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. 1970 Sep 5;3(5722):559-560, 561. doi: 10.1136/bmj.3.5722.559

Papillary Necrosis in Rats Caused by Aspirin and Aspirin-containing Mixtures

Ranjit S Nanra, Priscilla Kincaid-Smith
PMCID: PMC1701568  PMID: 5454357

Abstract

Nearly half the rats gavage-fed with aspirin and aspirin-containing mixtures developed papillary necrosis in 20 weeks. This incidence is similar to that found in rats on A.P.C. mixtures with high and low concentrations of p-chloracetanilide, an impurity of phenacetin. Aspirin alone produced necrosis in 7 out of 19 rats (36·8%) whereas phenacetin in the same dose had failed to cause any renal damage over six to nine months. If these results also apply to man they suggest that aspirin and not phenacetin may be the major factor in analgesic nephropathy in patients taking A.P.C. mixtures. An augmented clearance of aspirin appeared to afford some protection to the medulla, and it is suggested that this observation may have important clinical and epidemiological applications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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