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. 1970 Jan 31;1(5691):259–261. doi: 10.1136/bmj.1.5691.259

Australia Antigen in Chronic Hepatitis in Australia*

J D Mathews, I R Mackay
PMCID: PMC1699349  PMID: 5461278

Abstract

Of 53 cases of active chronic liver disease two were found to be carriers of Australia antigen Au (1)—an elderly woman with typical lupoid hepatitis and an elderly mortuary attendant with serologically atypical active chronic hepatitis. Au (1) was detected also in the serum of 7 out of 20 patients with clinically atypical acute hepatitis—one was an elderly Italian woman, one had hepatitis in the puerperium, and five had a history of transfusion or inoculation. The antigen was not found in 20 typical cases of infectious hepatitis in young people in 86 patients with other diseases. Antibody to Au (1) was present in only 2 out of 102 patients who had received numerous transfusions.

We conclude, firstly, that Au (1) antigen is rare in white Australians (in keeping with the low incidence of serum hepatitis in Australia), and, secondly, that Au (1) positivity in hepatitis patients is associated with transfusions and with older age. We suggest that active chronic hepatitis and lupoid hepatitis may follow infection of susceptible individuals with Au (1)-positive hepatitis virus, but persistence of the virus in high titre does not appear to be necessary for chronicity of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLUMBERG B. S., ALTER H. J., VISNICH S. A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA. 1965 Feb 15;191:541–546. doi: 10.1001/jama.1965.03080070025007. [DOI] [PubMed] [Google Scholar]
  2. Bayer M. E., Blumberg B. S., Werner B. Particles associated with Australia antigen in the sera of patients with leukaemia, Down's Syndrome and hepatitis. Nature. 1968 Jun 15;218(5146):1057–1059. doi: 10.1038/2181057a0. [DOI] [PubMed] [Google Scholar]
  3. Blumberg B. S., Gerstley B. J., Hungerford D. A., London W. T., Sutnick A. I. A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann Intern Med. 1967 May;66(5):924–931. doi: 10.7326/0003-4819-66-5-924. [DOI] [PubMed] [Google Scholar]
  4. Blumberg B. S., Sutnick A. I., London W. T. Hepatitis and leukemia: their relation to Australia antigen. Bull N Y Acad Med. 1968 Dec;44(12):1566–1586. [PMC free article] [PubMed] [Google Scholar]
  5. Cossart Y. E. Hepatitis antigen. Lancet. 1969 Jun 14;1(7607):1216–1216. doi: 10.1016/s0140-6736(69)92205-3. [DOI] [PubMed] [Google Scholar]
  6. Fox R. A., Niazi S. P., Sherlock S. Hepatitis-associated antigen in chronic liver disease. Lancet. 1969 Sep 20;2(7621):609–612. doi: 10.1016/s0140-6736(69)90324-9. [DOI] [PubMed] [Google Scholar]
  7. Giles J. P., McCollum R. W., Berndtson L. W., Jr, Krugman S. Relation of Australia-SH antigen to the willowbrook MS-2 strain. N Engl J Med. 1969 Jul 17;281(3):119–122. doi: 10.1056/NEJM196907172810302. [DOI] [PubMed] [Google Scholar]
  8. Gitnick G. L., Gleich G. J., Schoenfield L. J., Baggenstoss A. H., Sutnick A. I., Blumberg B. S., London W. T., Summerskill W. H. Australia antigen in chronic active liver disease with cirrhosis. Lancet. 1969 Aug 9;2(7615):285–288. doi: 10.1016/s0140-6736(69)90052-x. [DOI] [PubMed] [Google Scholar]
  9. Gocke D. J., Kavey N. B. Hepatitis antigen. Correlation with disease and infectivity of blood-donors. Lancet. 1969 May 31;1(7605):1055–1059. doi: 10.1016/s0140-6736(69)91701-2. [DOI] [PubMed] [Google Scholar]
  10. Hirschman R. J., Shulman N. R., Barker L. F., Smith K. O. Virus-like particles in sera of patients with infectious and serum hepatitis. JAMA. 1969 Jun 2;208(9):1667–1670. [PubMed] [Google Scholar]
  11. Krugman S., Giles J. P., Hammond J. Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967 May 1;200(5):365–373. doi: 10.1001/jama.200.5.365. [DOI] [PubMed] [Google Scholar]
  12. London W. T., Sutnick A. I., Blumberg B. S. Australia antigen and acute viral hepatitis. Ann Intern Med. 1969 Jan;70(1):55–59. doi: 10.7326/0003-4819-70-1-55. [DOI] [PubMed] [Google Scholar]
  13. MACKAY I. R., WOOD I. J. THE COURSE AND TREATMENT OF LUPOID HEPATITIS. Gastroenterology. 1963 Jul;45:4–13. [PubMed] [Google Scholar]
  14. Mackay I. R., Weiden S., Hasker J. Autoimmune hepatitis. Ann N Y Acad Sci. 1965 Jun 30;124(2):767–780. doi: 10.1111/j.1749-6632.1965.tb19000.x. [DOI] [PubMed] [Google Scholar]
  15. Okochi K., Murakami S. Observations on Australia antigen in Japanese. Vox Sang. 1968;15(5):374–385. doi: 10.1111/j.1423-0410.1968.tb04078.x. [DOI] [PubMed] [Google Scholar]
  16. Prince A. M. An antigen detected in the blood during the incubation period of serum hepatitis. Proc Natl Acad Sci U S A. 1968 Jul;60(3):814–821. doi: 10.1073/pnas.60.3.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Prince A. M. Relation of Australia and SH antigens. Lancet. 1968 Aug 24;2(7565):462–463. doi: 10.1016/s0140-6736(68)90512-6. [DOI] [PubMed] [Google Scholar]
  18. Turner G. C., White G. B. S.H. antigen in haemodialysis-associated hepatitis. Lancet. 1969 Jul 19;2(7612):121–124. [PubMed] [Google Scholar]
  19. Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]

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