Abstract
In unanaesthetized patients atropine and neostigmine in doses normally used by anaesthetists to reverse muscle relaxants produced a pronounced increase in bowel activity. This response occurred whether atropine was given before or simultaneously with neostigmine.
The response still occurred in 38% of patients anaesthetized without halothane, and possibly this increase in motility might endanger a recently constructed anastomosis. The ileum appeared particularly prone to neostigmine stimulation, and anastomoses involving ileum would seem especially at risk. When halothane was used during anaesthesia the response was completely inhibited during the period studied.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARANY F., JACOBSON B. ENDORADIOSONDE STUDY OF PROPULSION AND PRESSURE ACTIVITY INDUCED BY TEST MEALS, PROSTIGMINE, AND DIPHENOXYLATE IN THE SMALL INTESTINE. Gut. 1964 Feb;5:90–95. doi: 10.1136/gut.5.1.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bell C. M., Lewis C. B. Effect of neostigmine on integrity of ileorectal anastomoses. Br Med J. 1968 Sep 7;3(5618):587–588. doi: 10.1136/bmj.3.5618.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHAUDHARY N. A., TRUELOVE S. C. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. I. Resting patterns of motility. Gastroenterology. 1961 Jan;40:1–17. [PubMed] [Google Scholar]
- DELLER D. J., WANGEL A. G. INTESTINAL MOTILITY IN MAN. I. A STUDY COMBINING THE USE OF INTRALUMINAL PRESSURE RECORDING AND CINERADIOGRAPHY. Gastroenterology. 1965 Jan;48:45–57. [PubMed] [Google Scholar]
- DOUGHTY A. G., WYLIE W. D. Antidotes to true curarizing agents including a report on Ro 2-3198 (Tensilon). Br J Anaesth. 1952 Apr;24(2):66–80. doi: 10.1093/bja/24.2.66. [DOI] [PubMed] [Google Scholar]
- Hannington-Kiff J. G. Timing of atropine and neostigmine in the reversal of muscle relaxants. Br Med J. 1969 Feb 15;1(5641):418–420. doi: 10.1136/bmj.1.5641.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hardcastle J. D., Mann C. V. Study of large bowel peristalsis. Gut. 1968 Oct;9(5):512–520. doi: 10.1136/gut.9.5.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Misiewicz J. J., Connell A. M., Pontes F. A. Comparison of the effect of meals and prostigmine on the proximal and distal colon in patients with and without diarrhoea. Gut. 1966 Oct;7(5):468–473. doi: 10.1136/gut.7.5.468. [DOI] [PMC free article] [PubMed] [Google Scholar]