI] [PubMed] [Google Scholar]
  6. Harris E. W., Ganong A. H., Cotman C. W. Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res. 1984 Dec 3;323(1):132–137. doi: 10.1016/0006-8993(84)90275-0. [DOI] [PubMed] [Google Scholar]
  7. Hjorth-Simonsen A. Projection of the lateral part of the entorhinal area to the hippocampus and fascia dentata. J Comp Neurol. 1972 Oct;146(2):219–232. doi: 10.1002/cne.901460206. [DOI] [PubMed] [Google Scholar]
  8. MILNER P. M. The cell assembly: Mark II. Psychol Rev. 1957 Jul;64(4):242–252. doi: 10.1037/h0042287. [DOI] [PubMed] [Google Scholar]
  9. Magleby K. L., Zengel J. E. A quantitative description of tetanic and post-tetanic potentiation of transmitter release at the frog neuromuscular junction. J Physiol. 1975 Feb;245(1):183–208. doi: 10.1113/jphysiol.1975.sp010840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Magleby K. L., Zengel J. E. Augmentation: A process that acts to increase transmitter release at the frog neuromuscular junction. J Physiol. 1976 May;257(2):449–470. doi: 10.1113/jphysiol.1976.sp011378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Marr D. A theory for cerebral neocortex. Proc R Soc Lond B Biol Sci. 1970 Nov 3;176(1043):161–234. doi: 10.1098/rspb.1970.0040. [DOI] [PubMed] [Google Scholar]
  12. Marr D. A theory of cerebellar cortex. J Physiol. 1969 Jun;202(2):437–470. doi: 10.1113/jphysiol.1969.sp008820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marr D. Simple memory: a theory for archicortex. Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23–81. doi: 10.1098/rstb.1971.0078. [DOI] [PubMed] [Google Scholar]
  14. McNaughton B. L., Barnes C. A. Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat. J Comp Neurol. 1977 Oct 15;175(4):439–454. doi: 10.1002/cne.901750404. [DOI] [PubMed] [Google Scholar]
  15. McNaughton B. L., Douglas R. M., Goddard G. V. Synaptic enhancement in fascia dentata: cooperativity among coactive afferents. Brain Res. 1978 Nov 24;157(2):277–293. doi: 10.1016/0006-8993(78)90030-6. [DOI] [PubMed] [Google Scholar]
  16. McNaughton B. L. Long-term synaptic enhancement and short-term potentiation in rat fascia dentata act through different mechanisms. J Physiol. 1982 Mar;324:249–262. doi: 10.1113/jphysiol.1982.sp014110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Steward O. Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat. J Comp Neurol. 1976 Jun 1;167(3):285–314. doi: 10.1002/cne.901670303. [DOI] [PubMed] [Google Scholar]
  18. Willshaw D. J., Buckingham J. T. An assessment of Marr's theory of the hippocampus as a temporary memory store. Philos Trans R Soc Lond B Biol Sci. 1990 Aug 29;329(1253):205–215. doi: 10.1098/rstb.1990.0165. [DOI] [PubMed] [Google Scholar]

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