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. 1970 Jan 10;1(5688):86–89. doi: 10.1136/bmj.1.5688.86

Suppression of Erythropoiesis by Alcohol

D O'B Hourihane, D G Weir
PMCID: PMC1699174  PMID: 5411451

Abstract

Serial measurements in alcoholic subjects showed a profound fall of serum iron for three days after withdrawal of alcohol and a reversion of abnormal accumulation of erythroblastic haemosiderin to normal. These findings suggest an interference in normal haem synthesis, most probably by a direct effect.

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Selected References

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  1. Dacie J. V., Mollin D. L. Siderocytes, sideroblasts and sideroblastic anaemia. Acta Med Scand Suppl. 1966;445:237–248. doi: 10.1111/j.0954-6820.1966.tb02366.x. [DOI] [PubMed] [Google Scholar]
  2. Gitlin N. Zieve's syndrome and porphyrinuria in an alcoholic. Br Med J. 1969 Jan 11;1(5636):96–98. doi: 10.1136/bmj.1.5636.96. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HAWKINS C. F. Value of serum iron levels in assessing effect of haematinics in the macrocytic anaemias. Br Med J. 1955 Feb 12;1(4910):383–385. doi: 10.1136/bmj.1.4910.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HORRIGAN D. L., HARRIS J. W. PYRIDOXINE-RESPONSIVE ANEMIA: ANALYSIS OF 62 CASES. Adv Intern Med. 1964;12:103–174. [PubMed] [Google Scholar]
  5. Hilal H., McCurdy P. R. A pitfall in the interpretation of serum iron values. Ann Intern Med. 1967 May;66(5):983–988. doi: 10.7326/0003-4819-66-5-983. [DOI] [PubMed] [Google Scholar]
  6. JANDL J. H. The anemia of liver disease: observations on its mechanism. J Clin Invest. 1955 Mar;34(3):390–404. doi: 10.1172/JCI103087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KIMBER C., DELLER D. J., IBBOTSON R. N., LANDER H. THE MECHANISM OF ANAEMIA IN CHRONIC LIVER DISEASE. Q J Med. 1965 Jan;34:33–64. [PubMed] [Google Scholar]
  8. Lieber C. S., Rubin E. Alcoholic fatty liver in man on a high protein and low fat diet. Am J Med. 1968 Feb;44(2):200–206. doi: 10.1016/0002-9343(68)90151-4. [DOI] [PubMed] [Google Scholar]
  9. Lindenbaum J., Hargrove R. L. Thrombocytopenia in alcoholics. Ann Intern Med. 1968 Mar;68(3):526–532. doi: 10.7326/0003-4819-68-3-526. [DOI] [PubMed] [Google Scholar]
  10. Lindenbaum J., Lieber C. S. Hematologic effects of alcohol in man in the absence of nutritional deficiency. N Engl J Med. 1969 Aug 14;281(7):333–338. doi: 10.1056/NEJM196908142810701. [DOI] [PubMed] [Google Scholar]
  11. MACDONALD R. A. WINE AS SOURCE OF IRON IN HAEMOCHROMATOSIS. Nature. 1963 Aug 31;199:922–922. doi: 10.1038/199922a0. [DOI] [PubMed] [Google Scholar]
  12. MCFARLAND W., LIBRE E. P. ABNORMAL LEUKOCYTE RESPONSE IN ALCOHOLISM. Ann Intern Med. 1963 Dec;59:865–877. doi: 10.7326/0003-4819-59-6-865. [DOI] [PubMed] [Google Scholar]
  13. PETERS T., GIOVANNIELLO T. J., APT L., ROSS J. F. A new method for the determination of serum iron-binding capacity. I. J Lab Clin Med. 1956 Aug;48(2):274–279. [PubMed] [Google Scholar]
  14. Post R. M., Desforges J. F. Thrombocytopenia and alcoholism. Ann Intern Med. 1968 Jun;68(6):1230–1236. doi: 10.7326/0003-4819-68-6-1230. [DOI] [PubMed] [Google Scholar]
  15. RUBIN D., WEISBERGER A. S., BOTTI R. E., STORAASLI J. P. Changes in iron metabolism in early chloramphenicol toxicity. J Clin Invest. 1958 Sep;37(9):1286–1292. doi: 10.1172/JCI103716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rubin E., Lieber C. S. Alcohol, other drugs, and the liver. Ann Intern Med. 1968 Nov;69(5):1063–1067. doi: 10.7326/0003-4819-69-5-1063. [DOI] [PubMed] [Google Scholar]
  17. SAIDI P., WALLERSTEIN R. O., AGGELER P. M. Effect of chloramphenicol on erythropoiesis. J Lab Clin Med. 1961 Feb;57:247–256. [PubMed] [Google Scholar]
  18. SULLIVAN L. W., HERBERT V. SUPPRESSION HEMATOPOIESIS BY ETHANOL. J Clin Invest. 1964 Nov;43:2048–2062. doi: 10.1172/JCI105079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Temperley I. J., Horner N. Effect of ascorbic acid on the serum folic acid estimation. J Clin Pathol. 1966 Jan;19(1):43–45. doi: 10.1136/jcp.19.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Waters A. H., Morley A. A., Rankin J. G. Effect of alcohol on haemopoiesis. Br Med J. 1966 Dec 24;2(5529):1565–1568. doi: 10.1136/bmj.2.5529.1565. [DOI] [PMC free article] [PubMed] [Google Scholar]

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