Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1970 Aug 22;3(5720):427–428. doi: 10.1136/bmj.3.5720.427

Measurement of Plasma Digoxin Concentration by Radioimmunoassay

D C Evered, C Chapman, C J Hayter
PMCID: PMC1701412  PMID: 5454320

Abstract

A rapid, sensitive, and precise method for measuring the plasma digoxin concentration has been developed with the radioimmunoassay technique. Seventy patients receiving digoxin were shown to have plasma digoxin concentrations between 0·4 and 5 ng./ml. Preliminary studies show that though there is a positive correlation between total daily dose and the plasma digoxin concentration, the relationship is not close, and a relatively wide range of plasma digoxin concentrations appear to be consistent with effective digitalization.

Full text

PDF
427

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Binnion P. F., Morgan L. M., Stevenson H. M., Fletcher E. Plasma and myocardial digoxin concentrations in patients on oral therapy. Br Heart J. 1969 Sep;31(5):636–640. doi: 10.1136/hrt.31.5.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Doherty J. E., Perkins W. H., Flanigan W. J. The distribution and concentration of tritiated digoxin in human tissues. Ann Intern Med. 1967 Jan;66(1):116–124. doi: 10.7326/0003-4819-66-1-116. [DOI] [PubMed] [Google Scholar]
  3. Evered D. C. A simple liquid scintillator solution for assay of tritium in plasma or serum. Int J Appl Radiat Isot. 1969 Aug;20(8):608–611. doi: 10.1016/0020-708x(69)90087-8. [DOI] [PubMed] [Google Scholar]
  4. Grahame-Smith D. G. Everest MS: Measurement of digoxin in plasma and its use in diagnosis of digoxin intoxication. Br Med J. 1969 Feb 1;1(5639):286–289. doi: 10.1136/bmj.1.5639.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Herbert V., Lau K. S., Gottlieb C. W., Bleicher S. J. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab. 1965 Oct;25(10):1375–1384. doi: 10.1210/jcem-25-10-1375. [DOI] [PubMed] [Google Scholar]
  6. LOWENSTEIN J. M. A METHOD FOR MEASURING PLASMA LEVELS OF DIGITALIS GLYCOSIDES. Circulation. 1965 Feb;31:228–233. doi: 10.1161/01.cir.31.2.228. [DOI] [PubMed] [Google Scholar]
  7. Lowenstein J. M., Corrill E. M. An improved method for measuring plasma and tissue concentrations of digitalis glycosides. J Lab Clin Med. 1966 Jun;67(6):1048–1052. [PubMed] [Google Scholar]
  8. Lukas D. A., Peterson R. E. Double isotope dilution derivative assay of digitoxin in plasma, urine, and stool of patients maintained on the drug. J Clin Invest. 1966 May;45(5):782–795. doi: 10.1172/JCI105393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Marcus F. I., Burkhalter L., Cuccia C., Pavlovich J., Kapadia G. G. Administration of tritiated digoxin with and without a loading dose. A metabolic study. Circulation. 1966 Nov;34(5):865–874. doi: 10.1161/01.cir.34.5.865. [DOI] [PubMed] [Google Scholar]
  10. Oliver G. C., Jr, Parker B. M., Brasfield D. L., Parker C. W. The measurement of digitoxin in human serum by radioimmunoassay. J Clin Invest. 1968 May;47(5):1035–1042. doi: 10.1172/JCI105793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Smith T. W., Butler V. P., Jr, Haber E. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. N Engl J Med. 1969 Nov 27;281(22):1212–1216. doi: 10.1056/NEJM196911272812203. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES