Abstract
A patient with reactive hypoglycaemia showed hypersecretion of insulin in response to enteral beta-cell stimulation. Increased levels of gut glucagon-like immunoreactivity in serum were demonstrated by use of specific antisera. Other measurable hormones influencing carbohydrate metabolism were within normal limits. It is suggested that gut glucagon-like immunoreactivity may be of pathogenetic significance in reactive hypoglycaemia.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CONN J. W., SELTZER H. S. Spontaneous hypoglycemia. Am J Med. 1955 Sep;19(3):460–478. doi: 10.1016/0002-9343(55)90130-3. [DOI] [PubMed] [Google Scholar]
- Chisholm D. J., Young J. D., Lazarus L. The gastrointestinal stimulus to insulin release. I. Secretin. J Clin Invest. 1969 Aug;48(8):1453–1460. doi: 10.1172/JCI106111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dupre J., Curtis J. D., Unger R. H., Waddell R. W., Beck J. C. Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man. J Clin Invest. 1969 Apr;48(4):745–757. doi: 10.1172/JCI106032. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holdsworth C. D., Turner D., McIntyre N. Pathophysiology of post-gastrectomy hypoglycaemia. Br Med J. 1969 Nov 1;4(5678):257–259. doi: 10.1136/bmj.4.5678.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McIntyre N., Holdsworth C. D., Turner D. S. Intestinal factors in the control of insulin secretion. J Clin Endocrinol Metab. 1965 Oct;25(10):1317–1324. doi: 10.1210/jcem-25-10-1317. [DOI] [PubMed] [Google Scholar]
- Sussman K. E., Stimmler L., Birenboim H. Plasma insulin levels during reactive hypoglycemia. Diabetes. 1966 Jan;15(1):1–4. doi: 10.2337/diab.15.1.1. [DOI] [PubMed] [Google Scholar]
- Unger R. H. New ideas concerning the physiologic roles of glucagon. Am J Med Sci. 1968 May;255:273–276. doi: 10.1097/00000441-196805000-00001. [DOI] [PubMed] [Google Scholar]
- Unger R. H., Ohneda A., Valverde I., Eisentraut A. M., Exton J. Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose. J Clin Invest. 1968 Jan;47(1):48–65. doi: 10.1172/JCI105714. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yde H. A simplified technique for the determination of growth hormone dependent sulfation factor, using intact animals. Acta Endocrinol (Copenh) 1968 Apr;57(4):557–564. doi: 10.1530/acta.0.0570557. [DOI] [PubMed] [Google Scholar]