Abstract
Serum levels of creatine phosphokinase (CPK) were estimated in pigs. Among those known to react abnormally either to halothane alone or to halothane and suxamethonium most had very high levels of CPK. Twenty-four hours after five minutes' anaesthesia with halothane and oxygen a sustained, pronounced rise in the serum CPK occurred in some pigs—principally but not exclusively in the abnormal reactors. Estimation of the serum level of CPK may be a useful screening test for an abnormal hyperpyrexial response to halothane.
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Selected References
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- Denborough M. A., Ebeling P., King J. O., Zapf P. Myopathy and malignant hyperpyrexia. Lancet. 1970 May 30;1(7657):1138–1140. doi: 10.1016/s0140-6736(70)91215-8. [DOI] [PubMed] [Google Scholar]
- Hall L. W., Woolf N., Bradley J. W., Jolly D. W. Unusual reaction to suxamethonium chloride. Br Med J. 1966 Nov 26;2(5525):1305–1305. doi: 10.1136/bmj.2.5525.1305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harrison G. G., Saunders S. J., Biebuyck J. F., Hickman R., Dent D. M., Weaver V., Terblanche J. Anaesthetic-induced malignant hyperpyrexia and a method for its prediction. Br J Anaesth. 1969 Oct;41(10):844–855. doi: 10.1093/bja/41.10.844. [DOI] [PubMed] [Google Scholar]
- Isaacs H., Barlow M. B. Malignant hyperpyrexia during anaesthesia: possible association with subclinical myopathy. Br Med J. 1970 Jan 31;1(5691):275–277. doi: 10.1136/bmj.1.5691.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILSON K. M., EVANS K. A., CARTER C. O. CREATINE KINASE LEVELS IN WOMEN WHO CARRY GENES FOR THREE TYPES OF MUSCULAR DYSTROPHY. Br Med J. 1965 Mar 20;1(5437):750–753. doi: 10.1136/bmj.1.5437.750. [DOI] [PMC free article] [PubMed] [Google Scholar]