Abstract
Radioactive 125I-labelled human fibrinogen was given to 11 recipients of cadaveric renal transplants and the radioactivity of the transplant was measured with a scintillation counter. In the six patients with no increase in radioactivity over the transplants there was no evidence of rejection. The five patients with an increased transplant radioactivity all had other evidence of rejection at that time. In one patient the test detected rejection in the absence of any other signs, and this result was afterwards confirmed by renal biopsy. The test in one patient was invalidated by haemorrhage occurring from the site of a renal biopsy, and other possible errors in the test may arise.
It is suggested that the technique may have particular value in recipients with delayed function of their transplants, but may also be useful in patients with functioning transplants in helping to confirm the diagnosis of rejection suspected on other grounds.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Antoine B., Neveu T., Ward P. D. Fibrinuria during renal transplantation. Transplantation. 1969 Aug;8(2):98–109. doi: 10.1097/00007890-196908000-00002. [DOI] [PubMed] [Google Scholar]
- Braun W. E., Merrill J. P. Urine fibrinogen fragments in human renal allografts. A possible mechanism of renal injury. N Engl J Med. 1968 Jun 20;278(25):1366–1371. doi: 10.1056/NEJM196806202782503. [DOI] [PubMed] [Google Scholar]
- Busch G. J., Braun W. E., Carpenter C. B., Corson J. M., Galvanek E. R., Reynolds E. S., Merrill J. P., Dammin G. J. Intravascular coagulation (IVC) in human renal allograft rejection. Transplant Proc. 1969 Mar;1(1):267–270. [PubMed] [Google Scholar]
- Colman R. W., Braun W. E., Busch G. J., Dammin G. J., Merrill J. P. Coagulation studies in the hyperacute and other forms of renal-allograft rejection. N Engl J Med. 1969 Sep 25;281(13):685–691. doi: 10.1056/NEJM196909252811301. [DOI] [PubMed] [Google Scholar]
- Flanc C., Kakkar V. V., Clarke M. B. The detection of venous thrombosis of the legs using 125-I-labelled fibrinogen. Br J Surg. 1968 Oct;55(10):742–747. doi: 10.1002/bjs.1800551007. [DOI] [PubMed] [Google Scholar]
- Lindquist R. R., Guttmann R. D., Merrill J. P. Renal transplantation in the inbred rat. II. An immunohistochemical study of acute allograft rejection. Am J Pathol. 1968 Mar;52(3):531–545. [PMC free article] [PubMed] [Google Scholar]
- McFarlane A. S. Catabolism of iodine-labelled fibrinogen. Proc R Soc Med. 1969 Nov;62(11 Pt 1):1127–1129. doi: 10.1177/003591576906211P125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKenzie I. F., Whittingham S. Deposits of immunoglobulin and fibrin in human allografted kidneys. Lancet. 1968 Dec 21;2(7582):1313–1316. doi: 10.1016/s0140-6736(68)91815-1. [DOI] [PubMed] [Google Scholar]
- Myburgh J. A., Cohen I., Gecelter L., Meyers A. M., Abrahams C., Furman K. I., Goldberg B., van Blerk P. J. Hyperacute rejection in human-kidney allografts-shwartzman or arthus reaction? N Engl J Med. 1969 Jul 17;281(3):131–135. doi: 10.1056/NEJM196907172810305. [DOI] [PubMed] [Google Scholar]
- Negus D., Pinto D. J., Le Quesne L. P., Brown N., Chapman M. 125-I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography. Br J Surg. 1968 Nov;55(11):835–839. [PubMed] [Google Scholar]
- VON KAULLA K. N., SCHULTZ R. L. Methods for the evaluation of human fibrinolysis; studies with two combined technics. Am J Clin Pathol. 1958 Feb;29(2):104–112. doi: 10.1093/ajcp/29.2.104. [DOI] [PubMed] [Google Scholar]