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. 1970 Sep 5;3(5722):545–547. doi: 10.1136/bmj.3.5722.545

Fibrin Degradation Products in Pre-eclamptic Toxaemia and Eclampsia

A H Henderson, D J Pugsley, D P Thomas
PMCID: PMC1701571  PMID: 5454355

Abstract

Serum levels of fibrinogen/fibrin degradation products, measured in African women, were significantly higher in pre-eclamptic toxaemia than in normal pregnancy, and were significantly higher with eclampsia than with toxaemia. These findings are in accord with the hypothesis that eclampsia and toxaemia are associated with disseminated intravascular coagulation, which may be responsible for certain clinical manifestations of these conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASTRUP T. The biological significance of fibrinolysis. Lancet. 1956 Sep 15;271(6942):565–568. doi: 10.1016/s0140-6736(56)92048-7. [DOI] [PubMed] [Google Scholar]
  2. BIEZENSKI J. J., MOORE H. C. Fibrinolysis in normal pregnancy. J Clin Pathol. 1958 Jul;11(4):306–310. doi: 10.1136/jcp.11.4.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BRAIN M. C., DACIE J. V., HOURIHANE D. O. Microangiopathic haemolytic anaemia: the possible role of vascular lesions in pathogenesis. Br J Haematol. 1962 Oct;8:358–374. doi: 10.1111/j.1365-2141.1962.tb06541.x. [DOI] [PubMed] [Google Scholar]
  4. Bonnar J., Davidson J. F., Pidgeon C. F., McNicol G. P., Douglas A. S. Fibrin degradation products in normal and abnormal pregnancy and parturition. Br Med J. 1969 Jul 19;3(5663):137–140. doi: 10.1136/bmj.3.5663.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bonnar J., McNicol G. P., Douglas A. S. Fibrinolytic enzyme system and pregnancy. Br Med J. 1969 Aug 16;3(5667):387–389. doi: 10.1136/bmj.3.5667.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brain M. C., Kuah K. B., Dixon H. G. Heparin treatment of haemolysis and thrombocytopenia in pre-eclampsia. Report of a case and a review of the literature. J Obstet Gynaecol Br Commonw. 1967 Oct;74(5):702–711. doi: 10.1111/j.1471-0528.1967.tb03784.x. [DOI] [PubMed] [Google Scholar]
  7. GOVAN A. D. The pathogenesis of eclamptic lesions. Pathol Microbiol (Basel) 1961;24:561–575. doi: 10.1159/000161165. [DOI] [PubMed] [Google Scholar]
  8. Hawiger J., Niewiarowski S., Gurewich V., Thomas D. P. Measurement of fibrinogen and fibrin degradation products in serum by staphylococcal clumping test. J Lab Clin Med. 1970 Jan;75(1):93–108. [PubMed] [Google Scholar]
  9. MORRIS R. H., VASSALLI P., BELLER F. K., MCCLUSKEY R. T. IMMUNOFLUORESCENT STUDIES OF RENAL BIOPSIES IN THE DIAGNOSIS OF TOXEMIA OF PREGNANCY. Obstet Gynecol. 1964 Jul;24:32–46. [PubMed] [Google Scholar]
  10. McKAY D. G., MERRILL S. J., WEINER A. E., HERTIG A. T., REID D. E. The pathologic anatomy of eclampsia, bilateral renal cortical necrosis, pituitary necrosis, and other acute fatal complications of pregnancy, and its possible relationship to the generalized Shwartzman phenomenon. Am J Obstet Gynecol. 1953 Sep;66(3):507–539. doi: 10.1016/0002-9378(53)90068-4. [DOI] [PubMed] [Google Scholar]
  11. McKAY D. G., SHAPIRO S. S. Alterations in the blood coagulation system induced by bacterial endotoxin. I. In vivo (generalized Shwartzman reaction). J Exp Med. 1958 Mar 1;107(3):353–367. doi: 10.1084/jem.107.3.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Merskey C., Kleiner G. J., Johnson A. J. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966 Jul;28(1):1–18. [PubMed] [Google Scholar]
  13. Nilsson I. M., Kullander S. Coagulation and fibrinolytic studies during pregnancy. Acta Obstet Gynecol Scand. 1967;46(3):273–285. doi: 10.3109/00016346709158632. [DOI] [PubMed] [Google Scholar]
  14. PECHET L., ALEXANDER B. Increased clotting factors in pregnacy. N Engl J Med. 1961 Nov 30;265:1093–1097. doi: 10.1056/NEJM196111302652205. [DOI] [PubMed] [Google Scholar]
  15. TALBERT L. M., LANGDELL R. D. NORMAL VALUES OF CERTAIN FACTORS IN THE BLOOD CLOTTING MECHANISM IN PREGNANCY. Am J Obstet Gynecol. 1964 Sep 1;90:44–50. doi: 10.1016/s0002-9378(16)34890-6. [DOI] [PubMed] [Google Scholar]
  16. TAUB R. N., RODRIGUEZ-ERDMANN F., DAMESHEK W. INTRAVASCULAR COAGULATION, THE SHWARTZMAN REACTION AND THE PATHOGENESIS OF T.T.P. Blood. 1964 Dec;24:775–779. [PubMed] [Google Scholar]
  17. VASSALLI P., MORRIS R. H., MCCLUSKEY R. T. THE PATHOGENIC ROLE OF FIBRIN DEPOSITION IN THE GLOMERULAR LESIONS OF TOXEMIA OF PREGNANCY. J Exp Med. 1963 Sep 1;118:467–478. doi: 10.1084/jem.118.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wardle E. N., Menon I. S. Fibrinolysis in pre-eclamptic toxaemia of pregnancy. Br Med J. 1969 Jun 7;2(5657):625–627. doi: 10.1136/bmj.2.5657.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Woodfield D. G., Cole S. K., Allan A. G., Cash J. D. Serum fibrin degradation products throughout normal pregnancy. Br Med J. 1968 Dec 14;4(5632):665–668. doi: 10.1136/bmj.4.5632.665. [DOI] [PMC free article] [PubMed] [Google Scholar]

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