Abstract
In 20 patients with idiopathic Parkinsonism maximum tolerated doses of L-dopa were found to induce a mean reduction in blood pressure (erect systolic) of 19·3 mm.Hg, without any significant change in pulse rate. This hypotension may be due to dopamine, acting on adrenergic nerve endings or on the central nervous system itself.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURN J. H., RAND M. J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. doi: 10.1113/jphysiol.1958.sp006104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barbeau A., Gillo-Joffroy L., Boucher R., Nowaczynski W., Genest J. Renin-aldosterone system in Parkinson's disease. Science. 1969 Jul 18;165(3890):291–292. doi: 10.1126/science.165.3890.291. [DOI] [PubMed] [Google Scholar]
- Calne D. B., Stern G. M., Laurence D. R., Sharkey J., Armitage P. L-dopa in postencephalitic parkinsonism. Lancet. 1969 Apr 12;1(7598):744–746. doi: 10.1016/s0140-6736(69)91751-6. [DOI] [PubMed] [Google Scholar]
- Collins G. G., West G. B. The release of 3H-dopamine from the isolated rabbit ileum. Br J Pharmacol. 1968 Nov;34(3):514–522. doi: 10.1111/j.1476-5381.1968.tb08480.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cotzias G. C., Papavasiliou P. S., Gellene R., Aronson R. B. Parkinsonism and DOPA. Trans Assoc Am Physicians. 1968;81:171–183. [PubMed] [Google Scholar]
- GOLDBERG L. I., SJOERDSMA A. Effects of several monoamine oxidase inhibitors on the cardiovascular actions of naturally occurring amines in the dog. J Pharmacol Exp Ther. 1959 Nov;127:212–218. [PubMed] [Google Scholar]
- Goldberg L. I., Talley R. C., McNay J. L. The potential role of dopamine in the treatment of shock. Prog Cardiovasc Dis. 1969 Jul;12(1):40–51. doi: 10.1016/0033-0620(69)90034-6. [DOI] [PubMed] [Google Scholar]
- Goodwin F. K., Murphy D. L., Bunney W. E., Jr Lithium. Lancet. 1969 Jul 26;2(7613):212–213. doi: 10.1016/s0140-6736(69)91446-9. [DOI] [PubMed] [Google Scholar]
- HARRISON W. H., LEVITT M., UDENFRIEND S. NOREPINEPHRINE SYNTHESIS AND RELEASE IN VIVO MEDIATED BY 3,4-DIHYDROXYPHENETHYLAMINE. J Pharmacol Exp Ther. 1963 Nov;142:157–162. [PubMed] [Google Scholar]
- SHY G. M., DRAGER G. A. A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol. 1960 May;2:511–527. doi: 10.1001/archneur.1960.03840110025004. [DOI] [PubMed] [Google Scholar]
- Yahr M. D., Duvoisin R. C., Hoehn M. M., Schear M. J., Barrett R. E. L-Dopa (L-3,4-dihydroxyphenylanine)--its clinical effects in parkinsonism. Trans Am Neurol Assoc. 1968;93:56–63. [PubMed] [Google Scholar]