Abstract
Practolol (I.C.I. 50172) was used to treat supraventricular dysrhythmias in 32 patients with a rapid ventricular rate and with heart disease of varied aetiology. In 26 patients the average reduction in ventricular rate was 75 per minute, while immediate reversion to sinus rhythm occurred in three patients. The slowing effect was mainly due to a direct action on the atrioventricular node. The effectiveness of practolol was unrelated to the type of dysrhythmia or its aetiology. No serious adverse clinical effects were noted.
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- Brick I., Hutchison K. J., McDevitt D. G., Roddie I. C., Shanks R. G. Comparison of the effects of I.C.I. 50172 and propranolol on the cardiovascular responses to adrenaline, isoprenaline and exercise. Br J Pharmacol. 1968 Sep;34(1):127–140. doi: 10.1111/j.1476-5381.1968.tb07956.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Conway N., Seymour J., Gelson A. Cardiac failure in patients with valvar heart disease after use of propranolol to control atrial fibrillation. Br Med J. 1968 Apr 27;2(5599):213–214. doi: 10.1136/bmj.2.5599.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gibson D. G., Balcon R., Sowton E. Clinical use of I.C.I. 50172 as an antidysrhythmic agent in heart failure. Br Med J. 1968 Jul 20;3(5611):161–163. doi: 10.1136/bmj.3.5611.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jewitt D. E., Mercer C. J., Shillingford J. P. Practolol in the treatment of cardiac dysrhythmias due to acute myocardial infarction. Lancet. 1969 Aug 2;2(7614):227–230. doi: 10.1016/s0140-6736(69)90001-4. [DOI] [PubMed] [Google Scholar]
- STOCK J. P., DALE N. BETA-ADRENERGIC RECEPTOR BLOCKADE IN CARDIAC ARRHYTHMIAS. Br Med J. 1963 Nov 16;2(5367):1230–1233. doi: 10.1136/bmj.2.5367.1230. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shinebourne E., Fleming J., Hamer J. Haemodynamic responses to exercise in hypertension: place of the sympathetic nervous sustem evaluated by a new selective cardiac beta-adrenergic blocking agent ICI 50,172. Cardiovasc Res. 1968 Oct;2(4):379–383. doi: 10.1093/cvr/2.4.379. [DOI] [PubMed] [Google Scholar]
- Sowton E., Balcon R., Cross D., Frick H. Haemodynamic effects of I.C.I. 50172 in patients with ischaemic heart disease. Br Med J. 1968 Jan 27;1(5586):215–216. doi: 10.1136/bmj.1.5586.215. [DOI] [PMC free article] [PubMed] [Google Scholar]