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. 1993 Sep;83(9):1277–1283. doi: 10.2105/ajph.83.9.1277

Smoking, alcohol consumption, and susceptibility to the common cold.

S Cohen 1, D A Tyrrell 1, M A Russell 1, M J Jarvis 1, A P Smith 1
PMCID: PMC1694990  PMID: 8363004

Abstract

OBJECTIVES. This study was conducted to test the supposition that both smoking and consuming alcohol suppress host resistance to viral infections. METHODS. The relations between smoking, alcohol consumption, and the incidence of documented clinical colds were prospectively studied among 391 subjects intentionally exposed to one of five respiratory viruses and 26 subjects given saline. Clinical colds were defined as clinical symptoms verified by the isolation of virus or by an increase in virus-specific antibody titer. Analyses included control variables for demographics; body weight; virus; and environmental, immunological and psychological factors. RESULTS. Smokers were at greater risk for developing colds than nonsmokers because smokers were more likely both to develop infections and to develop illness following infection. Greater numbers of alcoholic drinks (up to three or four per day) were associated with decreased risk for developing colds because drinking was associated with decreased illness following infection. However, the benefits of drinking occurred only among nonsmokers. CONCLUSIONS. Susceptibility to colds was increased by smoking. Although alcohol consumption did not influence risk of clinical illness for smokers, moderate alcohol consumption was associated with decreased risk for nonsmokers.

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Selected References

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  1. AUSTRIAN R., GOLD J. PNEUMOCOCCAL BACTEREMIA WITH ESPECIAL REFERENCE TO BACTEREMIC PNEUMOCOCCAL PNEUMONIA. Ann Intern Med. 1964 May;60:759–776. doi: 10.7326/0003-4819-60-5-759. [DOI] [PubMed] [Google Scholar]
  2. Adams H. G., Jordan C. Infections in the alcoholic. Med Clin North Am. 1984 Jan;68(1):179–200. doi: 10.1016/s0025-7125(16)31249-4. [DOI] [PubMed] [Google Scholar]
  3. Atkinson J. P., Sullivan T. J., Kelly J. P., Parker C. W. Stimulation by alcohols of cyclic AMP metabolism in human leukocytes. Possible role of cyclic AMP in the anti-inflammatory effects of ethanol. J Clin Invest. 1977 Aug;60(2):284–294. doi: 10.1172/JCI108776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barclay W. S., Al-Nakib W. An ELISA for the detection of rhinovirus specific antibody in serum and nasal secretion. J Virol Methods. 1987 Jan;15(1):53–64. doi: 10.1016/0166-0934(87)90048-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bourne H. R., Lichtenstein L. M., Melmon K. L., Henney C. S., Weinstein Y., Shearer G. M. Modulation of inflammation and immunity by cyclic AMP. Science. 1974 Apr 5;184(4132):19–28. doi: 10.1126/science.184.4132.19. [DOI] [PubMed] [Google Scholar]
  6. Callow K. A. Effect of specific humoral immunity and some non-specific factors on resistance of volunteers to respiratory coronavirus infection. J Hyg (Lond) 1985 Aug;95(1):173–189. doi: 10.1017/s0022172400062410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chan-Yeung M., Ferreira P., Frohlich J., Schulzer M., Tan F. The effects of age, smoking, and alcohol on routine laboratory tests. Am J Clin Pathol. 1981 Mar;75(3):320–326. doi: 10.1093/ajcp/75.3.320. [DOI] [PubMed] [Google Scholar]
  8. Cohen S., Tyrrell D. A., Smith A. P. Psychological stress and susceptibility to the common cold. N Engl J Med. 1991 Aug 29;325(9):606–612. doi: 10.1056/NEJM199108293250903. [DOI] [PubMed] [Google Scholar]
  9. Feyerabend C., Russell M. A. A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluids. J Pharm Pharmacol. 1990 Jun;42(6):450–452. doi: 10.1111/j.2042-7158.1990.tb06592.x. [DOI] [PubMed] [Google Scholar]
  10. Finklea J. F., Sandifer S. H., Smith D. D. Cigarette smoking and epidemic influenza. Am J Epidemiol. 1969 Nov;90(5):390–399. doi: 10.1093/oxfordjournals.aje.a121084. [DOI] [PubMed] [Google Scholar]
  11. Friedman G. D., Siegelaub A. B., Seltzer C. C., Feldman R., Collen M. F. Smoking habits and the leukocyte count. Arch Environ Health. 1973 Mar;26(3):137–143. doi: 10.1080/00039896.1973.10666241. [DOI] [PubMed] [Google Scholar]
  12. Gerrard J. W., Heiner D. C., Ko C. G., Mink J., Meyers A., Dosman J. A. Immunoglobulin levels in smokers and non-smokers. Ann Allergy. 1980 May;44(5):261–262. [PubMed] [Google Scholar]
  13. Gwaltney J. M., Jr, Hendley J. O., Simon G., Jordan W. S., Jr Rhinovirus infections in an industrial population. I. The occurrence of illness. N Engl J Med. 1966 Dec 8;275(23):1261–1268. doi: 10.1056/NEJM196612082752301. [DOI] [PubMed] [Google Scholar]
  14. LaPorte R. E., Cresanta J. L., Kuller L. H. The relationship of alcohol consumption to atherosclerotic heart disease. Prev Med. 1980 Jan;9(1):22–40. doi: 10.1016/0091-7435(80)90057-2. [DOI] [PubMed] [Google Scholar]
  15. MacGregor R. R. Alcohol and immune defense. JAMA. 1986 Sep 19;256(11):1474–1479. [PubMed] [Google Scholar]
  16. MacKenzie J. S., MacKenzie I. H., Holt P. G. The effect of cigarette smoking on susceptibility to epidemic influenza and on serological responses to live attenuated and killed subunit influenza vaccines. J Hyg (Lond) 1976 Dec;77(3):409–417. doi: 10.1017/s0022172400055790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Straus B., Berenyi M. R. Infection and immunity in alcoholic cirrhosis. Mt Sinai J Med. 1973 Sep-Oct;40(5):631–640. [PubMed] [Google Scholar]
  18. Tollerud D. J., Clark J. W., Brown L. M., Neuland C. Y., Mann D. L., Pankiw-Trost L. K., Blattner W. A., Hoover R. N. The effects of cigarette smoking on T cell subsets. A population-based survey of healthy caucasians. Am Rev Respir Dis. 1989 Jun;139(6):1446–1451. doi: 10.1164/ajrccm/139.6.1446. [DOI] [PubMed] [Google Scholar]
  19. Waldman R. H., Bond J. O., Levitt L. P., Hartwig E. C., Prather E. C., Baratta R. L., Neill J. S., Small P. A., Jr An evaluation of influenza immunization: influence of route of administration and vaccine strain. Bull World Health Organ. 1969;41(3):543–548. [PMC free article] [PubMed] [Google Scholar]

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