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. 1970 Aug 22;3(5720):438–439. doi: 10.1136/bmj.3.5720.438

Thromboembolic Complications in Myelomatosis

D Catovsky, N B Ikoku, W R Pitney, D A G Galton
PMCID: PMC1701392  PMID: 5454323

Abstract

Fourteen cases of myelomatosis associated with major thromboembolic complications are reported. Six patients died of pulmonary embolism, seven had deep-vein thrombosis as a presenting symptom, and three had evidence of amyloidosis. A preliminary estimate of the incidence of thromboembolism based on 376 patients admitted so far to the Medical Research Council's myelomatosis trial is about 3%, while pulmonary embolism accounted for about 3% of all deaths. Possibly a hypercoagulable state and the presence of amyloidosis may be important in the pathogenesis of this complication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMUNDSEN M. A., SPITTELL J. A., Jr, THOMPSON J. H., Jr, OWEN C. A., Jr Hypercoagulability associated with malignant disease and with the postoperative state. Evidence for elevated levels of antihemophilic globulin. Ann Intern Med. 1963 Apr;58:608–616. doi: 10.7326/0003-4819-58-4-608. [DOI] [PubMed] [Google Scholar]
  2. BARCLAY G. P., CAMERON H. M., LOUGHRIDGE L. W. Amyloid disease of the kidney and renal vein thrombosis. Q J Med. 1960 Jan;29:137–151. [PubMed] [Google Scholar]
  3. Barth W. F., Willerson J. T., Waldmann T. A., Decker J. L. Primary amyloidosis. Clinical, immunochemical and immunoglobulin metabolism. Studies in fifteen patients. Am J Med. 1969 Aug;47(2):259–273. doi: 10.1016/0002-9343(69)90152-1. [DOI] [PubMed] [Google Scholar]
  4. Bowie E. J., Maldonado E., Brown A. L., Didisheim P., Owen C. A., Jr Intravascular coagulation in systemic amyloidosis. Thromb Diath Haemorrh Suppl. 1969;36:305–312. [PubMed] [Google Scholar]
  5. Davis R. B., Theologides A., Kennedy B. J. Comparative studies of blood coagulation and platelet aggregation in patients with cancer and nonmalignant diseases. Ann Intern Med. 1969 Jul;71(1):67–80. doi: 10.7326/0003-4819-71-1-67. [DOI] [PubMed] [Google Scholar]
  6. HARRISON C. V., MILNE M. D., STEINER R. E. Clinical aspects of renal vein thrombosis. Q J Med. 1956 Jul;25(99):285–298. [PubMed] [Google Scholar]
  7. LAFLER C. J., HINERMAN D. L. A morphologic study of pancreatic carcinoma with reference to multiple thrombi. Cancer. 1961 Sep-Oct;14:944–952. doi: 10.1002/1097-0142(196109/10)14:5<944::aid-cncr2820140506>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  8. LIEBERMAN J. S., BORRERO J., URDANETA E., WRIGHT I. S. Thrombophlebitis and cancer. JAMA. 1961 Aug 26;177:542–545. doi: 10.1001/jama.1961.03040340006002. [DOI] [PubMed] [Google Scholar]
  9. Miller S. P., Sanchez-Avalos J., Stefanski T., Zuckerman L. Coagulation disorders in cancer. I. Clinical and laboratory studies. Cancer. 1967 Sep;20(9):1452–1465. doi: 10.1002/1097-0142(196709)20:9<1452::aid-cncr2820200912>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  10. Niléhn J. E., Nilsson I. M. Coagulation studies in different types of myeloma. Acta Med Scand Suppl. 1966;445:194–199. doi: 10.1111/j.0954-6820.1966.tb02360.x. [DOI] [PubMed] [Google Scholar]
  11. PITNEY W. R., ELLIOTT M. H. Plasma antihaemophilic-factor concentrations in the Australian aborigine and in conditions associated with hyperglobulinaemia. Nature. 1960 Feb 6;185:397–397. doi: 10.1038/185397a0. [DOI] [PubMed] [Google Scholar]
  12. Propp S., Dylong V. M. High antihaemophilic factor in multiple myeloma. Nature. 1965 Jul 10;207(993):206–206. doi: 10.1038/207206a0. [DOI] [PubMed] [Google Scholar]
  13. Regoeczi E. Occlusion of plasma proteins by human fibrin: studies using trace-labelled proteins. Br J Haematol. 1968 Mar;14(3):279–290. doi: 10.1111/j.1365-2141.1968.tb01498.x. [DOI] [PubMed] [Google Scholar]
  14. Sanchez-Avalos J., Soong B. C., Miller S. P. Coagulation disorders in cancer. II. Multiple myeloma. Cancer. 1969 Jun;23(6):1388–1398. doi: 10.1002/1097-0142(196906)23:6<1388::aid-cncr2820230621>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  15. Talerman A. Clinico-pathological study of multiple myeloma in Jamaica. Br J Cancer. 1969 Jun;23(2):285–293. doi: 10.1038/bjc.1969.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. VIALA J. J., THOUVEREZ J. P., BELLEVILLE J., REVOL L., CROIZAT P. ETUDE DE LA COAGULATION DU SANG AU COURS DES DYSGLOBULIN'EMIES MY'ELOMES ET MALADIE DE WALDENSTROM 'A PROPOS DE 48 OBSERVATIONS. Hemostase. 1963 Oct-Dec;3:303–323. [PubMed] [Google Scholar]
  17. Wiernik P. H., Serpick A. A. Pulmonary embolus in acute myelocytic leukemia. Cancer. 1969 Sep;24(3):581–584. doi: 10.1002/1097-0142(196909)24:3<581::aid-cncr2820240324>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]

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