Abstract
The effect of the aerosol inhalation of 200 μg. of salbutamol and 1,000 μg. of isoprenaline on spirometry and blood-gas tensions was compared in the same 11 asthmatic subjects. Both drugs significantly reduced airway obstruction, and the extent of the reduction did not differ for periods of up to 30 minutes. After isoprenaline tachycardia and a small significant fall in arterial oxygen tension occurred, whereas after salbutamol there was no change in pulse rate and the arterial oxygen tension did not fall.
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Selected References
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- AVIADO D. M., Jr, SCHMIDT C. F. Effects of sympathomimetic drugs on pulmonary circulation: with special reference to a new pulmonary vasodilator. J Pharmacol Exp Ther. 1957 Aug;120(4):512–527. [PubMed] [Google Scholar]
- Choo-Kang Y. F., Simpson W. T., Grant I. W. Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J. 1969 May 3;2(5652):287–289. doi: 10.1136/bmj.2.5652.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Field G. B. The effects of posture, oxygen, isoproterenol and atropine on ventilation-perfusion relationships in the lung in asthma. Clin Sci. 1967 Apr;32(2):279–288. [PubMed] [Google Scholar]
- Kelman G. R., Palmer K. N., Cross M. R. Cardiovascular effects of AH.3365 (salbutamol). Nature. 1969 Mar 29;221(5187):1251–1251. doi: 10.1038/2211251a0. [DOI] [PubMed] [Google Scholar]
- Kennedy M. C., Simpson W. T. Human pharmacological and clinical studies on salbutamol: a specific beta-adrenergic bronchodilator. Br J Dis Chest. 1969 Jul;63(3):165–174. doi: 10.1016/s0007-0971(69)80014-8. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Diament M. L. Dynamic and static lung volumes and blood-gas tensions in bronchial asthma. Lancet. 1969 Mar 22;1(7595):591–593. doi: 10.1016/s0140-6736(69)91531-1. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Diament M. L. Effect of aerosol isoprenaline on blood-gas tensions in severe bronchial asthma. Lancet. 1967 Dec 9;2(7528):1232–1233. doi: 10.1016/s0140-6736(67)90567-3. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Hamilton W. F., Lge J. S., Diament M. L. Effect of a selectivebeta-adrenergic blocker in preventing falls in arterial oxygen tension following isoprenaline in asthmatic subjects. Lancet. 1969 Nov 22;2(7630):1092–1094. doi: 10.1016/s0140-6736(69)90701-6. [DOI] [PubMed] [Google Scholar]