Abstract
Serum creatine kinas (C.K.), aspartate amino-transferase (G.O.T.), and alkaline phosphatase (A.P.) activities were measured in 211 men with serum cholesterol concentrations in the upper one-third of the normal distribution. Of these, 110 were receiving clofibrate and 101 were given identical capsules containing olive oil. These investigations were also carried out on 85 healthy men with low serum cholesterol levels not receiving clofibrate.
No differences were observed in C.K. and G.O.T. activities between any of these groups; A.P. was significantly lower in the clofibrate-treated group. No significant alterations in C.K. occurred during serial observations made in 15 patients with ischaemic heart disease over a period of five months. No instance of myalgia or muscle stiffness was recorded in 452 men who had received clofibrate for one year.
It is concluded that raised C.K. and G.O.T. concentrations and the occurrence of myalgia are uncommon accompaniments of clofibrate treatment.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- KIND P. R., KING E. J. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J Clin Pathol. 1954 Nov;7(4):322–326. doi: 10.1136/jcp.7.4.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KONTTINEN A., PALOHEIMO J. THE EFFECTS OF ATROMID ON SERUM LIPIDS, PROTEINS AND SOME LIVER FUNCTION TESTS IN HYPERCHOLESTEROLAEMIC PATIENTS. J Atheroscler Res. 1963 Sep-Dec;3:525–532. doi: 10.1016/s0368-1319(63)80032-0. [DOI] [PubMed] [Google Scholar]
- Langer T., Levy R. I. Acute muscular syndrome associated with administration of clofibrate. N Engl J Med. 1968 Oct 17;279(16):856–858. doi: 10.1056/NEJM196810172791604. [DOI] [PubMed] [Google Scholar]
- Morgenstern S., Kessler G., Auerbach J., Flor R. V., Klein B. An automated p-nitrophenylphosphate serum alkaline phosphatase procedure for the AutoAnalyzer. Clin Chem. 1965 Sep;11(9):876–888. [PubMed] [Google Scholar]
- OLIVER M. F. Reduction of serum-lipid and uric-acid levels by an orally active androsterone. Lancet. 1962 Jun 23;1(7243):1321–1323. doi: 10.1016/s0140-6736(62)92422-4. [DOI] [PubMed] [Google Scholar]
- Oliver M. F. The primary preventiono of ischemic heart disease by means of Atromid-S (clofibrate). Bull N Y Acad Med. 1968 Aug;44(8):1021–1027. [PMC free article] [PubMed] [Google Scholar]
- REITMAN S., FRANKEL S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957 Jul;28(1):56–63. doi: 10.1093/ajcp/28.1.56. [DOI] [PubMed] [Google Scholar]